2018
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model
Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model. Journal Of Vascular Surgery 2018, 68: 188s-200s.e4. PMID: 30064835, PMCID: PMC6252159, DOI: 10.1016/j.jvs.2018.05.206.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsBlood Vessel Prosthesis ImplantationCarotid Artery, CommonCell ProliferationChemotaxis, LeukocyteDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersFemaleGelsGraft Occlusion, VascularHyperplasiaJugular VeinsNeointimaPoloxamerPolylactic Acid-Polyglycolic Acid CopolymerRabbitsTime FactorsConceptsRabbit vein graft modelLocal perivascular deliveryVein graftsPerivascular deliveryVein graft modelNeointimal hyperplasiaResolvin D1Macrophage infiltrationLipid mediatorsSpecialized proresolving lipid mediatorsGraft modelTotal leukocyte infiltrationMajor wound complicationsProresolving lipid mediatorsVein bypass graftsD-series resolvinsNew Zealand white rabbitsPotential therapeutic roleIpsilateral jugular veinCell proliferationZealand white rabbitsExcessive neointimal hyperplasiaVein graft hyperplasiaPerivascular fashionRvD1 treatment
2016
Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device
Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS. Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device. Journal Of Biomedical Materials Research Part A 2016, 105: 31-41. PMID: 27508346, PMCID: PMC5124518, DOI: 10.1002/jbm.a.35861.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAnimalsDocosahexaenoic AcidsDrug ImplantsHumansLactic AcidMaleMembranes, ArtificialMuscle, Smooth, VascularMyocytes, Smooth MusclePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRabbitsRatsRats, Sprague-DawleyConceptsResolvin D1Rat carotid artery modelProresolving lipid mediatorsHuman vascular endothelialNF-κB activationSmooth muscle cellsCarotid artery modelTissue injuryEvidence of cytotoxicityRvD1Lipid mediatorsRabbit aortaVSMC migrationMuscle cellsFlow chamber systemBlood vesselsLocal deliveryVascular endothelialArtery modelRelevant levelsVivoTissueD1Vascular tissueDaysPerivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury
Wu B, Mottola G, Chatterjee A, Lance KD, Chen M, Siguenza IO, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury. Journal Of Vascular Surgery 2016, 65: 207-217.e3. PMID: 27034112, PMCID: PMC5040608, DOI: 10.1016/j.jvs.2016.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsAortaCardiovascular AgentsCarotid Artery DiseasesCell MovementCell ProliferationCells, CulturedCytoskeletonDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersDrug CompoundingHyperplasiaInflammation MediatorsKi-67 AntigenLactic AcidMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaOxidative StressPoloxamerPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRats, Sprague-DawleyTime FactorsTranscription Factor RelAConceptsLocal perivascular deliveryPerivascular deliveryRat modelCarotid angioplastyNeointimal hyperplasiaResolvin D1Inflammatory pathwaysNeointimal formationArterial smooth muscle cell proliferationNuclear factor-κB activationEffects of RvD1Smooth muscle cell proliferationKi67 proliferation indexResolution of inflammationNegative vessel remodelingMuscle cell proliferationSmooth muscle cellsMuscle cell responseWrap groupArterial injuryRat aortaEvidence of cytotoxicityRvD1Lipid mediatorsProliferation index