2017
Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications
Wu B, Mottola G, Schaller M, Upchurch GR, Conte MS. Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications. Molecular Aspects Of Medicine 2017, 58: 72-82. PMID: 28765077, PMCID: PMC5660644, DOI: 10.1016/j.mam.2017.07.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecialized pro-resolving lipid mediatorsVascular injuryLipid mediatorsVSMC migrationPro-resolving lipid mediatorsVascular smooth muscle cell activationSmooth muscle cell activationSpecialized lipid mediatorsAcute vascular injuryElaboration of cytokinesDisease-related eventsEndothelial cell disruptionMuscle cell activationImportant clinical contextsClearance of debrisMatrix protein depositionLeukocyte effluxBypass GraftingBypass surgeryBalloon angioplastyLeukocyte recruitmentAneurysm formationInflammatory signalsExperimental aneurysm formationLumen compromise
2016
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury
Wu B, Mottola G, Chatterjee A, Lance KD, Chen M, Siguenza IO, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury. Journal Of Vascular Surgery 2016, 65: 207-217.e3. PMID: 27034112, PMCID: PMC5040608, DOI: 10.1016/j.jvs.2016.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsAortaCardiovascular AgentsCarotid Artery DiseasesCell MovementCell ProliferationCells, CulturedCytoskeletonDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersDrug CompoundingHyperplasiaInflammation MediatorsKi-67 AntigenLactic AcidMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaOxidative StressPoloxamerPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRats, Sprague-DawleyTime FactorsTranscription Factor RelAConceptsLocal perivascular deliveryPerivascular deliveryRat modelCarotid angioplastyNeointimal hyperplasiaResolvin D1Inflammatory pathwaysNeointimal formationArterial smooth muscle cell proliferationNuclear factor-κB activationEffects of RvD1Smooth muscle cell proliferationKi67 proliferation indexResolution of inflammationNegative vessel remodelingMuscle cell proliferationSmooth muscle cellsMuscle cell responseWrap groupArterial injuryRat aortaEvidence of cytotoxicityRvD1Lipid mediatorsProliferation index
2013
D‐series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury
Miyahara T, Runge S, Chatterjee A, Chen M, Mottola G, Fitzgerald JM, Serhan CN, Conte MS. D‐series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. The FASEB Journal 2013, 27: 2220-2232. PMID: 23407709, PMCID: PMC3659350, DOI: 10.1096/fj.12-225615.Peer-Reviewed Original ResearchConceptsD-series resolvinsVascular injuryLipid mediatorsNeointimal hyperplasiaBalloon-injured rabbit arteriesMonocyte adhesionVascular smooth muscle cell activationSuperoxide productionSmooth muscle cell activationSpecialized lipid mediatorsExpression of receptorsProinflammatory gene expressionDose-dependent inhibitionMuscle cell activationVascular smooth muscle cell phenotypeSmooth muscle cell phenotypeMuscle cell phenotypeArterial angioplastyLeukocyte recruitmentHuman VSMCsVSMC proliferationGene expression assaysRabbit arteriesVascular homeostasisRvD2