Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway
Mottola G, Chatterjee A, Wu B, Chen M, Conte MS. Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. PLOS ONE 2017, 12: e0174936. PMID: 28362840, PMCID: PMC5376330, DOI: 10.1371/journal.pone.0174936.Peer-Reviewed Original ResearchConceptsAT-RvD1Vascular smooth muscle cell migrationALX/FPR2Smooth muscle cell migrationVSMC migrationMuscle cell migrationRp-8-BrResolvin D1Specialized pro-resolving lipid mediatorsAspirin-triggered resolvin D1Pro-resolving lipid mediatorsCyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathwayCAMP levelsHuman saphenous veinPlatelet-derived growth factorTreatment of VSMCCell migrationPKA activityIntracellular cAMP levelsCAMP/PKA pathwaySaphenous veinRac1 activityRvD1 receptorIntimal hyperplasiaLipid mediators