2018
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model
Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model. Journal Of Vascular Surgery 2018, 68: 188s-200s.e4. PMID: 30064835, PMCID: PMC6252159, DOI: 10.1016/j.jvs.2018.05.206.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsBlood Vessel Prosthesis ImplantationCarotid Artery, CommonCell ProliferationChemotaxis, LeukocyteDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersFemaleGelsGraft Occlusion, VascularHyperplasiaJugular VeinsNeointimaPoloxamerPolylactic Acid-Polyglycolic Acid CopolymerRabbitsTime FactorsConceptsRabbit vein graft modelLocal perivascular deliveryVein graftsPerivascular deliveryVein graft modelNeointimal hyperplasiaResolvin D1Macrophage infiltrationLipid mediatorsSpecialized proresolving lipid mediatorsGraft modelTotal leukocyte infiltrationMajor wound complicationsProresolving lipid mediatorsVein bypass graftsD-series resolvinsNew Zealand white rabbitsPotential therapeutic roleIpsilateral jugular veinCell proliferationZealand white rabbitsExcessive neointimal hyperplasiaVein graft hyperplasiaPerivascular fashionRvD1 treatment
2017
Biosynthesis of proresolving lipid mediators by vascular cells and tissues
Chatterjee A, Komshian S, Sansbury BE, Wu B, Mottola G, Chen M, Spite M, Conte MS. Biosynthesis of proresolving lipid mediators by vascular cells and tissues. The FASEB Journal 2017, 31: 3393-3402. PMID: 28442547, PMCID: PMC6207217, DOI: 10.1096/fj.201700082r.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesArachidonate 5-LipoxygenaseCells, CulturedCytokinesDocosahexaenoic AcidsEndothelial CellsGene Expression RegulationHumansInflammationLeukocytesLipid MetabolismMolecular StructureMyocytes, Smooth MuscleProtein TransportReceptors, Formyl PeptideReceptors, G-Protein-CoupledReceptors, LipoxinConceptsVascular smooth muscle cellsD-series resolvinsLipid mediatorsDocosahexaenoic acidVascular cellsEndothelial cellsRvD1 receptor ALX/FPR2Receptor ALX/FPR2Proresolving lipid mediatorsALX/FPR2Vascular injury responseHuman arteriesSmooth muscle cellsHuman saphenous vein endothelial cellsSaphenous vein endothelial cellsIntact human arteriesVein endothelial cellsResolvin D1Vascular healthNovel homeostatic mechanismCellular sourceInjury responseMonocyte adhesionMuscle cellsLiquid chromatography-tandem mass spectrometry
2016
Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device
Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS. Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device. Journal Of Biomedical Materials Research Part A 2016, 105: 31-41. PMID: 27508346, PMCID: PMC5124518, DOI: 10.1002/jbm.a.35861.Peer-Reviewed Original ResearchConceptsResolvin D1Rat carotid artery modelProresolving lipid mediatorsHuman vascular endothelialNF-κB activationSmooth muscle cellsCarotid artery modelTissue injuryEvidence of cytotoxicityRvD1Lipid mediatorsRabbit aortaVSMC migrationMuscle cellsFlow chamber systemBlood vesselsLocal deliveryVascular endothelialArtery modelRelevant levelsVivoTissueD1Vascular tissueDays