The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells
Chatterjee A, Sharma A, Chen M, Toy R, Mottola G, Conte MS. The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells. PLOS ONE 2014, 9: e113480. PMID: 25409514, PMCID: PMC4237455, DOI: 10.1371/journal.pone.0113480.Peer-Reviewed Original ResearchMeSH KeywordsCell AdhesionCells, CulturedCyclic AMPDocosahexaenoic AcidsDown-RegulationEndothelial CellsE-SelectinHumansMuscle, Smooth, VascularNADPH OxidasesNF-kappa BOxidative StressPhosphorylationReactive Oxygen SpeciesSignal TransductionTranscription Factor RelATumor Necrosis Factor-alphaU937 CellsUp-RegulationConceptsInflammatory signaling pathwaysBroad anti-inflammatory actionsMonocyte adhesionCyclic AMPTumor necrosis factor alphaAdhesion molecules E-selectinPro-resolving responseNF-κB p65 subunitPro-inflammatory mediatorsAnti-inflammatory actionPro-inflammatory signalsVascular smooth muscleNecrosis factor alphaAttenuation of TNFHuman saphenous vein ECsHuman vascular endothelialBioactive lipid mediatorsNF-κB activationSmooth muscle cellsTNF-α effectSignaling pathwaysBronchial epithelial cellsIntracellular cyclic AMPTime-dependent increaseVascular inflammation