2017
Biosynthesis of proresolving lipid mediators by vascular cells and tissues
Chatterjee A, Komshian S, Sansbury BE, Wu B, Mottola G, Chen M, Spite M, Conte MS. Biosynthesis of proresolving lipid mediators by vascular cells and tissues. The FASEB Journal 2017, 31: 3393-3402. PMID: 28442547, PMCID: PMC6207217, DOI: 10.1096/fj.201700082r.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesArachidonate 5-LipoxygenaseCells, CulturedCytokinesDocosahexaenoic AcidsEndothelial CellsGene Expression RegulationHumansInflammationLeukocytesLipid MetabolismMolecular StructureMyocytes, Smooth MuscleProtein TransportReceptors, Formyl PeptideReceptors, G-Protein-CoupledReceptors, LipoxinConceptsVascular smooth muscle cellsD-series resolvinsLipid mediatorsDocosahexaenoic acidVascular cellsEndothelial cellsRvD1 receptor ALX/FPR2Receptor ALX/FPR2Proresolving lipid mediatorsALX/FPR2Vascular injury responseHuman arteriesSmooth muscle cellsHuman saphenous vein endothelial cellsSaphenous vein endothelial cellsIntact human arteriesVein endothelial cellsResolvin D1Vascular healthNovel homeostatic mechanismCellular sourceInjury responseMonocyte adhesionMuscle cellsLiquid chromatography-tandem mass spectrometry
2014
The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells
Chatterjee A, Sharma A, Chen M, Toy R, Mottola G, Conte MS. The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells. PLOS ONE 2014, 9: e113480. PMID: 25409514, PMCID: PMC4237455, DOI: 10.1371/journal.pone.0113480.Peer-Reviewed Original ResearchMeSH KeywordsCell AdhesionCells, CulturedCyclic AMPDocosahexaenoic AcidsDown-RegulationEndothelial CellsE-SelectinHumansMuscle, Smooth, VascularNADPH OxidasesNF-kappa BOxidative StressPhosphorylationReactive Oxygen SpeciesSignal TransductionTranscription Factor RelATumor Necrosis Factor-alphaU937 CellsUp-RegulationConceptsInflammatory signaling pathwaysBroad anti-inflammatory actionsMonocyte adhesionCyclic AMPTumor necrosis factor alphaAdhesion molecules E-selectinPro-resolving responseNF-κB p65 subunitPro-inflammatory mediatorsAnti-inflammatory actionPro-inflammatory signalsVascular smooth muscleNecrosis factor alphaAttenuation of TNFHuman saphenous vein ECsHuman vascular endothelialBioactive lipid mediatorsNF-κB activationSmooth muscle cellsTNF-α effectSignaling pathwaysBronchial epithelial cellsIntracellular cyclic AMPTime-dependent increaseVascular inflammation
2013
D‐series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury
Miyahara T, Runge S, Chatterjee A, Chen M, Mottola G, Fitzgerald JM, Serhan CN, Conte MS. D‐series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. The FASEB Journal 2013, 27: 2220-2232. PMID: 23407709, PMCID: PMC3659350, DOI: 10.1096/fj.12-225615.Peer-Reviewed Original ResearchConceptsD-series resolvinsVascular injuryLipid mediatorsNeointimal hyperplasiaBalloon-injured rabbit arteriesMonocyte adhesionVascular smooth muscle cell activationSuperoxide productionSmooth muscle cell activationSpecialized lipid mediatorsExpression of receptorsProinflammatory gene expressionDose-dependent inhibitionMuscle cell activationVascular smooth muscle cell phenotypeSmooth muscle cell phenotypeMuscle cell phenotypeArterial angioplastyLeukocyte recruitmentHuman VSMCsVSMC proliferationGene expression assaysRabbit arteriesVascular homeostasisRvD2