Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications
Wu B, Mottola G, Schaller M, Upchurch GR, Conte MS. Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications. Molecular Aspects Of Medicine 2017, 58: 72-82. PMID: 28765077, PMCID: PMC5660644, DOI: 10.1016/j.mam.2017.07.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecialized pro-resolving lipid mediatorsVascular injuryLipid mediatorsVSMC migrationPro-resolving lipid mediatorsVascular smooth muscle cell activationSmooth muscle cell activationSpecialized lipid mediatorsAcute vascular injuryElaboration of cytokinesDisease-related eventsEndothelial cell disruptionMuscle cell activationImportant clinical contextsClearance of debrisMatrix protein depositionLeukocyte effluxBypass GraftingBypass surgeryBalloon angioplastyLeukocyte recruitmentAneurysm formationInflammatory signalsExperimental aneurysm formationLumen compromise