2013
Met Activation Is Required for Early Cytoprotection after Ischemic Kidney Injury
Mason S, Hader C, Marlier A, Moeckel G, Cantley LG. Met Activation Is Required for Early Cytoprotection after Ischemic Kidney Injury. Journal Of The American Society Of Nephrology 2013, 25: 329-337. PMID: 24136921, PMCID: PMC3904569, DOI: 10.1681/asn.2013050473.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAnimalsApoptosisBcl-Associated Death ProteinGene Knockdown TechniquesKidneyKidney Tubules, ProximalMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutOrgan SpecificityPhosphatidylinositol 3-KinasesPhosphorylationProtein Processing, Post-TranslationalProto-Oncogene Proteins c-aktReceptor Protein-Tyrosine KinasesReperfusion InjuryRibosomal Protein S6 Kinases, 70-kDaSignal TransductionConceptsIschemia/reperfusionKidney injuryIschemic injuryProximal tubulesInitial tubular injuryMET receptor expressionProximal tubule responseTubular cell survivalIschemic kidney injuryProximal tubule epithelial cellsRenal proximal tubule epithelial cellsTubular cell proliferationTubular cell apoptosisPI3K/Akt activationProapoptotic factor BadTubule epithelial cellsCell survivalTubule responseSerum creatinineTubular injuryKidney repairLiver abnormalitiesReceptor expressionInjuryMET activation
2005
Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2) IMPLICATIONS FOR ALTERED DRUG DISPOSITION AND CENTRAL NERVOUS SYSTEM DRUG ENTRY*
Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB. Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2) IMPLICATIONS FOR ALTERED DRUG DISPOSITION AND CENTRAL NERVOUS SYSTEM DRUG ENTRY*. Journal Of Biological Chemistry 2005, 280: 9610-9617. PMID: 15632119, DOI: 10.1074/jbc.m411092200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAmino Acid SubstitutionBrainEnkephalin, D-Penicillamine (2,5)-EstroneHumansKidneyKineticsLiverLiver-Specific Organic Anion Transporter 1Models, MolecularMolecular Sequence DataOligopeptidesOrgan SpecificityPolymorphism, GeneticPolymorphism, Single NucleotideProtein ConformationProtein Structure, SecondaryConceptsTransport activityPlasma membrane expressionCell surface biotinylationBroad substrate specificityGenomic DNA samplesReduced transport activityApparent molecular sizeSingle nucleotide polymorphismsGenetic variationSubstrate specificitySurface biotinylationGlycosylation statusOrganic anion-transporting polypeptide 1A2Substrate-dependent changesNonsynonymous polymorphismsRenal distal nephronMembrane expressionNucleotide polymorphismsG variantDrug uptake transportersSubstrate drugsConfocal microscopyDrug dispositionCentral nervous system entryT variant
2002
A Novel Gene Encoding a TIG Multiple Domain Protein Is a Positional Candidate for Autosomal Recessive Polycystic Kidney Disease
Xiong H, Chen Y, Yi Y, Tsuchiya K, Moeckel G, Cheung J, Liang D, Tham K, Xu X, Chen XZ, Pei Y, Zhao ZJ, Wu G. A Novel Gene Encoding a TIG Multiple Domain Protein Is a Positional Candidate for Autosomal Recessive Polycystic Kidney Disease. Genomics 2002, 80: 96-104. PMID: 12079288, DOI: 10.1006/geno.2002.6802.Peer-Reviewed Original ResearchConceptsNorthern blot analysisNovel genesGenetic intervalStrong positional candidate geneMultiple alternative transcriptsExpression of PKHD1Positional candidate genesAutosomal recessive polycystic kidney diseaseBlot analysisImmunoglobulin-like foldGenetic linkage analysisTIG domainMultiple-domain proteinsDomain proteinsSitu hybridization analysisGenomic regionsPolycystic kidney diseaseAlternative transcriptsPositional candidatesRecessive polycystic kidney diseaseCommon hereditary renal cystic diseasesHepatic disease 1Gene productsCloning strategyCandidate genes