2007
Overexpression of Cyclooxygenase-2 Predisposes to Podocyte Injury
Cheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC. Overexpression of Cyclooxygenase-2 Predisposes to Podocyte Injury. Journal Of The American Society Of Nephrology 2007, 18: 551-559. PMID: 17202413, DOI: 10.1681/asn.2006090990.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclooxygenase 2DoxorubicinGene Expression Regulation, EnzymologicKidneyKidney GlomerulusMembrane ProteinsMiceMice, Inbred BALB CMice, TransgenicPodocytesPolymerase Chain ReactionPromoter Regions, GeneticConceptsCOX-2 expressionBALB/c miceFoot process effacementTransgenic miceC micePodocyte injuryProcess effacementCOX-2 transgenic miceImmunoreactive COX-2 expressionCOX-2 mRNA expressionNephrin promoterLong-term treatmentCOX-2 overexpressionTransgenic mouse kidneyCyclooxygenase-2 expressionWild-type miceWild-type littermatesCOX-2 mRNARenal injuryRenal ablationAdriamycin nephropathyMore albuminuriaAdriamycin administrationFurther injuryCOX-2
2003
Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress
Lamitina ST, Morrison R, Moeckel GW, Strange K. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress. American Journal Of Physiology - Cell Physiology 2003, 286: c785-c791. PMID: 14644776, DOI: 10.1152/ajpcell.00381.2003.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCaenorhabditis elegansGene Expression Regulation, EnzymologicGlycerolGlycerol-3-Phosphate Dehydrogenase (NAD+)Glycerolphosphate DehydrogenaseOsmotic PressureSaline Solution, HypertonicWater-Electrolyte BalanceConceptsExtreme osmotic stressOsmotic stressCell osmoregulationHypertonic stressFunctional genomic analysisNematode Caenorhabditis elegansOrganic osmolyte glycerolPowerful model systemNumerous experimental advantagesCellular osmotic homeostasisCaenorhabditis elegansC. elegansCellular lifeNematode CaenorhabditisOsmolyte glycerolGenomic analysisOsmotic homeostasisGenetic basisOsmotic adaptationTranscriptional expressionOsmotic balanceMolecular understandingAccumulation of glycerolGlycerol accumulationNaCl agar