2013
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy
Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.Peer-Reviewed Original ResearchConceptsProgressive renal failureRenal failureCalcium oxalate crystal depositionCrystal-associated diseasesOverproduction of oxalateWild-type miceHigh-oxalate dietNephropathy resultsOxalate nephropathyRenal histologyKidney diseaseOxalate dietInflammatory responseNALP3 expressionDietary oxalateIntestinal oxalateOxalate homeostasisSoluble oxalateNephropathyCrystal depositionMiceMultiple disordersNALP3DietInflammation
1997
Kidney-targeted liposome-mediated gene transfer in mice
Lai L, Moeckel G, Lien Y. Kidney-targeted liposome-mediated gene transfer in mice. Gene Therapy 1997, 4: 426-431. PMID: 9274719, DOI: 10.1038/sj.gt.3300406.Peer-Reviewed Original ResearchConceptsBlood urea nitrogen levelsUrea nitrogen levelsRenal tubular cellsTubular epithelial cellsGene therapyRenal histologyLeft kidneyArterial injectionArterial groupParenchymal groupTubular cellsGene transferParenchymal injectionOuter medullaD-galactopyranoside stainingKidneyEpithelial cellsInterstitial compartmentCytomegalovirus immediate-early gene promoterInjectionLiposome-mediated gene deliveryTherapyΒ-galactosidase expressionTransient gene transferImmediate-early gene promoter