2011
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli M, Yan Z, McEwen BS, Sanacora G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nature Reviews Neuroscience 2011, 13: 22-37. PMID: 22127301, PMCID: PMC3645314, DOI: 10.1038/nrn3138.Peer-Reviewed Original ResearchConceptsGlutamate releaseGlutamate transmissionAcute stressCognitive functionPrefrontal cortexPrefrontal cortex-dependent cognitive functionsGlutamatergic synaptic transmissionLimbic brain areasGlutamatergic neurotransmitter systemChronic stress exposureUnmet therapeutic needMonoaminergic mechanismsNeurochemical mediatorsCertain cognitive functionsLimbic regionsPrimary neurotransmitterNMDA receptorsGlutamate receptorsNeurotransmitter systemsPharmacological interventionsSynaptic transmissionGlutamate synapseMaladaptive changesBrain areasBrain tissue
1998
Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography
Malison R, Price L, Berman R, van Dyck C, Pelton G, Carpenter L, Sanacora G, Owens M, Nemeroff C, Rajeevan N, Baldwin R, Seibyl J, Innis R, Charney D. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography. Biological Psychiatry 1998, 44: 1090-1098. PMID: 9836013, DOI: 10.1016/s0006-3223(98)00272-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsBrainBrain StemCarrier ProteinsCocaineDepressive DisorderFemaleHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsParoxetinePsychiatric Status Rating ScalesSerotoninSerotonin Plasma Membrane Transport ProteinsTomography, Emission-Computed, Single-PhotonConceptsDepressed patientsMajor depressionHealthy subjectsBrain serotonin transporter availabilitySerotonin transporterBeta-CIT SPECTDensity of brainPost-mortem brain tissuePathophysiology of depressionSerotonin transporter availabilityUnipolar major depressionBeta-CIT bindingSingle photon emissionSerotonergic neuronsBrain uptakeSERT availabilityTransporter availabilityBeta-CITBrain tissueCarbomethoxy-3βPatientsBlood plateletsDepressionPhoton emissionSignificant reduction