Prefrontal cortex astroglia modulate anhedonia-like behavior
Codeluppi S, Xu M, Bansal Y, Lepack A, Duric V, Chow M, Muir J, Bagot R, Licznerski P, Wilber S, Sanacora G, Sibille E, Duman R, Pittenger C, Banasr M. Prefrontal cortex astroglia modulate anhedonia-like behavior. Molecular Psychiatry 2023, 28: 4632-4641. PMID: 37696873, PMCID: PMC10914619, DOI: 10.1038/s41380-023-02246-1.Peer-Reviewed Original ResearchGlial fibrillary acidic proteinAnhedonia-like behaviorPrefrontal cortexCell depletionDiphtheria toxin administrationDepressive-like behaviorChronic stress modelTreatment of depressionDiphtheria toxin receptorFibrillary acidic proteinDevelopment of anhedoniaCortical astrogliaToxin administrationDesigner receptorsCell activityAcidic proteinViral expressionToxin receptorDesigner drugsExperimental depletionAstrogliaDeficitsReceptorsDepressionCritical roleProphylactic Efficacy of Riluzole against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models
Bansal Y, Fee C, Misquitta K, Codeluppi S, Sibille E, Berman R, Coric V, Sanacora G, Banasr M. Prophylactic Efficacy of Riluzole against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models. Complex Psychiatry 2023, 9: 57-69. PMID: 37101541, PMCID: PMC10123365, DOI: 10.1159/000529534.Peer-Reviewed Original ResearchUnpredictable chronic mild stressAnhedonia-like behaviorHelplessness-like behaviorStress-related disordersFirst-line antidepressant drugsNovelty-induced hypophagia testDepressive-like behaviorChronic mild stressHigh relapse rateSucrose consumption testNovelty-suppressed feedingRodent stress modelsMajor depressive disorderAnxiety-like behaviorOpen field testBehavioral emotionalityRiluzole efficacyRiluzole treatmentHypophagia testRelapse rateProphylactic medicationStress-related illnessesProphylactic efficacyProphylactic treatmentSpecific symptom dimensions