1999
NMR Studies on the Mechanism of Insulin Resistance
Perseghin G, Petersen K, Shulman G. NMR Studies on the Mechanism of Insulin Resistance. Contemporary Endocrinology 1999, 159-177. DOI: 10.1007/978-1-59259-716-1_9.Peer-Reviewed Original ResearchInsulin regulationMuscle glucose metabolismNew insightsNuclear magnetic resonance spectroscopyRecent studies
1998
A novel 13C NMR method to assess intracellular glucose concentration in muscle, in vivo
Cline G, Jucker B, Trajanoski Z, Rennings A, Shulman G. A novel 13C NMR method to assess intracellular glucose concentration in muscle, in vivo. American Journal Of Physiology 1998, 274: e381-e389. PMID: 9486172, DOI: 10.1152/ajpendo.1998.274.2.e381.Peer-Reviewed Original Research
1995
Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver
Petersen K, Blair J, Shulman G. Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver. Metabolism 1995, 44: 1380-1383. PMID: 7476321, DOI: 10.1016/0026-0495(95)90133-7.Peer-Reviewed Original ResearchConceptsMalic enzymeRelative carbon fluxPyruvate kinaseCarbon fluxesAlanine C2Pyruvate carboxylase fluxSubstrate cyclingKinase activityMalic enzyme activityPyruvate kinase activityPyruvate carboxylaseKinaseEnzymeEnzyme activityCarboxylaseNormal rat liverRat liverNuclear magnetic resonance spectroscopyRelative rolesT3 treatmentOxaloacetateCyclingRecirculating systemPyruvate
1992
Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance Spectroscopy
Petroff O, Novotny E, Avison M, Rothman D, Alger J, Ogino T, Shulman G, Prichard J. Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 1022-1029. PMID: 1400641, DOI: 10.1038/jcbfm.1992.139.Peer-Reviewed Original ResearchConceptsBlood lactateLactate poolNuclear magnetic resonance spectroscopyMetabolic stateBrain lactateBlood gasesBlood glucoseElevated lactateMagnetic resonance spectroscopyProlonged elevationRabbit brainPerchloric acid extractsPathological conditionsBrain activationBrainResonance spectroscopyLactate turnoverHigh resolution 1H NMRIntracellular pHElectroshockLactateHuman brainVivo 1HSignificant changesAcid extractsValidation of 13c nmr measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples
Taylor R, Price T, Rothman D, Shulman R, Shulman G. Validation of 13c nmr measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magnetic Resonance In Medicine 1992, 27: 13-20. PMID: 1435198, DOI: 10.1002/mrm.1910270103.Peer-Reviewed Original ResearchConceptsDirect biochemical assaysVivo 13C NMR measurementsHuman skeletal muscleBiochemical assaysSkeletal muscleSkeletal muscle glycogenFatty acidsNuclear magnetic resonance spectroscopyMuscle biopsy