2014
Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational study
Thomas TA, Heysell SK, Moodley P, Montreuil R, Ha X, Friedland G, Bamber SA, Moll AP, Gandhi N, Brant WE, Sturm W, Shah S. Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational study. BMC Infectious Diseases 2014, 14: 11. PMID: 24400822, PMCID: PMC3890632, DOI: 10.1186/1471-2334-14-11.Peer-Reviewed Original ResearchConceptsDrug susceptibility testingGastric aspiratesTB suspectsObservational studySpecimen collectionDrug-susceptible TBNew TB suspectsPediatric TB suspectsTB treatment historyXDR-TB casesMultiple specimen typesYears of ageSame-day methodTB settingsInduced sputumPersistent symptomsSputum inductionTB treatmentHIV statusNegative childrenTB diagnosisUrine cultureMean ageInpatient settingDiagnostic yield
2010
Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study
Heysell SK, Thomas TA, Gandhi NR, Moll AP, Eksteen FJ, Coovadia Y, Roux L, Babaria P, Lalloo U, Friedland G, Shah S. Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study. BMC Infectious Diseases 2010, 10: 344. PMID: 21134279, PMCID: PMC3016377, DOI: 10.1186/1471-2334-10-344.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsChildChild, PreschoolCross-Sectional StudiesExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansInfantInfant, NewbornMaleMiddle AgedMycobacterium tuberculosisRetrospective StudiesRisk FactorsRural PopulationSouth AfricaSputumYoung AdultConceptsDrug-resistant TBMycobacterial blood culturesDrug-resistant tuberculosisBlood culturesXDR-TBRural South AfricaMDR-TBM. tuberculosisMycobacterium tuberculosis bacteremiaCross-sectional studyPositive blood culturesDiagnosis of MDRCross-sectional analysisAntiretroviral therapySecondary outcomesSputum cultureTB suspectsRisk factorsPatientsHIVTuberculosisDiagnosisTBSimilar settingsBacteremiaExtensively drug-resistant tuberculosis in children with human immunodeficiency virus in rural South Africa.
Thomas TA, Shenoi SV, Heysell SK, Eksteen FJ, Sunkari VB, Gandhi NR, Friedland G, Shah NS. Extensively drug-resistant tuberculosis in children with human immunodeficiency virus in rural South Africa. The International Journal Of Tuberculosis And Lung Disease 2010, 14: 1244-51. PMID: 20843414, PMCID: PMC3030274.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusXDR-TB diagnosisXDR-TBDrug-resistant tuberculosisPediatric wardImmunodeficiency virusRural South AfricaXDR-TB patientsXDR-TB treatmentActive antiretroviral therapySputum culture conversionNeuropsychiatric side effectsHospital pediatric wardInfection control policiesCulture conversionAntiretroviral therapyRadiographic improvementNosocomial transmissionOverlapping toxicitiesMicrobiologic dataHIV treatmentMedical recordsMicrobiologic diagnosisHIV therapyPrevious historyOpportunities afforded by new drugs for tuberculosis
Churchyard GJ, Friedland G, Fielding K, Nardell E. Opportunities afforded by new drugs for tuberculosis. The Lancet Infectious Diseases 2010, 10: 368-369. PMID: 20510274, DOI: 10.1016/s1473-3099(10)70095-5.Peer-Reviewed Original Research
2007
Implementation Issues in Tuberculosis/HIV Program Collaboration and Integration: 3 Case Studies
Friedland G, Harries A, Coetzee D. Implementation Issues in Tuberculosis/HIV Program Collaboration and Integration: 3 Case Studies. The Journal Of Infectious Diseases 2007, 196: s114-s123. PMID: 17624820, DOI: 10.1086/518664.Peer-Reviewed Original ResearchConceptsTB/HIV service integrationHIV service integrationNeeds of patientsPublic health approachWorld Health OrganizationHIV diseaseNational TuberculosisHIV programsHIV interactionsInfection influenceHealth approachSuccessful outcomeTuberculosisDiseaseHealth OrganizationLarge national programProgram settingsSmall demonstration projectsMost settingsOutcomesImplementation of programsProgram collaborationNational programLarge populationService integration
1996
Invasive Pneumococcal Disease: Clinical Features, Serotypes, and Antimicrobial Resistance Patterns in Cases Involving Patients with and Without Human Immunodeficiency Virus Infection
Frankel R, Virata M, Hardalo C, Altice F, Friedland G. Invasive Pneumococcal Disease: Clinical Features, Serotypes, and Antimicrobial Resistance Patterns in Cases Involving Patients with and Without Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 1996, 23: 577-584. PMID: 8879783, DOI: 10.1093/clinids/23.3.577.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal diseaseClinical featuresPenicillin-resistant pneumococcal infectionsHuman immunodeficiency virus (HIV) diseaseHuman immunodeficiency virus (HIV) infectionCommon capsular typesSource of bacteremiaImmunodeficiency virus infectionOverall mortality rateAntibiotic susceptibility patternPolyvalent pneumococcal vaccineType 9VCommon risk factorsPenicillin-resistant isolatesAntimicrobial resistance patternsPneumococcal infectionPneumococcal vaccineHIV infectionHIV serostatusHIV statusRecurrence rateInvasive diseaseRisk factorsSusceptibility patterns
1990
Additional evidence for lack of transmission of HIV infection by close interpersonal (casual) contact
Friedland G, Kahl P, Saltzman B, Rogers M, Feiner C, Mayers M, Schable C, Klein R. Additional evidence for lack of transmission of HIV infection by close interpersonal (casual) contact. AIDS 1990, 4: 639-644. PMID: 2118767, DOI: 10.1097/00002030-199007000-00005.Peer-Reviewed Original ResearchConceptsHousehold contactsHIV infectionAIDS patientsClose interpersonal contactNon-sexual contactsPossibility of transmissionAdult patientsHIV antibodiesMedian durationMedian timeP24 antigenHIV transmissionPhysical examinationSerum antibodiesPatientsLast contactLack of transmissionLast evaluationInitial evaluationMonthsInfectionHIVSymptomsAntigenAIDS
1986
Lack of Transmission of HTLV-III/LAV Infection to Household Contacts of Patients with AIDS or AIDS-Related Complex with Oral Candidiasis
Friedland G, Saltzman B, Rogers M, Kahl P, Lesser M, Mayers M, Klein R. Lack of Transmission of HTLV-III/LAV Infection to Household Contacts of Patients with AIDS or AIDS-Related Complex with Oral Candidiasis. New England Journal Of Medicine 1986, 314: 344-349. PMID: 3456076, DOI: 10.1056/nejm198602063140604.Peer-Reviewed Original ResearchConceptsHTLV-III/LAVHousehold contactsOral candidiasisHuman T-cell lymphotropic virus type III/lymphadenopathy-associated virusHTLV-III/LAV infectionType III/lymphadenopathy-associated virusNonsexual household contactsLymphadenopathy-associated virusEvidence of infectionRisk of infectionRisk of transmissionNonsexual contactImmunodeficiency syndromeAIDS patientsPhysical examinationSerum antibodiesIndex patientsPatientsLack of transmissionSexual partnersAIDSInfectionFive-year-old childrenCandidiasisSame household