2022
Adherence Measured Using Electronic Dose Monitoring is Associated with Emergent Antiretroviral Resistance and Poor Outcomes in People with Human Immunodeficiency Virus/AIDS and Multidrug-Resistant Tuberculosis
Bateman M, Wolf A, Chimukangara B, Brust JCM, Lessells R, Amico R, Boodhram R, Singh N, Orrell C, Friedland G, Naidoo K, Padayatchi N, O’Donnell MR. Adherence Measured Using Electronic Dose Monitoring is Associated with Emergent Antiretroviral Resistance and Poor Outcomes in People with Human Immunodeficiency Virus/AIDS and Multidrug-Resistant Tuberculosis. Clinical Infectious Diseases 2022, 75: 1489-1496. PMID: 35352097, PMCID: PMC9617578, DOI: 10.1093/cid/ciac232.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisHuman immunodeficiency virusMDR-TB treatmentART adherenceART resistanceHuman immunodeficiency virus/AIDSEmergent resistanceStandard of careResource-limited settingsTB regimensAntiretroviral resistanceHIV RNAProspective cohortMedication adherenceImmunodeficiency virusPoor outcomeShort followAdherence thresholdCopies/Treatment outcomesDose monitoringResistance mutationsResistance testingPublic hospitalsLinear association
2016
Impact of nurse-delivered community-based CD4 services on facilitating pre-ART care in rural South Africa
Kompala T, Moll AP, Mtungwa N, Brooks RP, Friedland GH, Shenoi SV. Impact of nurse-delivered community-based CD4 services on facilitating pre-ART care in rural South Africa. BMC Health Services Research 2016, 16: 374. PMID: 27515233, PMCID: PMC4982129, DOI: 10.1186/s12913-016-1627-8.Peer-Reviewed Original ResearchConceptsPre-ART careAntiretroviral treatmentCD4 testingCBVCT servicesTreatment cascadeRural South AfricaLocal primary care clinicsCD4 count resultsCommunity-based voluntary counselingPrimary care clinicsHIV-positive clientsPhlebotomy servicesResource-limited settingsART initiationHIV careART eligibilityCare cascadeCare clinicsHIV-positiveVoluntary counselingTreatment eligibilityCD4 resultsResult notificationResultsBetween 2010Nurse presence
2015
What motivates use of community-based human immunodeficiency virus testing in rural South Africa?
Upadhya D, Moll AP, Brooks RP, Friedland G, Shenoi SV. What motivates use of community-based human immunodeficiency virus testing in rural South Africa? International Journal Of STD & AIDS 2015, 27: 662-671. PMID: 26134323, PMCID: PMC4851612, DOI: 10.1177/0956462415592789.Peer-Reviewed Original ResearchConceptsHIV testingRural South AfricaRural resource-limited settingsHuman immunodeficiency virus (HIV) testingCommunity-based HIVCommunity-based testingMedian CD4 countRecent HIV exposureCommunity-based HIV testing programmeFirst-time testersHIV testing programsVoluntary HIV testingResource-limited settingsCD4 countHIV exposureMedian ageHIV statusVirus testingCommunity testingHIVCells/Rural settingsFamily membersSix-itemRisky lifestyles
2013
‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis
Shenoi SV, Brooks RP, Catterick K, Moll AP, Friedland GH. ‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis. Public Health Action 2013, 3: 46-50. PMID: 25392815, PMCID: PMC4226409, DOI: 10.5588/pha.12.0056.Peer-Reviewed Original ResearchGeneral medical clinicDrug-resistant tuberculosisMedical clinicsClinic attendeesTB suspectsHuman immunodeficiency virus (HIV) patientsHigh HIV prevalence settingsZiehl-NeelsenProportion of patientsHIV prevalence settingsCulture-positive casesResource-limited settingsWorld Health OrganizationTB screeningVirus patientsHigh HIVResistant tuberculosisPatient populationTB prevalencePrevalence settingsReferral laboratoryTuberculosisDrug resistancePatientsClinic
2011
Rapid Diagnosis of Tuberculosis and Multidrug Resistance by the Microscopic-Observation Drug-Susceptibility Assay
Shah NS, Moodley P, Babaria P, Moodley S, Ramtahal M, Richardson J, Heysell S, Li X, Moll A, Friedland G, Sturm AW, Gandhi NR. Rapid Diagnosis of Tuberculosis and Multidrug Resistance by the Microscopic-Observation Drug-Susceptibility Assay. American Journal Of Respiratory And Critical Care Medicine 2011, 183: 1427-1433. PMID: 21297071, DOI: 10.1164/rccm.201009-1449oc.Peer-Reviewed Original ResearchConceptsDrug susceptibility testingMDR-TB diagnosisMDR-TBHIV statusMultidrug-resistant (MDR) TBProportion methodRapid diagnosisProspective diagnostic accuracy studyAdult TB suspectsMicroscopic-Observation DrugReference standard cultureMedian CD4 countPatient's HIV statusHIV prevalence settingsIndirect proportion methodMycobacterial growth indicator tube (MGIT) cultureMedian turnaround timeResource-limited settingsReference standardDiagnostic accuracy studiesCD4 countMycobacterium tuberculosis detectionConsecutive adultsTB suspectsHIV prevalenceCulture Conversion Among HIV Co-Infected Multidrug-Resistant Tuberculosis Patients in Tugela Ferry, South Africa
Brust JC, Lygizos M, Chaiyachati K, Scott M, van der Merwe TL, Moll AP, Li X, Loveday M, Bamber SA, Lalloo UG, Friedland GH, Shah NS, Gandhi NR. Culture Conversion Among HIV Co-Infected Multidrug-Resistant Tuberculosis Patients in Tugela Ferry, South Africa. PLOS ONE 2011, 6: e15841. PMID: 21253585, PMCID: PMC3017058, DOI: 10.1371/journal.pone.0015841.Peer-Reviewed Original ResearchConceptsMDR-TB patientsCulture conversion rateMDR-TB treatmentMonths of therapyAntiretroviral therapyHIV-coCulture conversionHIV co-infected patientsMultidrug-resistant tuberculosis patientsTiming of ARTMDR-TB therapyCo-infected patientsHIV-negative patientsSecond-line regimenSimilar cure ratesDays of initiationResource-limited settingsHIV prevalentART medicationsCD4 countMDR-TBTuberculosis patientsSputum cultureSuch patientsHIV status
2010
Transmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts
Shenoi SV, Escombe AR, Friedland G. Transmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts. Clinical Infectious Diseases 2010, 50: s231-s237. PMID: 20397953, PMCID: PMC3029014, DOI: 10.1086/651496.Peer-Reviewed Original ResearchConceptsInfection control strategiesResource-limited settingsHIV infectionInfection controlActive antiretroviral therapy rolloutHuman immunodeficiency virus (HIV) infectionAntiretroviral therapy rolloutTransmission of drugDrug-resistant TBImmunodeficiency virus infectionDrug-resistant tuberculosisHealth care workersAirborne infection controlNosocomial transmissionTuberculosis careVirus infectionCare workersInfectionCurrent outbreakHigh rateTBPotential benefitsMorbidityHIVTuberculosisPreparing for highly active antiretroviral therapy rollout in rural South Africa: an assessment using the information, motivation, and behavioral skills model
Simon MD, Altice FL, Moll AP, Shange M, Friedland GH. Preparing for highly active antiretroviral therapy rollout in rural South Africa: an assessment using the information, motivation, and behavioral skills model. AIDS Care 2010, 22: 462-474. PMID: 20204909, DOI: 10.1080/09540120903220253.Peer-Reviewed Original ResearchConceptsActive antiretroviral therapy rolloutAntiretroviral therapy rolloutHIV/AIDSHAART rolloutHAART outcomesFolk remediesHIV treatment optimismMedication-taking behaviorOverall correct scoreBetter treatment outcomesResource-limited settingsBehavioral skills modelCommunity-based assessmentHAART initiationHIV optimismHIV testingHIV serostatusTreatment optimismTreatment outcomesSide effectsRural South AfricaCondom useHAARTTugela FerryYoung adults
2007
Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling study
Basu S, Andrews JR, Poolman EM, Gandhi NR, Shah NS, Moll A, Moodley P, Galvani AP, Friedland GH. Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling study. The Lancet 2007, 370: 1500-1507. PMID: 17964351, PMCID: PMC3711808, DOI: 10.1016/s0140-6736(07)61636-5.Peer-Reviewed Original ResearchConceptsInfection control strategiesDrug-resistant tuberculosisXDR tuberculosisTuberculosis casesTuberculosis transmissionRural South African district hospitalSouth African district hospitalMask useTugela FerryAfrican district hospitalEffects of HIVInfection control measuresDrug resistance testingCommunity-based dataResource-limited settingsEpidemiological modelling studyCommunity-based programsAntiretroviral therapyNosocomial transmissionHospitalisation timeHIV treatmentOutpatient therapyDistrict hospitalTuberculosis epidemicHospital staff
2004
A Pilot Study of Once-Daily Antiretroviral Therapy Integrated With Tuberculosis Directly Observed Therapy in a Resource-Limited Setting
Jack C, Lalloo U, Karim QA, Karim SA, El-Sadr W, Cassol S, Friedland G. A Pilot Study of Once-Daily Antiretroviral Therapy Integrated With Tuberculosis Directly Observed Therapy in a Resource-Limited Setting. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2004, 36: 929-934. PMID: 15220699, DOI: 10.1097/00126334-200408010-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdolescentAdultAlkynesAnti-HIV AgentsAntibiotics, AntitubercularAntiretroviral Therapy, Highly ActiveBenzoxazinesCosts and Cost AnalysisCyclopropanesDidanosineDrug Therapy, CombinationFemaleHIV InfectionsHumansLamivudineMaleMiddle AgedOutpatient Clinics, HospitalOxazinesPilot ProjectsSouth AfricaTreatment OutcomeTuberculosisUrban PopulationConceptsAntiretroviral therapyTB therapyViral loadPilot studyTwenty HIV-positive patientsSmear-positive pulmonary TBCD4 count increaseDrug-sensitive TBObserved therapy programStandard TB therapyActive antiretroviral therapyHIV-positive patientsMean CD4 countMean viral loadCells/Resource limited settingsResource-limited settingsDaily didanosineHAART regimenCD4 countHIV clinicPulmonary TBTB clinicNeurologic toxicityObserved therapy
2003
Use of Total Lymphocyte Count for Monitoring Response to Antiretroviral Therapy
Schreibman T, Friedland G. Use of Total Lymphocyte Count for Monitoring Response to Antiretroviral Therapy. Clinical Infectious Diseases 2003, 38: 257-262. PMID: 14699459, DOI: 10.1086/380792.Peer-Reviewed Original ResearchConceptsTotal lymphocyte countCD4 cell countAntiretroviral therapyCell countLymphocyte countHuman immunodeficiency virus (HIV) diseaseOpportunistic infection prophylaxisPotential surrogate markerResource-limited settingsHIV diseaseInfection prophylaxisLaboratory markersOpportunistic infectionsSurrogate markerDisease progressionClinical utilityImmune functionTherapeutic interventionsTherapyKey laboratory measurementsMonitoring responseVirus diseaseLack of availabilityDiseaseCount