2012
A Randomized Controlled Trial of Highly Active Antiretroviral Therapy Versus Highly Active Antiretroviral Therapy and Chemotherapy in Therapy-Naive Patients With HIV-Associated Kaposi Sarcoma in South Africa
Mosam A, Shaik F, Uldrick TS, Esterhuizen T, Friedland GH, Scadden DT, Aboobaker J, Coovadia HM. A Randomized Controlled Trial of Highly Active Antiretroviral Therapy Versus Highly Active Antiretroviral Therapy and Chemotherapy in Therapy-Naive Patients With HIV-Associated Kaposi Sarcoma in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2012, 60: 150-157. PMID: 22395672, PMCID: PMC3360837, DOI: 10.1097/qai.0b013e318251aedd.Peer-Reviewed Original ResearchConceptsHIV-KSKing Edward VIII HospitalSymptomatic visceral diseaseActive antiretroviral therapyOpen-label trialTreatment-naive patientsTertiary referral centerAdministration of chemotherapyHAART armUrgent chemotherapyAntiretroviral therapyReferral centerVisceral diseaseTreat analysisKaposi's sarcomaHAARTChemotherapySaharan AfricaOptimal approachHIVLamivudinePatientsSarcomaStavudineNevirapine
2010
HAART and response to therapy improve quality of life (QOL) of African patients with advanced HIV-associated Kaposi’s sarcoma (HIV-KS): a prospective analysis of QOL in the KAART trial
Mosam A, Shaik F, Uldrick T, Esterhuizen T, Friedland G, Scadden D, Aboobaker J, Coovadia H. HAART and response to therapy improve quality of life (QOL) of African patients with advanced HIV-associated Kaposi’s sarcoma (HIV-KS): a prospective analysis of QOL in the KAART trial. Infectious Agents And Cancer 2010, 5: a30. PMCID: PMC3002689, DOI: 10.1186/1750-9378-5-s1-a30.Peer-Reviewed Original ResearchThe KAART Trial: a randomized controlled trial of HAART compared to the combination of HAART and \chemotherapy in treatment-naïve patients with HIV-associated Kaposi sarcoma (HIV-KS) in KwaZulu-Natal (KZN), South Africa
Mosam A, Shaik F, Uldrick T, Friedland G, Scadden D, Aboobaker J, Coovadia H. The KAART Trial: a randomized controlled trial of HAART compared to the combination of HAART and \chemotherapy in treatment-naïve patients with HIV-associated Kaposi sarcoma (HIV-KS) in KwaZulu-Natal (KZN), South Africa. Infectious Agents And Cancer 2010, 5: a80. PMCID: PMC3002744, DOI: 10.1186/1750-9378-5-s1-a80.Peer-Reviewed Original Research
2009
Prognosis of patients with AIDS-associated Kaposi's sarcoma receiving antiretroviral therapy +/- chemotherapy in Kwazulu-Natal, South Africa: an analysis of 1-yr survival data from NCT00380770
Uldrick T, Mosam A, Shaik F, Friedland G, Skadden D, Jordaan J, Aboobaker J, Coovadia H. Prognosis of patients with AIDS-associated Kaposi's sarcoma receiving antiretroviral therapy +/- chemotherapy in Kwazulu-Natal, South Africa: an analysis of 1-yr survival data from NCT00380770. Infectious Agents And Cancer 2009, 4: p41. PMCID: PMC4261824, DOI: 10.1186/1750-9378-4-s2-p41.Peer-Reviewed Original Research
2008
Characteristics of HIV-1-associated Kaposi's sarcoma among women and men in South Africa
Mosam A, Hurkchand H, Cassol E, Page T, Cassol S, Bodasing U, Aboobaker J, Dawood H, Friedland G, Coovadia H. Characteristics of HIV-1-associated Kaposi's sarcoma among women and men in South Africa. International Journal Of STD & AIDS 2008, 19: 400-405. PMID: 18595878, DOI: 10.1258/ijsa.2008.007301.Peer-Reviewed Original ResearchConceptsHIV-1-associated Kaposi's sarcomaKaposi's sarcomaCD4/CD8 cell countsHIV-1 viral loadCD8 cell countsCutaneous Kaposi's sarcomaPoor disease prognosisVirological featuresViral loadClinical parametersPatients 99Male ratioSevere diseaseDisease prognosisCell countSarcomaHIVDescriptive studyAfrican settingEqual femalePatientsOne-thirdDiseaseFemalesWomen
2005
Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa
Mosam A, Cassol E, Page T, Bodasing U, Cassol S, Dawood H, Friedland GH, Scadden DT, Aboobaker J, Jordaan JP, Lalloo UG, Esterhuizen TM, Coovadia HM. Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa. AIDS 2005, 19: 441-443. PMID: 15750399, DOI: 10.1097/01.aids.0000161775.36652.85.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyKaposi's sarcomaCopies/Generic antiretroviral therapyUndetectable viral loadActive antiretroviral therapyGeneric antiretroviral drugsAntiretroviral efficacyViral loadAntiretroviral drugsLog10 declineClinical experienceSarcomaTherapySaharan AfricaSub-Saharan AfricaHIVPatientsAIDSBaseline
2004
Therapeutic Response of HIV-1 Subtype C in African Patients Coinfected with either Mycobacterium tuberculosis or Human Herpesvirus-8
Cassol E, Page T, Mosam A, Friedland G, Jack C, Lalloo U, Kopetka J, Patterson B, Esterhuizen T, Coovadia HM. Therapeutic Response of HIV-1 Subtype C in African Patients Coinfected with either Mycobacterium tuberculosis or Human Herpesvirus-8. The Journal Of Infectious Diseases 2004, 191: 324-332. PMID: 15633090, DOI: 10.1086/427337.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsAnti-HIV AgentsCD4 Lymphocyte CountDrug Therapy, CombinationFemaleHerpesvirus 8, HumanHIV InfectionsHIV-1HumansMaleMiddle AgedMycobacterium tuberculosisReverse Transcriptase InhibitorsRNA, ViralSarcoma, KaposiTreatment OutcomeTuberculosis, PulmonaryViral LoadConceptsKaposi's sarcomaHIV-1Opportunistic infectionsViral loadAfrican patientsUndetectable HIV-1 RNA levelsCell countHIV-1 RNA levelsPlasma HIV-1 levelsHuman immunodeficiency virus (HIV) infectionHIV-1 subtype CKaplan-Meier survival analysisMycobacterium tuberculosisHIV-1 levelsImmunodeficiency virus infectionProportion of patientsTarget cell availabilityHuman herpesvirus 8Immune activationTreatment regimensSubtype CTherapeutic responseTreatment outcomesVirus infectionHerpesvirus 8
1991
Survival differences in patients with AIDS.
Friedland G, Saltzman B, Vileno J, Freeman K, Schrager L, Klein R. Survival differences in patients with AIDS. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1991, 4: 144-53. PMID: 1987352.Peer-Reviewed Original ResearchConceptsPneumocystis carinii pneumoniaFavorable survivalCarinii pneumoniaMale sexYounger ageRisk behaviorsInitial AIDS diagnosisSingle medical centerIntravenous drug usePoint of diagnosisInitial AIDSMedian survivalAIDS diagnosisBlack raceSurvival differencesKaposi's sarcomaMedical CenterClinical carePatientsDrug useAIDSSurvivalDiagnosisPowerful predictorMonths
1987
Oral findings in patients with acquired immunodeficiency syndrome
Phelan J, Saltzman B, Friedland G, Klein R. Oral findings in patients with acquired immunodeficiency syndrome. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 1987, 64: 50-56. PMID: 3475658, DOI: 10.1016/0030-4220(87)90116-2.Peer-Reviewed Original ResearchConceptsImmunodeficiency syndromeKaposi's sarcomaBisexual menPerioral molluscum contagiosumExfoliative cheilitisGingival bleedingOral findingsConsecutive patientsHeterosexual patientsMolluscum contagiosumOral candidiasisCommon findingOral examinationUncertain causePatientsHairy tongueSarcomaLeukoplakiaSignificant differencesSubsequent examinationSyndromeAIDSMenExaminationFindings
1984
Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency Syndrome
Klein R, Harris C, Small C, Moll B, Lesser M, Friedland G. Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency Syndrome. New England Journal Of Medicine 1984, 311: 354-358. PMID: 6738653, DOI: 10.1056/nejm198408093110602.Peer-Reviewed Original ResearchConceptsT4/T8 ratioOral candidiasisT8 ratioImmunodeficiency syndromeOpportunistic infectionsHigh-risk patientsMajor opportunistic infectionIntravenous drug abusersAcquired Immunodeficiency SyndromeSerious opportunistic infectionsGeneralized lymphadenopathyInitial manifestationSimilar patientsKaposi's sarcomaHigh riskPatientsHealthy adultsCandidiasisLymphadenopathyBisexual menAIDSSarcomaSyndromeInfectionMonths