2015
Trends in hospital deaths among human immunodeficiency virus–infected patients during the antiretroviral therapy era, 1995 to 2011
Cowell A, Shenoi SV, Kyriakides TC, Friedland G, Barakat LA. Trends in hospital deaths among human immunodeficiency virus–infected patients during the antiretroviral therapy era, 1995 to 2011. Journal Of Hospital Medicine 2015, 10: 608-614. PMID: 26130520, PMCID: PMC4560992, DOI: 10.1002/jhm.2409.Peer-Reviewed Original ResearchConceptsHospital deathAIDS deathsHuman immunodeficiency virus-infected patientsHigher CD4 cell countsAIDS infectionAntiretroviral therapy eraNon-AIDS deathsNon-AIDS malignanciesCD4 cell countHIV viral loadVirus-infected patientsHuman immunodeficiency virusUrban teaching hospitalTimes greater likelihoodCardiovascular comorbiditiesTherapy eraCD4 countInpatient mortalityImmunodeficiency syndromeLiver diseaseUnderlying liverViral loadImmunodeficiency virusMedical recordsAntiretroviral era
2011
Integration of Antiretroviral Therapy with Tuberculosis Treatment
Abdool Karim S, Naidoo K, Grobler A, Padayatchi N, Baxter C, Gray AL, Gengiah T, Gengiah S, Naidoo A, Jithoo N, Nair G, El-Sadr WM, Friedland G, Abdool Karim Q. Integration of Antiretroviral Therapy with Tuberculosis Treatment. New England Journal Of Medicine 2011, 365: 1492-1501. PMID: 22010915, PMCID: PMC3233684, DOI: 10.1056/nejmoa1014181.Peer-Reviewed Original ResearchConceptsImmune reconstitution inflammatory syndromeT-cell countsEarly ART groupLater-ART groupInitiation of ARTAntiretroviral therapyTuberculosis treatmentIncidence rateCubic millimeterAdverse eventsRisk of IRISHuman immunodeficiency virus (HIV) infectionReconstitution inflammatory syndromeMedian viral loadImmunodeficiency virus infectionAIDS-free survivalRisk of AIDSHigher CD4Median CD4Inflammatory syndromeAmbulatory patientsImmunodeficiency syndromeViral loadContinuation phaseAntiretroviral drugs
1994
Maturity of human immunodeficiency virus infection and incubation period of acquired immunodeficiency syndrome in injecting drug users
Alcabes P, Muñoz A, Vlahov D, Friedland G. Maturity of human immunodeficiency virus infection and incubation period of acquired immunodeficiency syndrome in injecting drug users. Annals Of Epidemiology 1994, 4: 17-26. PMID: 7911376, DOI: 10.1016/1047-2797(94)90038-8.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBaltimoreCD4-Positive T-LymphocytesCohort StudiesConfidence IntervalsHIV InfectionsHIV SeroprevalenceHomosexualityHumansIncidenceLeukocyte CountLife TablesMaleModels, StatisticalNew York CityPlatelet CountRegression AnalysisSubstance Abuse, IntravenousSurvival RateTime FactorsConceptsHIV infectionDrug usersImmunodeficiency syndromeMedian timeCombined cohortHomosexual menHuman immunodeficiency virus (HIV) infectionHuman immunodeficiency virus (HIV) epidemicPercent of CD4Immunodeficiency virus infectionIncident HIV infectionProduct-limit methodMarkers of maturityHIV incubation distributionsPlatelet countVirus infectionLarge cohortSeroconversionCohortInfectionConfidence intervalsIncubation distributionAIDSVirus epidemicPopulation groups
1991
Demographic characteristics, drug use, and sexual behavior of i.v. drug user with AIDS in Bronx, New York.
Schrager L, Friedland G, Feiner C, Kahl P. Demographic characteristics, drug use, and sexual behavior of i.v. drug user with AIDS in Bronx, New York. Public Health Reports 1991, 106: 78-84. PMID: 1899944, PMCID: PMC1580205.Peer-Reviewed Original ResearchConceptsDrug usersDemographic characteristicsDrug useHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionIntravenous drug usersMontefiore Medical CenterMethadone maintenance programSharing of needlesInjection of drugsSexual behaviorDrug use behaviorsDrug use practicesHIV infectionImmunodeficiency syndromeVirus infectionMedical CenterEpidemiologic informationShooting galleriesCocaine useAIDSInjection episodesSexual practicesEarly ageInfection
1988
AIDS and Compassion
Friedland G. AIDS and Compassion. JAMA 1988, 259: 2898-2899. PMID: 3367458, DOI: 10.1001/jama.1988.03720190066034.Peer-Reviewed Original ResearchLow Occupational Risk of Human Immunodeficiency Virus Infection among Dental Professionals
Klein R, Phelan J, Freeman K, Schable C, Friedland G, Trieger N, Steigbigel N. Low Occupational Risk of Human Immunodeficiency Virus Infection among Dental Professionals. New England Journal Of Medicine 1988, 318: 86-90. PMID: 3422106, DOI: 10.1056/nejm198801143180205.Peer-Reviewed Original ResearchMeSH KeywordsAccidents, OccupationalAcquired Immunodeficiency SyndromeAntibodies, ViralDental AssistantsDental HygienistsDentistryFemaleHepatitis B Surface AntigensHIV AntibodiesHumansMaleNew York CityOccupational DiseasesProfessional PracticePuncturesRisk FactorsSkinSurveys and QuestionnairesUnited StatesConceptsHuman immunodeficiency virusHepatitis B surface antigenBehavioral risk factorsInfection control practicesB surface antigenLow occupational riskDental professionalsOccupational riskHIV infectionRisk factorsOccupational exposureSurface antigenHuman immunodeficiency virus (HIV) infectionFrequent occupational exposureImmunodeficiency virus infectionInfection control precautionsCases of AIDSPotential occupational exposureUnvaccinated subjectsImmunodeficiency syndromeImmunodeficiency virusSerum antibodiesVirus infectionDental practiceSharp instruments
1987
Oral findings in patients with acquired immunodeficiency syndrome
Phelan J, Saltzman B, Friedland G, Klein R. Oral findings in patients with acquired immunodeficiency syndrome. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 1987, 64: 50-56. PMID: 3475658, DOI: 10.1016/0030-4220(87)90116-2.Peer-Reviewed Original ResearchConceptsImmunodeficiency syndromeKaposi's sarcomaBisexual menPerioral molluscum contagiosumExfoliative cheilitisGingival bleedingOral findingsConsecutive patientsHeterosexual patientsMolluscum contagiosumOral candidiasisCommon findingOral examinationUncertain causePatientsHairy tongueSarcomaLeukoplakiaSignificant differencesSubsequent examinationSyndromeAIDSMenExaminationFindingsThe Acquired Immunodeficiency Syndrome: General Overview
Friedland G. The Acquired Immunodeficiency Syndrome: General Overview. International Journal Of Neuroscience 1987, 32: 677-686. PMID: 3647936, DOI: 10.3109/00207458709043322.Peer-Reviewed Original Research
1986
Mycobacterium tuberculosis Bacteremia in the Acquired Immunodeficiency Syndrome
Saltzman B, Motyl M, Friedland G, McKitrick J, Klein R. Mycobacterium tuberculosis Bacteremia in the Acquired Immunodeficiency Syndrome. JAMA 1986, 256: 390-391. PMID: 3088290, DOI: 10.1001/jama.1986.03380030092036.Peer-Reviewed Original ResearchConceptsAcquired Immunodeficiency SyndromeImmunodeficiency syndromeCellular immunityM tuberculosisMycobacterium avium-intracellulare infectionDisease Control case definitionMycobacterium tuberculosis bacteremiaIntravenous drug abusersUnusual malignant neoplasmFive-year historyIntravenous heroinOpportunistic infectionsDisseminated infectionMalignant neoplasmsCase definitionBacteremiaCocaine abuseDrug abusersBacterial infectionsInfectionMycobacterium tuberculosisWeight lossTuberculosisPatientsSyndromeLack of Transmission of HTLV-III/LAV Infection to Household Contacts of Patients with AIDS or AIDS-Related Complex with Oral Candidiasis
Friedland G, Saltzman B, Rogers M, Kahl P, Lesser M, Mayers M, Klein R. Lack of Transmission of HTLV-III/LAV Infection to Household Contacts of Patients with AIDS or AIDS-Related Complex with Oral Candidiasis. New England Journal Of Medicine 1986, 314: 344-349. PMID: 3456076, DOI: 10.1056/nejm198602063140604.Peer-Reviewed Original ResearchConceptsHTLV-III/LAVHousehold contactsOral candidiasisHuman T-cell lymphotropic virus type III/lymphadenopathy-associated virusHTLV-III/LAV infectionType III/lymphadenopathy-associated virusNonsexual household contactsLymphadenopathy-associated virusEvidence of infectionRisk of infectionRisk of transmissionNonsexual contactImmunodeficiency syndromeAIDS patientsPhysical examinationSerum antibodiesIndex patientsPatientsLack of transmissionSexual partnersAIDSInfectionFive-year-old childrenCandidiasisSame household
1985
Intravenous Drug Abusers and the Acquired Immunodeficiency Syndrome (AIDS): Demographic, Drug Use, and Needle-Sharing Patterns
Friedland G, Harris C, Butkus-Small C, Shine D, Moll B, Darrow W, Klein R. Intravenous Drug Abusers and the Acquired Immunodeficiency Syndrome (AIDS): Demographic, Drug Use, and Needle-Sharing Patterns. JAMA Internal Medicine 1985, 145: 1413-1417. DOI: 10.1001/archinte.1985.00360080085012.Peer-Reviewed Original ResearchAcquired Immunodeficiency SyndromeDrug abuser patientsIntravenous drug abusersDrug abusersImmunodeficiency syndromeNeedle sharingHomosexual menSpread of AIDSPutative AIDS agentPercent of patientsBlood-borne routeDrug use patternsDrug use practicesARC patientsSexual habitsDrug usePatientsShooting galleriesAIDS agentsAIDS transmissionMale homosexualsDemographic characteristicsAbusersSyndromeHigh rateIntravenous drug abusers and the acquired immunodeficiency syndrome (AIDS). Demographic, drug use, and needle-sharing patterns.
Friedland G, Harris C, Butkus-Small C, Shine D, Moll B, Darrow W, Klein R. Intravenous drug abusers and the acquired immunodeficiency syndrome (AIDS). Demographic, drug use, and needle-sharing patterns. JAMA Internal Medicine 1985, 145: 1413-7. PMID: 3875327, DOI: 10.1001/archinte.145.8.1413.Peer-Reviewed Original ResearchConceptsDrug abuser patientsIntravenous drug abusersDrug abusersImmunodeficiency syndromeNeedle sharingHomosexual menPutative AIDS agentPercent of patientsEvidence of AIDSBlood-borne routeDrug use patternsDrug use practicesARC patientsSexual habitsDrug usePatientsShooting galleriesSpread of AIDSAIDS agentsAIDSAIDS transmissionMale homosexualsDemographic characteristicsAbusersSyndromeThe Treatment of Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome
Small C, Harris C, Friedland G, Klein R. The Treatment of Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome. JAMA Internal Medicine 1985, 145: 837-840. PMID: 3873229, DOI: 10.1001/archinte.1985.00360050081015.Peer-Reviewed Original ResearchConceptsPneumocystis carinii pneumoniaImmunodeficiency syndromeAdverse reactionsCarinii pneumoniaEpisodes of PCPRecurrent Pneumocystis carinii pneumoniaAcquired Immunodeficiency SyndromeUnresponsive infectionsLate recurrenceTrimethoprim-sulfamethoxazolePatientsAdditional episodesSyndromeTherapySecond weekPneumoniaEpisodesImmediate reactionsFailure rateLeukopeniaRashFeverRecurrenceHepatotoxicityInfection
1984
Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency Syndrome
Klein R, Harris C, Small C, Moll B, Lesser M, Friedland G. Oral Candidiasis in High-Risk Patients as the Initial Manifestation of the Acquired Immunodeficiency Syndrome. New England Journal Of Medicine 1984, 311: 354-358. PMID: 6738653, DOI: 10.1056/nejm198408093110602.Peer-Reviewed Original ResearchConceptsT4/T8 ratioOral candidiasisT8 ratioImmunodeficiency syndromeOpportunistic infectionsHigh-risk patientsMajor opportunistic infectionIntravenous drug abusersAcquired Immunodeficiency SyndromeSerious opportunistic infectionsGeneralized lymphadenopathyInitial manifestationSimilar patientsKaposi's sarcomaHigh riskPatientsHealthy adultsCandidiasisLymphadenopathyBisexual menAIDSSarcomaSyndromeInfectionMonths
1983
Acquired Immunodeficiency Syndrome Ophthalmic Manifestations in Ambulatory Patients
Rosenberg P, Uliss A, Friedland G, Harris C, Small C, Klein R. Acquired Immunodeficiency Syndrome Ophthalmic Manifestations in Ambulatory Patients. Ophthalmology 1983, 90: 874-878. PMID: 6314220, DOI: 10.1016/s0161-6420(83)80010-4.Peer-Reviewed Original ResearchConceptsAmbulatory patientsIntravenous drug abuseCotton wool spotsEpidemiology of AIDSCytomegalovirus retinitisOcular findingsOcular involvementOphthalmic manifestationsImmunodeficiency syndromePatientsMajor manifestationsDrug abuseManifestationsRetinitisSyndromeOphthalmologistsEpidemiologyAIDSFindingsImmunodeficiency in Female Sexual Partners of Men with the Acquired Immunodeficiency Syndrome
Harris C, Small C, Klein R, Friedland G, Moll B, Emeson E, Spigland I, Steigbigel N. Immunodeficiency in Female Sexual Partners of Men with the Acquired Immunodeficiency Syndrome. New England Journal Of Medicine 1983, 308: 1181-1184. PMID: 6221192, DOI: 10.1056/nejm198305193082001.Peer-Reviewed Original ResearchConceptsFemale sexual partnersMale patientsImmunodeficiency syndromeSexual partnersProdrome of AIDSSuppressor T cellsAcquired Immunodeficiency SyndromeImmunologic abnormalitiesProdromal illnessBiologic agentsT cellsDrug abusersHealthy adultsSyndromeCurrent outbreakDecreased ratioWomenPatientsHeterosexual menIllnessAbnormalitiesAIDSMenLymphadenopathyLymphopenia