2010
Infectious Disease Comorbidities Adversely Affecting Substance Users With HIV: Hepatitis C and Tuberculosis
Friedland G. Infectious Disease Comorbidities Adversely Affecting Substance Users With HIV: Hepatitis C and Tuberculosis. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 55: s37-s42. PMID: 21045598, PMCID: PMC4505738, DOI: 10.1097/qai.0b013e3181f9c0b6.Peer-Reviewed Original ResearchConceptsHepatitis CDrug interactionsDrug usersDrug useActive screening programsSpecial clinical challengeIsoniazid preventive therapySubstance abusersInjection drug usePharmacodynamic drug interactionsDrug-resistant organismsTreatment of tuberculosisInfectious disease comorbiditiesHIV/AIDSPreventive therapyTreatment initiationComorbid conditionsMedication adherenceHIV pandemicScreening programClinical challengeClinician expertiseTherapeutic successClinical consequencesInfection control
2008
Pharmacokinetic drug interactions between drugs of abuse and antiretroviral medications: implications and management for clinical practice
Bruce RD, Altice FL, Friedland GH. Pharmacokinetic drug interactions between drugs of abuse and antiretroviral medications: implications and management for clinical practice. Expert Review Of Clinical Pharmacology 2008, 1: 115-127. PMID: 24410515, DOI: 10.1586/17512433.1.1.115.Peer-Reviewed Original ResearchPharmacokinetic drug interactionsDrugs of abuseDrug interactionsAntiretroviral therapyHIV treatmentActive illicit drug useClinical implicationsImportant pharmacokinetic drug interactionsClinical case seriesImportant clinical consequencesIllicit drug useHIV/AIDSMetabolism of drugsPharmacokinetic interaction studyAntiretroviral medicationsCase seriesTreatable diseaseClinical consequencesClinical practiceDrug useMedical consequencesSubstance abuseTherapyDrugsAbuse
1995
Injection Drug Use and Human Immunodeficiency Virus Infection
Alcabes P, Friedland G. Injection Drug Use and Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 1995, 20: 1467-1479. PMID: 7548494, DOI: 10.1093/clinids/20.6.1467.Peer-Reviewed Original ResearchConceptsSurveillance case definitionHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionDrug usersCase definitionInjection drugsVirus infectionPrevention (CDC) surveillance case definitionDiagnosis of AIDSInjection drug useInjection drug usersHigh mortality rateHIV diseaseHIV infectionDrug injectorsMortality rateDrug useNew casesNatural historyDisease controlAIDSDiagnostic facilitiesAIDS epidemicInitial epidemicLack of advocates
1991
Human T Lymphotropic Virus Type II (HTLV-II) Infection in a Cohort of New York Intravenous Drug Users: An Old Infection?
Khabbaz R, Hartel D, Lairmore M, Horsburgh C, Schoenbaum E, Roberts B, Hartley T, Friedland G. Human T Lymphotropic Virus Type II (HTLV-II) Infection in a Cohort of New York Intravenous Drug Users: An Old Infection? The Journal Of Infectious Diseases 1991, 163: 252-256. PMID: 1988509, DOI: 10.1093/infdis/163.2.252.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHuman T-lymphotropic virus type II (HTLV-II) infectionHTLV-II infectionType II infectionPolymerase chain reactionRisk factorsHTLV-IIDrug usersHuman immunodeficiency virus (HIV) infectionHIV infection statusImmunodeficiency virus infectionIntravenous drug useMethadone maintenance programTransfusion historyNeedle sharingVirus infectionSerologic resultsSex partnersDrug useShooting galleriesEndemic infectionInfectionOlder ageInfection statusOld infectionDemographic characteristics, drug use, and sexual behavior of i.v. drug user with AIDS in Bronx, New York.
Schrager L, Friedland G, Feiner C, Kahl P. Demographic characteristics, drug use, and sexual behavior of i.v. drug user with AIDS in Bronx, New York. Public Health Reports 1991, 106: 78-84. PMID: 1899944, PMCID: PMC1580205.Peer-Reviewed Original ResearchConceptsDrug usersDemographic characteristicsDrug useHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionIntravenous drug usersMontefiore Medical CenterMethadone maintenance programSharing of needlesInjection of drugsSexual behaviorDrug use behaviorsDrug use practicesHIV infectionImmunodeficiency syndromeVirus infectionMedical CenterEpidemiologic informationShooting galleriesCocaine useAIDSInjection episodesSexual practicesEarly ageInfectionSurvival differences in patients with AIDS.
Friedland G, Saltzman B, Vileno J, Freeman K, Schrager L, Klein R. Survival differences in patients with AIDS. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1991, 4: 144-53. PMID: 1987352.Peer-Reviewed Original ResearchConceptsPneumocystis carinii pneumoniaFavorable survivalCarinii pneumoniaMale sexYounger ageRisk behaviorsInitial AIDS diagnosisSingle medical centerIntravenous drug usePoint of diagnosisInitial AIDSMedian survivalAIDS diagnosisBlack raceSurvival differencesKaposi's sarcomaMedical CenterClinical carePatientsDrug useAIDSSurvivalDiagnosisPowerful predictorMonths
1990
A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients
McKegney F, O'Dowd M, Feiner C, Selwyn P, Drucker E, Friedland G. A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients. AIDS 1990, 4: 565-570. PMID: 2386618, DOI: 10.1097/00002030-199006000-00011.Peer-Reviewed Original ResearchConceptsPsychological Screening TestMethadone clinic patientsMethadone-maintained populationsEvidence of HIVMethadone-maintained patientsDigit spanProspective longitudinal studyPsychosocial functioningNeuropsychologic functionRace/ethnicityPsychosocial assessmentCognitive impairmentHIV antibodiesHIV infectionLongitudinal studyUnivariate analysisMean intervalProspective comparisonSerological testingSerological statusPhysical symptomsDrug useBaseline testingScreening testSeropositives
1989
Risk Factors for Human Immunodeficiency Virus Infection in Intravenous Drug Users
Schoenbaum E, Hartel D, Selwyn P, Klein R, Davenny K, Rogers M, Feiner C, Friedland G. Risk Factors for Human Immunodeficiency Virus Infection in Intravenous Drug Users. New England Journal Of Medicine 1989, 321: 874-879. PMID: 2770823, DOI: 10.1056/nejm198909283211306.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionIntravenous drug usersPercentage of injectionsRisk factorsHIV antibodiesDrug usersIntravenous drugsVirus infectionSex partnersSeroprevalence of HIVIndependent risk factorOnly risk factorMethadone treatment programsNumber of injectionsNon-Hispanic whitesHeterosexual sex partnersHIV infectionLast injectionUsed needlesHigh seroprevalenceDrug useShooting galleriesHIVInfection
1988
Increased risk of bacterial pneumonia in HIV-infected intravenous drug users without AIDS
Selwyn P, Feingold A, Hartel D, Schoenbaum E, Alderman M, Klein R, Friedland G. Increased risk of bacterial pneumonia in HIV-infected intravenous drug users without AIDS. AIDS 1988, 2: 267-272. PMID: 3140832, DOI: 10.1097/00002030-198808000-00005.Peer-Reviewed Original ResearchConceptsIntravenous drug usersIntravenous drug useBacterial pneumoniaHIV infectionDrug usersDrug useActive intravenous drug useCommunity-acquired bacterial pneumoniaCumulative yearly incidenceMethadone maintenance programSeronegative subjectsSeropositive patientsSeropositive subjectsStudy entryOpportunistic infectionsYearly incidencePneumoniaHemophilus influenzaeStreptococcus pneumoniaeSeropositivesHIVAIDSInfectionStudy periodIncidence
1987
A Prospective Longitudinal Study of Neuropsychological and Psychosocial Factors in Asymptomatic Individuals at Risk for Htlv-III/Lav Infection in a Methadone Program: Preliminary Findings
Silberstein C, McKegney F, O'dowd M, Selwyn P, Schoenbaum E, Drucker E, Feiner C, Cox C, Friedland G. A Prospective Longitudinal Study of Neuropsychological and Psychosocial Factors in Asymptomatic Individuals at Risk for Htlv-III/Lav Infection in a Methadone Program: Preliminary Findings. International Journal Of Neuroscience 1987, 32: 669-676. PMID: 3596916, DOI: 10.3109/00207458709043321.Peer-Reviewed Original ResearchConceptsProspective longitudinal studyWAIS similaritiesAssociative learning testHTLV-III/LAV infectionDigit Span ForwardLongitudinal studyImpaired neuropsychological functionLearning TestNeuropsychological functionPsychosocial measuresTest performanceFinger tappingPsychosocial factorsPsychological stressCognitive impairmentPreliminary findingsHTLV-III/LAVIntravenous drug abusersHigh-risk populationAbsence of AIDSDrug useDrug abusersAsymptomatic individualsMethadone programsUnivariate analysis
1985
Intravenous Drug Abusers and the Acquired Immunodeficiency Syndrome (AIDS): Demographic, Drug Use, and Needle-Sharing Patterns
Friedland G, Harris C, Butkus-Small C, Shine D, Moll B, Darrow W, Klein R. Intravenous Drug Abusers and the Acquired Immunodeficiency Syndrome (AIDS): Demographic, Drug Use, and Needle-Sharing Patterns. JAMA Internal Medicine 1985, 145: 1413-1417. DOI: 10.1001/archinte.1985.00360080085012.Peer-Reviewed Original ResearchAcquired Immunodeficiency SyndromeDrug abuser patientsIntravenous drug abusersDrug abusersImmunodeficiency syndromeNeedle sharingHomosexual menSpread of AIDSPutative AIDS agentPercent of patientsBlood-borne routeDrug use patternsDrug use practicesARC patientsSexual habitsDrug usePatientsShooting galleriesAIDS agentsAIDS transmissionMale homosexualsDemographic characteristicsAbusersSyndromeHigh rateIntravenous drug abusers and the acquired immunodeficiency syndrome (AIDS). Demographic, drug use, and needle-sharing patterns.
Friedland G, Harris C, Butkus-Small C, Shine D, Moll B, Darrow W, Klein R. Intravenous drug abusers and the acquired immunodeficiency syndrome (AIDS). Demographic, drug use, and needle-sharing patterns. JAMA Internal Medicine 1985, 145: 1413-7. PMID: 3875327, DOI: 10.1001/archinte.145.8.1413.Peer-Reviewed Original ResearchConceptsDrug abuser patientsIntravenous drug abusersDrug abusersImmunodeficiency syndromeNeedle sharingHomosexual menPutative AIDS agentPercent of patientsEvidence of AIDSBlood-borne routeDrug use patternsDrug use practicesARC patientsSexual habitsDrug usePatientsShooting galleriesSpread of AIDSAIDS agentsAIDSAIDS transmissionMale homosexualsDemographic characteristicsAbusersSyndrome