1992
High Risk of Active Tuberculosis in HIV-Infected Drug Users With Cutaneous Anergy
Selwyn P, Sckell B, Alcabes P, Friedland G, Klein R, Schoenbaum E. High Risk of Active Tuberculosis in HIV-Infected Drug Users With Cutaneous Anergy. JAMA 1992, 268: 504-509. PMID: 1619742, DOI: 10.1001/jama.1992.03490040080029.Peer-Reviewed Original ResearchConceptsHIV serological statusAnergic subjectsActive tuberculosisTuberculin reactorsCutaneous anergyDrug injectorsIsoniazid chemoprophylaxisIsoniazid prophylaxisHIV infectionTuberculosis incidenceTuberculin testingSerological statusHigh riskDelayed-type hypersensitivity skin testingDelayed-type hypersensitivity testingPositive tuberculin test resultsStudy periodAdvanced HIV diseaseHIV disease statusMonths of prophylaxisT lymphocyte levelsHypersensitivity skin testingProspective observational studyTuberculosis incidence rateMycobacterium tuberculosis infection
1983
Community-acquired opportunistic infections and defective cellular immunity in heterosexual drug abusers and homosexual men
Small C, Klein R, Friedland G, Moll B, Emeson E, Spigland I. Community-acquired opportunistic infections and defective cellular immunity in heterosexual drug abusers and homosexual men. The American Journal Of Medicine 1983, 74: 433-441. PMID: 6219579, DOI: 10.1016/0002-9343(83)90970-1.Peer-Reviewed Original ResearchConceptsOpportunistic infectionsSevere opportunistic infectionsHomosexual menDrug abusersOral thrushCellular immunityT helper/inducer cellsT suppressor/cytotoxic cellsHelper/inducer cellsSuppressor/cytotoxic cellsHealthy young patientsSyndrome of immunodeficiencyPneumocystis carinii pneumoniaMycobacterium intracellulare infectionDefective cellular immunityWhite homosexual menCutaneous anergyCandida esophagitisYounger patientsNonspecific findingsClinical presentationCarinii pneumoniaCytotoxic cellsInducer cellsIntracellulare infection
1982
Inverted ratio of inducer to suppressor T-lymphocyte subsets in drug abusers with opportunistic infections
Moll B, Emeson E, Small C, Friedland G, Klein R, Spigland I. Inverted ratio of inducer to suppressor T-lymphocyte subsets in drug abusers with opportunistic infections. Clinical Immunology 1982, 25: 417-423. PMID: 6218947, DOI: 10.1016/0090-1229(82)90206-9.Peer-Reviewed Original ResearchConceptsT lymphocyte subsetsOpportunistic infectionsOnly opportunistic infectionPercentage of T8Pneumocystis carinii pneumoniaPercentage of T4Ratio of inducerCutaneous anergyCarinii pneumoniaImmune statusPeripheral bloodOral candidiasisProliferative responsePatientsDrug abusersDrug abuseMarked reductionInfectionP. cariniiLymphocytesFurther evidencePneumoniaAnergyHistoplasmosisCandidiasis