2020
P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice
Spronck B, Latorre M, Mehta S, Caulk A, Ramachandra A, Murtada S, Rojas A, He C, Jiang B, Wang M, Bersi M, Tellides G, Humphrey J. P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice. Artery Research 2020, 26: s81-s82. DOI: 10.2991/artres.k.201209.068.Peer-Reviewed Original Research
2018
Central artery stiffness and thoracic aortopathy
Humphrey J, Tellides G. Central artery stiffness and thoracic aortopathy. AJP Heart And Circulatory Physiology 2018, 316: h169-h182. PMID: 30412443, PMCID: PMC6880196, DOI: 10.1152/ajpheart.00205.2018.Peer-Reviewed Original ResearchConceptsCentral arteriesEnd-organ diseaseProximal thoracic aortaCentral artery stiffnessPrimary risk factorUncontrolled hypertensionAntihypertensive medicationsNonsurgical treatmentSignificant morbidityArtery stiffnessAortic aneurysmPulse pressureRisk factorsThoracic aortaDisease progressionStrenuous exerciseMouse modelMarfan syndromeWeight liftingGlobal hemodynamicsDysfunctional mechanosensingLethal conditionAortaGenetic mutationsArtery