2021
Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling
Kawamura Y, Murtada S, Gao F, Liu X, Tellides G, Humphrey J. Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling. Journal Of The Mechanical Behavior Of Biomedical Materials 2021, 116: 104264. PMID: 33508556, PMCID: PMC7959590, DOI: 10.1016/j.jmbbm.2020.104264.Peer-Reviewed Original ResearchConceptsAortic dissectionMouse modelAortic wallCompensatory changesThoracic aortic dissectionMuscle-specific disruptionSmooth muscle cellsLoss of TGFβMedial integrityAortic ruptureClinical presentationMuscle cellsQuantitative histologyMatrix turnoverTGFβ receptorsDissectionWall stressTGFβType IIndividual subjectsSpecific disruptionVivo valuesExaminationRupture
1999
Management of descending aortic dissection
Elefteriades J, Lovoulos C, Coady M, Tellides G, Kopf G, Rizzo J. Management of descending aortic dissection. The Annals Of Thoracic Surgery 1999, 67: 2002-2005. PMID: 10391358, DOI: 10.1016/s0003-4975(99)00428-2.Peer-Reviewed Original ResearchConceptsThoracic aortic diseaseAortic replacementAortic dissectionAortic diseaseVascular occlusionCategory of patientsEarly hospital courseTime of dissectionParaplegia rateAcute dissectionHospital coursePostoperative deathsAcute expansionPatient demographicsConsecutive patientsMultiple complicationsBenign courseMedical managementSpecific complicationsSurgical interventionClinical recordsAortic aneurysmComplicated dissectionFenestration procedureTherapy varies