1998
The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes
Ragoczy T, Heston L, Miller G. The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes. Journal Of Virology 1998, 72: 7978-7984. PMID: 9733836, PMCID: PMC110133, DOI: 10.1128/jvi.72.10.7978-7984.1998.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesBase SequenceCell LineChloramphenicol O-AcetyltransferaseDNA PrimersDNA ReplicationDNA-Binding ProteinsGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmediate-Early ProteinsPromoter Regions, GeneticTrans-ActivatorsTranscription FactorsViral ProteinsVirus LatencyConceptsEpstein-Barr virusLytic cycle genesB lymphocytesEpstein–Barr virus Rta proteinEpithelial cellsLytic cycleDisruption of latencyViral lytic cycleB cell linesEBV entryImmediate early viral genesBZLF1LymphocytesCycle genesExpression of RTARTA functionBRLF1Rta proteinDownstream targetsViral genesViral DNA replicationExpressionCells
1987
Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus
Rowe D, Farrell P, Miller G. Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus. Virology 1987, 156: 153-162. PMID: 3027963, DOI: 10.1016/0042-6822(87)90446-6.Peer-Reviewed Original ResearchConceptsEBNA seraAntigen complexX50-7Immortalization of lymphocytesEpstein-Barr virusEBNA INovel nuclear antigenIV groupNew antigensNuclear antigenLymphocytesCell clonesWestern immunoblottingSerumCell linesEBVAntigenMolecular weight proteinsHuman serumHigh molecular weight proteinsRajiVirusViral genomeGroupWeight proteins
1985
Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1.
Rowe D, Heston L, Metlay J, Miller G. Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 7429-7433. PMID: 2997790, PMCID: PMC391358, DOI: 10.1073/pnas.82.21.7429.Peer-Reviewed Original ResearchConceptsChronic active EBV infectionActive EBV infectionEpstein-Barr virusJijoye strainEBV infectionEBV DNACertain patientsP3HR-1Human antiseraVirus strainsNuclear antigenHr-1JijoyeVirus deletion mutantsLtk- cellsMouse Ltk- cellsImmortalization processPatientsGene transferNeoantigensLymphocytesInfectionAntigen
1982
New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma
Heston L, Rabson M, Brown N, Miller G. New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma. Nature 1982, 295: 160-163. PMID: 6276755, DOI: 10.1038/295160a0.Peer-Reviewed Original Research
1981
Copy number and location of Epstein-Barr viral genomes in neonatal human lymphocytes transformed after separation by size and treatment with mitogens
Anvret M, Miller G. Copy number and location of Epstein-Barr viral genomes in neonatal human lymphocytes transformed after separation by size and treatment with mitogens. Virology 1981, 111: 47-55. PMID: 6263010, DOI: 10.1016/0042-6822(81)90652-8.Peer-Reviewed Original ResearchConceptsNeonatal human lymphocytesEBV DNACell linesStaphylococcus aureusEpstein-Barr viral genomeHuman lymphocytesEBV DNA copiesEpstein-Barr virusPurified B lymphocytesFresh umbilical cordsB95-8 strainFicoll-Hypaque gradientDifferent cell linesEB virusMedian numberUmbilical cordB lymphocytesViral infectionViral genomeLymphocytesLipopolysaccharideSmall cell fractionPhysiologic stateTime of exposureCell fractionEpstein-Barr Viral DNA: Infectivity for Human Placental Cells
Miller G, Grogan E, Heston L, Robinson J, Smith D. Epstein-Barr Viral DNA: Infectivity for Human Placental Cells. Science 1981, 212: 452-455. PMID: 6259735, DOI: 10.1126/science.6259735.Peer-Reviewed Original Research
1979
SITE OF EPSTEIN-BARR VIRUS REPLICATION IN THE OROPHARYNX
Morgan DG, Miller G, Niederman J, Smith HW, Dowaliby JM. SITE OF EPSTEIN-BARR VIRUS REPLICATION IN THE OROPHARYNX. The Lancet 1979, 314: 1154-1157. PMID: 91888, DOI: 10.1016/s0140-6736(79)92384-5.Peer-Reviewed Original ResearchConceptsInfectious Epstein-Barr virusEpstein-Barr virus replicationAcute infectious mononucleosisEpstein-Barr virusInfectious mononucleosisPatient's virusThroat washingsViral antigensEBV productionTonsillar lymphocytesInfectious virusVirus replicationParotid secretionPatientsCell-free formSalivary glandsOropharynxVirusSecretionCell-free materialSalivaMononucleosisCellsTonsillectomyLymphocytes
1977
Efficiency of transformation of lymphocytes by Epstein-Barr virus
Henderson E, Miller G, Robinson J, Heston L. Efficiency of transformation of lymphocytes by Epstein-Barr virus. Virology 1977, 76: 152-163. PMID: 189490, DOI: 10.1016/0042-6822(77)90292-6.Peer-Reviewed Original ResearchConceptsHuman umbilical cord leukocytesEpstein-Barr virusCord blood leukocytesBlood leukocytesMixed mononuclear cellsSusceptible cellsB95-8 strainUmbilical cord leukocytesSusceptibility of lymphocytesHuman placental cellsUmbilical cord cellsVirus-exposed cellsMultiplicity of infectionMononuclear cellsT lymphocytesMononuclear leukocytesCord cellsPlacental cellsAutochthonous lymphocytesViral factorsLymphocytesMarmoset bloodCellular DNA synthesisLeukocytesAdult humans
1975
Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference.
Miller G, Robinson J, Heston L, Lipman M. Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference. IARC Scientific Publications 1975, 395-408. PMID: 190145.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEarly antigenH virusInitiation of immortalizationAntibody-negative human serumPretreatment of lymphocytesNon-producer cell linesCell linesHuman umbilical cordHuman serumInfectious mononucleosisCarrier cell linesB95-8Umbilical cordBurkitt's lymphomaLymphocyte immortalizationDNA synthesisLaboratory strainsStimulation of DNAHuman lymphocytesLymphocytesBiological behaviorPrimary culturesAbortive infectionAntigen
1974
Differences Between Laboratory Strains of Epstein-Barr Virus Based on Immortalization, Abortive Infection, and Interference
Miller G, Robinson J, Heston L, Lipman M. Differences Between Laboratory Strains of Epstein-Barr Virus Based on Immortalization, Abortive Infection, and Interference. Proceedings Of The National Academy Of Sciences Of The United States Of America 1974, 71: 4006-4010. PMID: 4372601, PMCID: PMC434316, DOI: 10.1073/pnas.71.10.4006.Peer-Reviewed Original ResearchConceptsEB virusEarly antigenH virusInitiation of immortalizationAntibody-negative human serumEpstein-Barr virusPretreatment of lymphocytesCell linesHuman umbilical cordDNA synthesisHuman serumInfectious mononucleosisCarrier cell linesBiologic behaviorB95-8Umbilical cordBurkitt's lymphomaLymphocyte immortalizationNonproducer cell linesHuman lymphocytesLaboratory strainsLymphocytesBiologic activityPrimary culturesAbortive infection