2024
Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies
Farooq U, Dragoi G. Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies. Nature Communications 2024, 15: 8417. PMID: 39341810, PMCID: PMC11438871, DOI: 10.1038/s41467-024-52758-9.Peer-Reviewed Original ResearchPublisher Correction: Nested compressed co-representations of multiple sequential experiences during sleep
Liu K, Sibille J, Dragoi G. Publisher Correction: Nested compressed co-representations of multiple sequential experiences during sleep. Nature Neuroscience 2024, 27: 1860-1860. PMID: 39147942, DOI: 10.1038/s41593-024-01751-y.Peer-Reviewed Original ResearchNested compressed co-representations of multiple sequential experiences during sleep
Liu K, Sibille J, Dragoi G. Nested compressed co-representations of multiple sequential experiences during sleep. Nature Neuroscience 2024, 27: 1816-1828. PMID: 39030341, DOI: 10.1038/s41593-024-01703-6.Peer-Reviewed Original Research
2023
The generative grammar of the brain: a critique of internally generated representations
Dragoi G. The generative grammar of the brain: a critique of internally generated representations. Nature Reviews Neuroscience 2023, 25: 60-75. PMID: 38036709, DOI: 10.1038/s41583-023-00763-0.Peer-Reviewed Original ResearchConceptsImportant organizational principleGenerative grammarCognitive processesNeuropsychological perspectiveRapid encodingNeurobiological perspectiveMemory consolidationNew learningBrain functionNovel experienceSpecific experiencesOrganizational principlesCompetenceLearningNeuronal selectionHippocampal neural networkRepresentationGrammarNeural networkBrainMemoryExperienceNeurobiologyEncodingSyntax
2021
Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus
Liu K, Sibille J, Dragoi G. Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus. Neuron 2021, 109: 3688-3698.e6. PMID: 34506724, PMCID: PMC8602755, DOI: 10.1016/j.neuron.2021.08.013.Peer-Reviewed Original Research
2020
The Ontogeny of Hippocampus-Dependent Memories
Donato F, Alberini CM, Amso D, Dragoi G, Dranovsky A, Newcombe NS. The Ontogeny of Hippocampus-Dependent Memories. Journal Of Neuroscience 2020, 41: 920-926. PMID: 33328296, PMCID: PMC7880290, DOI: 10.1523/jneurosci.1651-20.2020.Peer-Reviewed Original ResearchConceptsHippocampus-dependent memory systemHippocampus-dependent memoryMemory systemTypes of memoryMedial temporal lobeFormation of memoryMemory reliesMemory processesMemoryTemporal lobeInfant hippocampusBiological correlatesAdult systemActivity dynamicsHippocampusRecent evidenceLearningCorrelatesFirst yearAdultsAcquisitionInfancyLifeCircuitryPlace of acquisitionCell assemblies, sequences and temporal coding in the hippocampus
Dragoi G. Cell assemblies, sequences and temporal coding in the hippocampus. Current Opinion In Neurobiology 2020, 64: 111-118. PMID: 32375084, PMCID: PMC7606333, DOI: 10.1016/j.conb.2020.03.003.Peer-Reviewed Original ResearchA consensus statement: defining terms for reactivation analysis
Genzel L, Dragoi G, Frank L, Ganguly K, de la Prida L, Pfeiffer B, Robertson E. A consensus statement: defining terms for reactivation analysis. Philosophical Transactions Of The Royal Society B Biological Sciences 2020, 375: 20200001. PMID: 32248790, PMCID: PMC7209922, DOI: 10.1098/rstb.2020.0001.Peer-Reviewed Original Research
2019
Strengthened Temporal Coordination within Pre-existing Sequential Cell Assemblies Supports Trajectory Replay
Farooq U, Sibille J, Liu K, Dragoi G. Strengthened Temporal Coordination within Pre-existing Sequential Cell Assemblies Supports Trajectory Replay. Neuron 2019, 103: 719-733.e7. PMID: 31253469, PMCID: PMC7197404, DOI: 10.1016/j.neuron.2019.05.040.Peer-Reviewed Original ResearchEmergence of preconfigured and plastic time-compressed sequences in early postnatal development
Farooq U, Dragoi G. Emergence of preconfigured and plastic time-compressed sequences in early postnatal development. Science 2019, 363: 168-173. PMID: 30630930, PMCID: PMC6794005, DOI: 10.1126/science.aav0502.Peer-Reviewed Original ResearchConceptsCritical cognitive functionsEpisodic memory formationHippocampal neuronal ensemblesMemory episodesCognitive functionMemory formationPostnatal week 4Postnatal week 3Neuronal ensemblesEarly postnatal developmentElectrophysiological activityNaïve ratsWeek 4Hippocampal neuronsPostnatal developmentWeek 3Eye openingFirst dayEncodingSequential patternsLinear environmentSleepReplay
2018
Preconfigured patterns are the primary driver of offline multi‐neuronal sequence replay
Liu K, Sibille J, Dragoi G. Preconfigured patterns are the primary driver of offline multi‐neuronal sequence replay. Hippocampus 2018, 29: 275-283. PMID: 30260526, PMCID: PMC6793999, DOI: 10.1002/hipo.23034.Peer-Reviewed Original ResearchGenerative Predictive Codes by Multiplexed Hippocampal Neuronal Tuplets
Liu K, Sibille J, Dragoi G. Generative Predictive Codes by Multiplexed Hippocampal Neuronal Tuplets. Neuron 2018, 99: 1329-1341.e6. PMID: 30146305, DOI: 10.1016/j.neuron.2018.07.047.Peer-Reviewed Original Research
2017
Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective
Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD. Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Biological Psychiatry 2017, 81: 874-885. PMID: 28434616, PMCID: PMC5407407, DOI: 10.1016/j.biopsych.2017.01.004.Peer-Reviewed Original ResearchConceptsNeural activityNeural ensemblesComputational neuroscience perspectiveHigher cognitive functionsNeuroscience perspectiveDevelopmental perspectiveDevelopmental correlatesCognitive functionNegative functional consequencesCortical networksComputational neuroscienceNeural codeCortical activityCognitive impairmentNeural dysfunctionAspartate glutamate receptor antagonistTemporal tuningSpatial tuningGlutamate receptor antagonistsPathophysiology of schizophreniaNeural network functionSchizophreniaPsychiatric disordersBalance of excitationInput-output curves
2014
Selection of preconfigured cell assemblies for representation of novel spatial experiences.
Dragoi G, Tonegawa S. Selection of preconfigured cell assemblies for representation of novel spatial experiences. Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences 2014, 369: 20120522. PMID: 24366134, PMCID: PMC3866444, DOI: 10.1098/rstb.2012.0522.Peer-Reviewed Original Research
2013
Development of schemas revealed by prior experience and NMDA receptor knock-out.
Dragoi G, Tonegawa S. Development of schemas revealed by prior experience and NMDA receptor knock-out. ELife 2013, 2: e01326. PMID: 24327561, PMCID: PMC3851680, DOI: 10.7554/eLife.01326.Peer-Reviewed Original ResearchDistinct preplay of multiple novel spatial experiences in the rat.
Dragoi G, Tonegawa S. Distinct preplay of multiple novel spatial experiences in the rat. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 9100-5. PMID: 23671088, PMCID: PMC3670374, DOI: 10.1073/pnas.1306031110.Peer-Reviewed Original ResearchInternal operations in the hippocampus: single cell and ensemble temporal coding.
Dragoi G. Internal operations in the hippocampus: single cell and ensemble temporal coding. Frontiers In Systems Neuroscience 2013, 7: 46. PMID: 24009564, PMCID: PMC3756298, DOI: 10.3389/fnsys.2013.00046.Peer-Reviewed Original Research
2011
Preplay of future place cell sequences by hippocampal cellular assemblies.
Dragoi G, Tonegawa S. Preplay of future place cell sequences by hippocampal cellular assemblies. Nature 2011, 469: 397-401. PMID: 21179088, PMCID: PMC3104398, DOI: 10.1038/nature09633.Peer-Reviewed Original Research
2006
Temporal encoding of place sequences by hippocampal cell assemblies.
Dragoi G, Buzsáki G. Temporal encoding of place sequences by hippocampal cell assemblies. Neuron 2006, 50: 145-57. PMID: 16600862, DOI: 10.1016/j.neuron.2006.02.023.Peer-Reviewed Original Research
2003
Place representation within hippocampal networks is modified by long-term potentiation.
Dragoi G, Harris KD, Buzsáki G. Place representation within hippocampal networks is modified by long-term potentiation. Neuron 2003, 39: 843-53. PMID: 12948450, DOI: 10.1016/s0896-6273(03)00465-3.Peer-Reviewed Original Research