2008
The potential role for emergence in autism
Anderson GM. The potential role for emergence in autism. Autism Research 2008, 1: 18-30. PMID: 19360647, DOI: 10.1002/aur.2.Peer-Reviewed Original Research
2006
Placental Trophoblast Inclusions in Autism Spectrum Disorder
Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental Trophoblast Inclusions in Autism Spectrum Disorder. Biological Psychiatry 2006, 61: 487-491. PMID: 16806106, DOI: 10.1016/j.biopsych.2006.03.068.Peer-Reviewed Original ResearchEffects of Short- and Long-Term Risperidone Treatment on Prolactin Levels in Children with Autism
Anderson GM, Scahill L, McCracken JT, McDougle CJ, Aman MG, Tierney E, Arnold LE, Martin A, Katsovich L, Posey DJ, Shah B, Vitiello B. Effects of Short- and Long-Term Risperidone Treatment on Prolactin Levels in Children with Autism. Biological Psychiatry 2006, 61: 545-550. PMID: 16730335, DOI: 10.1016/j.biopsych.2006.02.032.Peer-Reviewed Original ResearchConceptsRisperidone-induced increasesLong-term risperidone treatmentProlactin levelsRisperidone treatmentSerum prolactinOpen-label followWeeks of risperidoneBaseline prolactin levelsEffects of ShortPlacebo groupProlactin elevationReceptor polymorphismsWeek 8Baseline levelsMean increaseProlactinRisperidoneSerum samplesAdverse effectsPlaceboChildrenTreatmentMonthsDRD2 allelesAdolescents
2005
Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder
Tordjman S, Anderson GM, Pichard N, Charbuy H, Touitou Y. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biological Psychiatry 2005, 57: 134-138. PMID: 15652871, DOI: 10.1016/j.biopsych.2004.11.003.Peer-Reviewed Original ResearchConceptsAutistic disorderNocturnal urinary excretionPineal gland hormoneLow melatonin productionNormal control individualsMelatonin physiologyGroup of childrenUrinary excretionMelatonin administrationTanner stageSleep problemsNormal controlsReported alterationNocturnal excretionControl individualsExcretion rateDisordersGland hormoneMelatoninMelatonin productionAutistic impairmentsExcretionCircadian rhythmBehavioral expressionVerbal communication
2002
Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia
Anderson G, Gutknecht L, Cohen DJ, Brailly-Tabard S, Cohen JH, Ferrari P, Roubertoux PL, Tordjman S. Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry 2002, 7: 831-836. PMID: 12232775, DOI: 10.1038/sj.mp.4001099.Peer-Reviewed Original ResearchAdolescentAutistic DisorderBlood PlateletsCarrier ProteinsChildCitalopramFemaleGenetic VariationGenotypeHumansLinear ModelsMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPromoter Regions, GeneticSelective Serotonin Reuptake InhibitorsSerotoninSerotonin Plasma Membrane Transport Proteins
2000
Adrenomedullary Function During Cognitive Testing in Attention-Deficit/Hyperactivity Disorder
ANDERSON G, DOVER M, YANG B, HOLAHAN J, SHAYWITZ S, MARCHIONE K, HALL L, FLETCHER J, SHAYWITZ B. Adrenomedullary Function During Cognitive Testing in Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 635-643. PMID: 10802982, DOI: 10.1097/00004583-200005000-00018.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderEPI excretionHyperactivity disorderCognitive testingOppositional defiant/conduct disorderCognitive test batteryADHD inattentive subtypeTeacher-rated behaviorDiagnostic group differencesCognition-enhancing effectsInattentive behaviorCognitive challengesLearning disorderInattention factorTest batteryConduct disorderCorrelational analysisGroup differencesClassroom performanceContrast groupSympathoadrenomedullary functionDisordersBoysIndividualsFunctioningPharmacogenetics: Promise and Potential in Child and Adolescent Psychiatry
Anderson G, Cook E. Pharmacogenetics: Promise and Potential in Child and Adolescent Psychiatry. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 23-42. PMID: 10674189, DOI: 10.1016/s1056-4993(18)30134-2.Peer-Reviewed Original Research
1998
Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors
Pfeffer C, McBride P, Anderson G, Kakuma T, Fensterheim L, Khait V. Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors. Biological Psychiatry 1998, 44: 568-577. PMID: 9787881, DOI: 10.1016/s0006-3223(98)00020-1.Peer-Reviewed Original ResearchConceptsPrepubertal psychiatric inpatientsBlood tryptophanRisk factorsSerotonin contentSuicidal behaviorMood disordersNormal controlsInpatient childrenSuicidal ideationSerotonin-amplified platelet aggregationPsychiatric inpatientsSuicide attemptsPlatelet serotonin contentEthnic differencesRecent suicide attemptSerotonin measuresPrepubertal controlsPlatelet serotoninPrepubertal childrenInpatientsPlatelet aggregationNormal childrenWhole bloodChildrenDisordersEffects of Diagnosis, Race, and Puberty on Platelet Serotonin Levels in Autism and Mental Retardation
MCBRIDE P, ANDERSON G, HERTZIG M, SNOW M, THOMPSON S, KHAIT V, SHAPIRO T, COHEN D. Effects of Diagnosis, Race, and Puberty on Platelet Serotonin Levels in Autism and Mental Retardation. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 767-776. PMID: 9666633, DOI: 10.1097/00004583-199807000-00017.Peer-Reviewed Original Research
1997
Plasma β‐Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism
Tordjman S, McBride P, Hertzig M, Snow M, Anderson G, Hall L, Thompson S, Ferrari P, Cohen D. Plasma β‐Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism. Journal Of Child Psychology And Psychiatry 1997, 38: 705-715. PMID: 9315980, DOI: 10.1111/j.1469-7610.1997.tb01697.x.Peer-Reviewed Original ResearchConceptsAdrenocorticotropin hormoneBeta-endorphinPlasma levelsHigher plasma levelsPlasma β-endorphinNormal control individualsAcute stress responseΒ-endorphinNormal controlsControl individualsAcute stressorChronic hyperarousalStress response systemSevere autismCortisolAutistic groupHormoneIndividualsGroupHighest meanAutistic individualsLevelsStress responseRisperidone Treatment of Children and Adolescents With Pervasive Developmental Disorders: A Prospective, Open-Label Study
MCDOUGLE C, HOLMES J, BRONSON M, ANDERSON G, VOLKMAR F, PRICE L, COHEN D. Risperidone Treatment of Children and Adolescents With Pervasive Developmental Disorders: A Prospective, Open-Label Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 1997, 36: 685-693. PMID: 9136504, DOI: 10.1097/00004583-199705000-00020.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderDevelopmental disordersRisperidone treatmentClinical Global Impression ScaleOpen-label studyOpen-label trialPlacebo-controlled studyCommon side effectsEfficacy of risperidoneShort-term safetyGlobal Impression ScaleGlobal improvement itemBehavioral ratingsChildhood disintegrative disorderSocial relatednessTreatment of childrenAsperger's disorderRepetitive behaviorsAutistic disorderBehavioral symptomsBaseline visitMean ageImpression ScaleAdolescentsOptimal dosePathogenesis of Tourette's Syndrome
Leckman J, Peterson B, Anderson G, Arnsten A, Pauls D, Cohen D. Pathogenesis of Tourette's Syndrome. Journal Of Child Psychology And Psychiatry 1997, 38: 119-142. PMID: 9232461, DOI: 10.1111/j.1469-7610.1997.tb01508.x.Peer-Reviewed Original Research
1996
Parental Presence during Induction of Anesthesia
Kain Z, Mayes L, Caramico L, Silver D, Spieker M, Nygren M, Anderson G, Rimar S. Parental Presence during Induction of Anesthesia. Anesthesiology 1996, 84: 1060-1067. PMID: 8623999, DOI: 10.1097/00000542-199605000-00007.Peer-Reviewed Original ResearchConceptsInduction of anesthesiaSerum cortisol concentrationsLow baseline levelsParental presencePhysiologic measuresBaseline levelsCortisol concentrationsPreoperative behavioral interventionsMultivariate linear regression analysisOutpatient surgeryIntervention groupLinear regression analysisControl groupParent-absent groupBaseline temperamentAnesthesiaBehavioral interventionsChild's ageSignificant differencesChildrenRegression analysisInterventionLow trait anxietyTrait anxietyAnxiety
1995
Plasma androgens in autism
Tordjman S, Anderson G, McBride P, Hertzig M, Snow M, Hall L, Ferrari P, Cohen D. Plasma androgens in autism. Journal Of Autism And Developmental Disorders 1995, 25: 295-304. PMID: 7559294, DOI: 10.1007/bf02179290.Peer-Reviewed Original ResearchConceptsCerebral palsyPlasma DHEA-S levelsNC individualsAdrenal androgen secretionDHEA-S levelsAdrenal androgen dehydroepiandrosterone sulfateBlood serotonin levelsNormal control subjectsWhole blood serotonin levelsEffect of pubertySignificant group differencesAndrogen secretionDehydroepiandrosterone sulfateControl subjectsPlasma levelsSerotonin levelsNC groupPlasma androgensPlasma testosteroneSignificant negative correlationTestosteroneImpaired subjectsWhole bloodMean levelsGroup differences
1994
Noradrenergic and adrenergic functioning in autism
Minderaa R, Anderson G, Volkmar F, Akkerhuis G, Cohen D. Noradrenergic and adrenergic functioning in autism. Biological Psychiatry 1994, 36: 237-241. PMID: 7986888, DOI: 10.1016/0006-3223(94)90605-x.Peer-Reviewed Original ResearchConceptsUrinary excretion rateNeurochemical assessmentVanillylmandelic acidAdrenergic functioningExcretion rateNormal control individualsUrinary excretionPlasma levelsNoradrenergic functioningMarked abnormalitiesNormal controlsGroup mean differencesControl groupControl individualsNorepinephrineMean differenceAutistic patientsAspartame, behavior, and cognitive function in children with attention deficit disorder.
Shaywitz B, Sullivan C, Anderson G, Gillespie S, Sullivan B, Shaywitz S. Aspartame, behavior, and cognitive function in children with attention deficit disorder. Pediatrics 1994, 93: 70-5. PMID: 7505423, DOI: 10.1542/peds.93.1.70.Peer-Reviewed Original ResearchConceptsAttention deficit disorderWisconsin Card Sorting TestDeficit disorderTreatment Emergent Symptom ScalePlacebo-controlled crossover studyComplete blood cell countStudy centersLiver function testsUrinary excretion rateBlood cell countAdministration of aspartameMental Disorders criteriaCognitive testsMeasurement of catecholaminesCrossover studyFunction testsMonoamine metabolismInpatient admissionsMetabolite excretionLarge dosesSymptom ScaleUsual consumptionCell countPlasma phenylalanineBiochemical measures
1993
Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism
Narayan M, Srinath S, Anderson G, Meundi DB. Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism. Biological Psychiatry 1993, 33: 630-635. PMID: 7687150, DOI: 10.1016/0006-3223(93)90102-j.Peer-Reviewed Original ResearchConceptsCSF homovanillic acidHomovanillic acidCerebrospinal fluid concentrationsCerebrospinal fluid levelsDopamine turnoverDopamine metabolitesCentral serotoninControl groupFluid levelsFluid concentrationsMarked alterationsGroup differencesAutistic disorderAutistic subjectsSerotoninChildrenAutistic childrenAlterationsGroupAutismPrevious studiesPlatelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
Cook E, Arora R, Anderson G, Berry-Kravis E, Yan S, Yeoh HC, Sklena P, Charak D, Leventhal B. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life Sciences 1993, 52: 2005-2015. PMID: 7684805, DOI: 10.1016/0024-3205(93)90685-v.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamideParoxetine bindingWhole bloodSubgroup of subjectsHyperserotonemia of autismProstaglandin E1Arginine vasopressinDensity of plateletsCAMP productionAcid diethylamideLSD bindingAutistic disorderSignificant differencesSignificant correlationBloodSubjectsBasalSubgroupsPlateletsChildrenAutistic probandsUptake VmaxAutistic children
1992
Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder
RIDDLE M, SCAHILL L, KING R, HARDIN M, ANDERSON G, ORT S, SMITH J, LECKMAN J, COHEN D. Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 1062-1069. PMID: 1429406, DOI: 10.1097/00004583-199211000-00011.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleEffective short-term treatmentSafety of fluoxetineFixed-dose trialCommon drug side effectsCY-BOCS total scoreMajor depressive disorderShort-term treatmentDrug side effectsMagnitude of improvementObsessive Compulsive ScaleFluoxetine groupPlacebo groupFluoxetine treatmentCrossover trialClinical trialsDepressive disorderObsessive-compulsive symptom severitySide effectsFluoxetineSymptom severityTotal scoreCompulsive Scale
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptoms