2004
Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey
Anderson GM, Barr CS, Lindell S, Durham AC, Shifrovich I, Higley JD. Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey. Psychopharmacology 2004, 178: 339-346. PMID: 15452685, DOI: 10.1007/s00213-004-2011-7.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsCisternal cerebrospinal fluid (CSF) samplesPg/Young adult male rhesus monkeysRhesus monkeysSerotonin reuptake inhibitorsAdult male rhesus monkeysPlasma drug levelsCerebrospinal fluid samplesExtent of elevationMale rhesus monkeysTime courseNon-human primatesAutoreceptor desensitizationSerotonin neurochemistryReuptake inhibitorsNeurochemical effectsResponse latencyProlonged administrationDrug levelsDrug accumulationDay 0SertralineDiscontinuationBaseline
1998
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Carpenter L, Anderson G, Pelton G, Gudin J, Kirwin P, Price L, Heninger G, McDougle C. Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects. Neuropsychopharmacology 1998, 19: 26-35. PMID: 9608574, DOI: 10.1016/s0893-133x(97)00198-x.Peer-Reviewed Original ResearchConceptsAmino acid drinkCerebrospinal fluidAcid drinkTRP levelsLow TRP dietTryptophan depletion paradigmBrain serotonin levelsPlasma TRP levelsHealthy adult subjectsHealthy human subjectsCSF TRP levelsPlasma TrpIndwelling catheterLumbar punctureSerotonin levelsTryptophan depletionContinuous cerebrospinal fluidSpecial dietAdult subjectsBehavioral effectsPlasma samplesHuman subjectsCorresponding fallCentral levelNadir
1997
Pathogenesis of Tourette's Syndrome
Leckman J, Peterson B, Anderson G, Arnsten A, Pauls D, Cohen D. Pathogenesis of Tourette's Syndrome. Journal Of Child Psychology And Psychiatry 1997, 38: 119-142. PMID: 9232461, DOI: 10.1111/j.1469-7610.1997.tb01508.x.Peer-Reviewed Original Research
1996
Adenosine diphosphate inhibits the serotonin transporter
Anderson G, Hall L, Horne W, Yang J. Adenosine diphosphate inhibits the serotonin transporter. Biochimica Et Biophysica Acta 1996, 1283: 14-20. PMID: 8765089, DOI: 10.1016/0005-2736(96)00073-9.Peer-Reviewed Original Research
1994
Noradrenergic and adrenergic functioning in autism
Minderaa R, Anderson G, Volkmar F, Akkerhuis G, Cohen D. Noradrenergic and adrenergic functioning in autism. Biological Psychiatry 1994, 36: 237-241. PMID: 7986888, DOI: 10.1016/0006-3223(94)90605-x.Peer-Reviewed Original ResearchConceptsUrinary excretion rateNeurochemical assessmentVanillylmandelic acidAdrenergic functioningExcretion rateNormal control individualsUrinary excretionPlasma levelsNoradrenergic functioningMarked abnormalitiesNormal controlsGroup mean differencesControl groupControl individualsNorepinephrineMean differenceAutistic patientsThe role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman J, Goodman W, North W, Chappell P, Price L, Pauls D, Anderson G, Riddle M, McDougle C, Barr L, Cohen D. The role of central oxytocin in obsessive compulsive disorder and related normal behavior. Psychoneuroendocrinology 1994, 19: 723-749. PMID: 7991761, DOI: 10.1016/0306-4530(94)90021-3.Peer-Reviewed Original ResearchConceptsForms of OCDObsessive-compulsive disorderCompulsive disorderCentral oxytocinFeatures of OCDDimensions of behaviorSeries of predictionsBehavioral symptomsOxytocinChallenge proceduresNormal behaviorSexual behaviorAnecdotal dataDisordersExtreme endsBehaviorAlternative hypothesisTreatment responseRelationship
1993
Integrating biological and behavioral perspectives in the study and care of autistic individuals: the future.
Cohen D, Volkmar F, Anderson G, Klin A. Integrating biological and behavioral perspectives in the study and care of autistic individuals: the future. Israel Journal Of Psychiatry And Related Sciences 1993, 30: 15-32. PMID: 8101835.Peer-Reviewed Original Research
1991
Use of high-performance liquid chromatography for assay of glutamic acid decarboxylase Its limitation in use for post-mortem brain
Chakraborty M, Lahiri P, Anderson G, Chatterjee D. Use of high-performance liquid chromatography for assay of glutamic acid decarboxylase Its limitation in use for post-mortem brain. Journal Of Chromatography 1991, 571: 235-240. PMID: 1810951, DOI: 10.1016/0378-4347(91)80450-q.Peer-Reviewed Original Research
1984
Radial arm maze performance in rats following neonatal dopamine depletion
Pearson D, Raskin L, Shywitz B, Anderson G, Cohen D. Radial arm maze performance in rats following neonatal dopamine depletion. Developmental Psychobiology 1984, 17: 505-517. PMID: 6434359, DOI: 10.1002/dev.420170508.Peer-Reviewed Original Research
1982
Effects of apomorphine on appetitive conditioning in 6-hydroxydopamine treated rat pups
Weldon D, Wool R, Teicher M, Shaywitz B, Cohen D, Anderson G. Effects of apomorphine on appetitive conditioning in 6-hydroxydopamine treated rat pups. Pharmacology Biochemistry And Behavior 1982, 17: 1281-1284. PMID: 6819587, DOI: 10.1016/0091-3057(82)90134-4.Peer-Reviewed Original ResearchConceptsApomorphine administrationRat pupsCombination of desmethylimipramineEffects of apomorphinePostnatal day 5Brain dopamineControl injectionsDrug treatmentNormal pupsIsotonic salineDay 5Appetitive responsesPupsImpaired performanceNext dayDesmethylimipramineApomorphineBaby formulaAnise odorAppetitive conditioningAdministrationSalineDopamineNovel odorAnimalsDetermination of Neurochemically Important Compounds in Physiological Samples Using HPLC
Anderson G, Young J. Determination of Neurochemically Important Compounds in Physiological Samples Using HPLC. Schizophrenia Bulletin 1982, 8: 333-348. PMID: 6180473, DOI: 10.1093/schbul/8.2.333.Peer-Reviewed Original Research
1981
Effects of bromocriptine in developing rat pups after 6-hydroxydopamine
Shaywitz B, Lipton S, Teicher M, Cohen D, Anderson G, Batter D, Young J. Effects of bromocriptine in developing rat pups after 6-hydroxydopamine. Pharmacology Biochemistry And Behavior 1981, 15: 443-448. PMID: 6794039, DOI: 10.1016/0091-3057(81)90275-6.Peer-Reviewed Original ResearchConceptsVehicle pupsHigh dosesDays of ageRat pupsCombination of desmethylimipramineInhibitory dopaminergic mechanismDoses of bromocriptineEffects of bromocriptineLittle clinical utilityGeneral motor activityAttention deficit disorderHole boxVehicle animalsDenervation supersensitivityDopaminergic mechanismsBrain dopamineClinical syndromeCommon disorderBromocriptineClinical utilityLonger observation periodPharmacological agentsPostnatal lifeMotor activityFirst month
1980
Environmental Influences on Body Weight and Behavior in Developing Rats After Neonatal 6-Hydroxydopamine
Pearson D, Teicher M, Shaywitz B, Cohen D, Young J, Anderson G. Environmental Influences on Body Weight and Behavior in Developing Rats After Neonatal 6-Hydroxydopamine. Science 1980, 209: 715-717. PMID: 7394533, DOI: 10.1126/science.7394533.Peer-Reviewed Original ResearchIndoleamine Metabolism in Rat Brain Studied Through Measurements of Tryptophan, 5‐Hydroxyindoleacetic Acid, and Indoleacetic Acid in Cerebrospinal Fluid
Young S, Anderson G, Purdy W. Indoleamine Metabolism in Rat Brain Studied Through Measurements of Tryptophan, 5‐Hydroxyindoleacetic Acid, and Indoleacetic Acid in Cerebrospinal Fluid. Journal Of Neurochemistry 1980, 34: 309-315. PMID: 6157779, DOI: 10.1111/j.1471-4159.1980.tb06598.x.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidIndoleamine metabolismCSF indoleacetic acidSelective monoamine oxidase inhibitorsMonoamine oxidase inhibitorsRat cerebrospinal fluidBrain tryptophanTryptophan loadMonoamine oxidase ATryptamine metabolismRat brainOxidase inhibitorsMeasurement of tryptophanBrainOxidase AHigh-performance liquid chromatographyMetabolismActive transport systemLiquid chromatographyB enzymeTryptamineBlood