1994
Aspartame, behavior, and cognitive function in children with attention deficit disorder.
Shaywitz B, Sullivan C, Anderson G, Gillespie S, Sullivan B, Shaywitz S. Aspartame, behavior, and cognitive function in children with attention deficit disorder. Pediatrics 1994, 93: 70-5. PMID: 7505423, DOI: 10.1542/peds.93.1.70.Peer-Reviewed Original ResearchConceptsAttention deficit disorderWisconsin Card Sorting TestDeficit disorderTreatment Emergent Symptom ScalePlacebo-controlled crossover studyComplete blood cell countStudy centersLiver function testsUrinary excretion rateBlood cell countAdministration of aspartameMental Disorders criteriaCognitive testsMeasurement of catecholaminesCrossover studyFunction testsMonoamine metabolismInpatient admissionsMetabolite excretionLarge dosesSymptom ScaleUsual consumptionCell countPlasma phenylalanineBiochemical measures
1990
Growth hormone and prolactin response to methylphenidate in children with attention deficit disorder
Shaywitz B, Shaywitz S, Sebrechts M, Anderson G, Cohen D, Jatlow P, Young J. Growth hormone and prolactin response to methylphenidate in children with attention deficit disorder. Life Sciences 1990, 46: 625-633. PMID: 2308471, DOI: 10.1016/0024-3205(90)90131-a.Peer-Reviewed Original Research
1987
Parotid Gland Salivary Secretion in Tourette's Syndrome and Attention Deficit Disorder: A Model System for the Study of Neurochemical Regulation
COHEN D, ORT S, CARUSO K, ANDERSON G, HUNT R, SHAYWITZ B, KREMENITZER M, LECKMAN J. Parotid Gland Salivary Secretion in Tourette's Syndrome and Attention Deficit Disorder: A Model System for the Study of Neurochemical Regulation. Journal Of The American Academy Of Child & Adolescent Psychiatry 1987, 26: 65-68. PMID: 3034852, DOI: 10.1097/00004583-198701000-00013.Peer-Reviewed Original ResearchConceptsAttention deficit disorderTourette syndromeSalivary amylase concentrationTS patientsAmylase concentrationSalivary secretionNeurochemical regulationReceptor functioningTreatment of TSDeficit disorderSalivary amylase secretionParotid gland secretionSingle dosesSalivary volumeClonidinePatientsAmylase secretionSyndromeADD patientsSalivary measuresSecretionTotal amylaseSalivary amylaseDisordersChildren
1986
Components of attention, methylphenidate dosage, and blood levels in children with attention deficit disorder.
Sebrechts M, Shaywitz S, Shaywitz B, Jatlow P, Anderson G, Cohen D. Components of attention, methylphenidate dosage, and blood levels in children with attention deficit disorder. Pediatrics 1986, 77: 222-8. PMID: 3945535, DOI: 10.1542/peds.77.2.222.Peer-Reviewed Original ResearchConceptsAttention deficit disorderDeficit disorderComponents of attentionDoses of methylphenidateCognitive resourcesCognitive componentsAttentional deficitsParent ratingsMethylphenidate dosageTest batteryMethylphenidateChildrenDisordersTaskDeficitsRatingsSingle testAttentionPerformanceTeachersBlood levelsBatteries
1984
Neurochemical Correlates of Attention Deficit Disorder
Raskin L, Shaywitz S, Shaywitz B, Anderson G, Cohen D. Neurochemical Correlates of Attention Deficit Disorder. Pediatric Clinics Of North America 1984, 31: 387-396. PMID: 6728523, DOI: 10.1016/s0031-3955(16)34584-9.Peer-Reviewed Original ResearchConceptsAttention deficit disorderDeficit disorderNeurochemical correlatesNeurotransmitter functionClinical investigationPharmacologic investigationsDisorders
1982
Psychopharmacology of attention deficit disorder; pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate
Shaywitz S, Hunt R, Jatlow P, Cohen D, Young J, Pierce R, Anderson G, Shaywitz B. Psychopharmacology of attention deficit disorder; pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate. Journal Of The American Academy Of Child & Adolescent Psychiatry 1982, 21: 593. DOI: 10.1097/00004583-198211000-00025.Peer-Reviewed Original ResearchAttention deficit disorderChronic treatmentDeficit disorderBehavioral measuresMethylphenidateNeuroendocrinePsychopharmacology of attention deficit disorder: pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate.
Shaywitz S, Hunt R, Jatlow P, Cohen D, Young J, Pierce R, Anderson G, Shaywitz B. Psychopharmacology of attention deficit disorder: pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate. Pediatrics 1982, 69: 688-94. PMID: 7079034, DOI: 10.1542/peds.69.6.688.Peer-Reviewed Original ResearchConceptsAcute studyMPH concentrationsGrowth hormoneObserved maximal concentrationCentral dopaminergic mechanismsPeak plasma concentrationAdministration of medicationsPharmacokinetics of methylphenidatePlasma growth hormoneConcentrations of methylphenidatePlasma MPH concentrationsAttention deficit disorderClinical responseChronic treatmentDopaminergic mechanismsGroup of childrenDisorders of attentionAbbreviated Conners' Rating ScaleSchool-aged childrenOral administrationPlasma concentrationsClinical pharmacologyMPH administrationProlactin concentrationsPercentage of improvementAssessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies
Young J, Cohen D, Shaywitz S, Caparulo B, Kavanagh M, Hunt R, Leckman J, Anderson G, Detlor J, Harcherik D, Shaywitz B. Assessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies. Schizophrenia Bulletin 1982, 8: 205-235. PMID: 6180470, DOI: 10.1093/schbul/8.2.205.Peer-Reviewed Original ResearchConceptsBrain functionPharmacological challenge testsSerious neuropsychiatric disorderClinical pediatric researchClinical research methodsSpecific neuronal systemsAttention deficit disorderClinical syndromeMetabolic dysfunctionTourette syndromeChallenge testClinical protocolsNew treatmentsClinical disordersNeuropsychiatric disordersNeuronal systemsClinical researchPediatric researchSyndromeDeficit disorderBest treatmentDisordersNovel biological strategiesLanguage disordersChildren
1981
Effects of bromocriptine in developing rat pups after 6-hydroxydopamine
Shaywitz B, Lipton S, Teicher M, Cohen D, Anderson G, Batter D, Young J. Effects of bromocriptine in developing rat pups after 6-hydroxydopamine. Pharmacology Biochemistry And Behavior 1981, 15: 443-448. PMID: 6794039, DOI: 10.1016/0091-3057(81)90275-6.Peer-Reviewed Original ResearchConceptsVehicle pupsHigh dosesDays of ageRat pupsCombination of desmethylimipramineInhibitory dopaminergic mechanismDoses of bromocriptineEffects of bromocriptineLittle clinical utilityGeneral motor activityAttention deficit disorderHole boxVehicle animalsDenervation supersensitivityDopaminergic mechanismsBrain dopamineClinical syndromeCommon disorderBromocriptineClinical utilityLonger observation periodPharmacological agentsPostnatal lifeMotor activityFirst month