1999
Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin
Nau G, Liaw L, Chupp G, Berman J, Hogan B, Young R. Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin. Infection And Immunity 1999, 67: 4223-4230. PMID: 10417195, PMCID: PMC96728, DOI: 10.1128/iai.67.8.4223-4230.1999.Peer-Reviewed Original ResearchConceptsOPN-null miceMycobacterial infectionAntigen-specific T-cell immunityMycobacterium bovis BCG infectionBacterial loadClearance of mycobacteriaT cell immunityGamma interferon productionWild-type miceNitric oxide productionMediators of resistanceAbility of osteopontinElevated bacterial loadHeavy bacterial loadMycobacterium bovis BCGBCG infectionSevere infectionsHost protectionMouse modelMacrophage defectHost responseInterferon productionCytokine osteopontinOxide productionInfection
1997
A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
Nau G, Guilfoile P, Chupp G, Berman J, Kim S, Kornfeld H, Young R. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6414-6419. PMID: 9177232, PMCID: PMC21064, DOI: 10.1073/pnas.94.12.6414.Peer-Reviewed Original ResearchMeSH KeywordsBronchopneumoniaCell LineChemokine CCL4Chemotactic FactorsCytokinesDNA PrimersFerritinsGene LibraryGranulomaHumansImmunohistochemistryMacrophage Inflammatory ProteinsMacrophagesMacrophages, AlveolarMycobacterium bovisMycobacterium tuberculosisOsteopontinPolymerase Chain ReactionSialoglycoproteinsSilicosisTranscription, GeneticTuberculosisConceptsHuman genome sequenceMacrophage cDNA libraryHost cell genesGranuloma formationOsteopontin gene expressionPrimary human alveolar macrophagesGenome sequenceMononuclear cell infiltrateMycobacterium tuberculosis infectionHost genesCDNA libraryCell genesGene expressionHuman alveolar macrophagesAssociation of osteopontinGenesExtracellular matrixPathologic responseCell infiltrateTuberculosis infectionGranulomatous pathologyChronic inflammationGranulomatous diseaseChemoattractant cytokinesMacrophage chemoattractant