2011
Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood
Bjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, Bardin PG, Bernstein DI, Irving LB, Chupp GL, Bensch GW, Bensch GW, Stahlman JE, Karetzky M, Baker JW, Miller RL, Goodman BH, Raible DG, Goldman SJ, Miller DK, Ryan JL, Dorner AJ, Immermann FW, O'Toole M. Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood. PLOS ONE 2011, 6: e21902. PMID: 21779351, PMCID: PMC3136489, DOI: 10.1371/journal.pone.0021902.Peer-Reviewed Original ResearchMeSH KeywordsAdultAsthmaFemaleGene Expression ProfilingHumansLeukocytes, MononuclearMaleMiddle AgedPolymerase Chain ReactionPrincipal Component AnalysisSignal TransductionConceptsPeripheral blood mononuclear cellsAsthma exacerbationsBlood mononuclear cellsMononuclear cellsAnalysis of PBMCsAntigen-independent T-cell activationMajor unmet clinical needHuman asthma exacerbationsBronchoalveolar lavage samplesUnmet clinical needT cell activationStable asthmaExacerbation episodesGene expression signaturesRespiratory infectionsAirway tissueLavage samplesAdaptive immunityExacerbationAnalysis of covarianceCell activationInnate immunityLymphocyte activationLevel of expressionClinical need
1997
A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
Nau G, Guilfoile P, Chupp G, Berman J, Kim S, Kornfeld H, Young R. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6414-6419. PMID: 9177232, PMCID: PMC21064, DOI: 10.1073/pnas.94.12.6414.Peer-Reviewed Original ResearchMeSH KeywordsBronchopneumoniaCell LineChemokine CCL4Chemotactic FactorsCytokinesDNA PrimersFerritinsGene LibraryGranulomaHumansImmunohistochemistryMacrophage Inflammatory ProteinsMacrophagesMacrophages, AlveolarMycobacterium bovisMycobacterium tuberculosisOsteopontinPolymerase Chain ReactionSialoglycoproteinsSilicosisTranscription, GeneticTuberculosisConceptsHuman genome sequenceMacrophage cDNA libraryHost cell genesGranuloma formationOsteopontin gene expressionPrimary human alveolar macrophagesGenome sequenceMononuclear cell infiltrateMycobacterium tuberculosis infectionHost genesCDNA libraryCell genesGene expressionHuman alveolar macrophagesAssociation of osteopontinGenesExtracellular matrixPathologic responseCell infiltrateTuberculosis infectionGranulomatous pathologyChronic inflammationGranulomatous diseaseChemoattractant cytokinesMacrophage chemoattractant