2011
Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood
Bjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, Bardin PG, Bernstein DI, Irving LB, Chupp GL, Bensch GW, Bensch GW, Stahlman JE, Karetzky M, Baker JW, Miller RL, Goodman BH, Raible DG, Goldman SJ, Miller DK, Ryan JL, Dorner AJ, Immermann FW, O'Toole M. Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood. PLOS ONE 2011, 6: e21902. PMID: 21779351, PMCID: PMC3136489, DOI: 10.1371/journal.pone.0021902.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAsthma exacerbationsBlood mononuclear cellsMononuclear cellsAnalysis of PBMCsAntigen-independent T-cell activationMajor unmet clinical needHuman asthma exacerbationsBronchoalveolar lavage samplesUnmet clinical needT cell activationStable asthmaExacerbation episodesGene expression signaturesRespiratory infectionsAirway tissueLavage samplesAdaptive immunityExacerbationAnalysis of covarianceCell activationInnate immunityLymphocyte activationLevel of expressionClinical need
2004
Asthma: Mechanisms of Disease Persistence and Progression
Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.BooksConceptsIL-13Key effector cytokineAnti-inflammatory therapyIL-13 productionProduction of chemokinesProgression of diseaseAirway fibrosisAllergic asthmaAirway remodelingEffector cytokinesEosinophilic inflammationPersistent diseaseTh2 cytokinesEpithelial damageDisease progressionInflammatory responseTh2 cellsMucus productionSmooth muscleBronchial airwaysMatrix metalloproteinasesAnimal dataAsthmaDisease persistenceInflammation