2023
Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials
Corren J, Menzies-Gow A, Chupp G, Israel E, Korn S, Cook B, Ambrose C, Hellqvist Å, Roseti S, Molfino N, Llanos J, Martin N, Bowen K, Griffiths J, Parnes J, Colice G. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 13-24. PMID: 37015033, PMCID: PMC10870853, DOI: 10.1164/rccm.202210-2005oc.Peer-Reviewed Original ResearchConceptsAsthma exacerbation rateUncontrolled asthmaExacerbation rateSecondary outcomesClinical trialsOverall populationRelevant subgroupsMeaningful reductionEfficacy of tezepelumabExacerbation-related hospitalizationsSafety of tezepelumabPlacebo-controlled trialEmergency department visitsInflammatory biomarker levelsNitric oxide levelsAdverse eventsAllergy statusBaseline bloodClinical characteristicsDepartment visitsPooled analysisNAVIGATOR trialBiomarker levelsOxide levelsTezepelumab
2011
The Lifestyle Interventions and Independence for Elders Study: Design and Methods
Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: Design and Methods. The Journals Of Gerontology Series A 2011, 66A: 1226-1237. PMID: 21825283, PMCID: PMC3193523, DOI: 10.1093/gerona/glr123.Peer-Reviewed Original ResearchConceptsMajor mobility disabilityMobility disabilityLifestyle interventionPrimary outcomeElders StudyModerate-intensity physical activity programImportant public health implicationsIntermediate functional outcomesOlder sedentary menPersistent mobility disabilityPhase 3 multicenterSedentary older personsSerious fall injuriesRegular physical activityPublic health priorityPhysical activity programHealth education programsPublic health implicationsSecondary outcomesSedentary menFunctional outcomeFall injuriesHealth priorityPhysical activityDaily living