2024
Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis.
Trujillo G, Regueiro-Ren A, Liu C, Hu B, Sun Y, Ahangari F, Fiorini V, Ishikawa G, Al Jumaily K, Khoury J, McGovern J, Lee C, Peng X, Pivarnik T, Sun H, Walia A, Woo S, Yu S, Antin-Ozerkis D, Sauler M, Kaminski N, Herzog E, Ryu C. Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2024 PMID: 39189851, DOI: 10.1164/rccm.202401-0065oc.Peer-Reviewed Original ResearchToll-like receptor 9Model of pulmonary fibrosisIdiopathic pulmonary fibrosisPulmonary fibrosisFibroproliferative responseLung diseaseIdiopathic pulmonary fibrosis cohortsExpression of toll-like receptor 9Toll-like receptor 9 activationTransplant-free survivalExpression of MCP-1Cohort of patientsSlow clinical progressionFibrotic lung diseaseAccelerated disease courseFatal lung diseaseIP-10Pharmacodynamic endpointsPreclinical modelsDisease courseClinical progressionPlasma mtDNAMCP-1Receptor 9Mouse modelSingle-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.
Unterman A, Zhao A, Neumark N, Schupp J, Ahangari F, Cosme C, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida T, Gomez J, Herazo-Maya J, Dela Cruz C, Herzog E, Kaminski N. Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 484-496. PMID: 38717443, PMCID: PMC11351796, DOI: 10.1164/rccm.202306-0979oc.Peer-Reviewed Original ResearchStable idiopathic pulmonary fibrosisIdiopathic pulmonary fibrosisPeripheral blood mononuclear cellsProgressive idiopathic pulmonary fibrosisPeripheral immune systemT cellsPulmonary fibrosisCohort of IPF patientsAssociated with decreased survivalIdiopathic pulmonary fibrosis patientsPeripheral blood mononuclear cell samplesPeripheral blood cell populationsImmune systemFraction of TregsRegulatory T cellsBlood mononuclear cellsBlood cell populationsFlow cytometry analysisImmune aberrationsIPF patientsTregsMononuclear cellsSingle-cell RNA sequencingLung homogenatesMonocyte chemoattractant
2023
α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis
Ishikawa G, Peng X, McGovern J, Woo S, Perry C, Liu A, Yu S, Ghincea A, Kishchanka A, Fiorini V, Hu B, Sun Y, Sun H, Ryu C, Herzog E. α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2023, 324: l639-l651. PMID: 36648147, PMCID: PMC10110730, DOI: 10.1152/ajplung.00119.2022.Peer-Reviewed Original ResearchConceptsAdrenergic nerve supplyIdiopathic pulmonary fibrosisΑ1 adrenoreceptorsPulmonary fibrosisNerve supplyCultured normal human lung fibroblastsInnate immune ligandsLung fibrosis modelNormal human lung fibroblastsSmooth muscle actinHuman lung fibroblastsAdrenal resectionAdrenoreceptor antagonismExtracellular mtDNAIPF cohortImproved survivalΑ1-adrenoreceptor antagonistsLung fibrosisAdrenal sourceFibroblast accumulationAdrenoreceptor antagonistBleomycin modelFibrosis modelLung fibrogenesisMouse model
2021
Evolving Perspectives on Innate Immune Mechanisms of IPF
Ishikawa G, Liu A, Herzog EL. Evolving Perspectives on Innate Immune Mechanisms of IPF. Frontiers In Molecular Biosciences 2021, 8: 676569. PMID: 34434962, PMCID: PMC8381017, DOI: 10.3389/fmolb.2021.676569.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisInnate immunityInnate immune populationsMolecular patternsMyeloid suppressor cellsInnate lymphoid cellsInnate immune mechanismsEpithelial-fibroblast interactionsRole of substancesSuppressor cellsPulmonary fibrosisImmune populationsImmune mechanismsDisease outcomePotential therapyLymphoid cellsHuman studiesFibrotic microenvironmentCommensal microbesAnimal modelingGenetic factorsImmunityFuture studiesComplex roleCells
2019
Concomitant Interstitial Lung Disease with Psoriasis
Ishikawa G, Dua S, Mathur A, Acquah SO, Salvatore M, Beasley MB, Padilla ML. Concomitant Interstitial Lung Disease with Psoriasis. Canadian Respiratory Journal 2019, 2019: 5919304. PMID: 31534591, PMCID: PMC6732645, DOI: 10.1155/2019/5919304.Peer-Reviewed Original ResearchConceptsNonspecific interstitial pneumoniaPneumonia patternConcomitant diagnosisConcomitant interstitial lung diseaseInterstitial lung disease patientsUsual interstitial pneumonia patternChronic hypersensitivity pneumonitisLung disease patientsCryptogenic organizing pneumoniaFurther prospective studiesIdiopathic pulmonary fibrosisInterstitial lung diseaseInterstitial pneumonia patternMount Sinai HospitalConcomitant psoriasisNSIP patternILD patientsImmunosuppressive therapyOrganizing pneumoniaInterstitial pneumoniaMedian ageRetrospective reviewCase seriesPulmonary fibrosisHypersensitivity pneumonitis
2018
Is It Idiopathic Pulmonary Fibrosis or Not?
Salvatore M, Ishikawa G, Padilla M. Is It Idiopathic Pulmonary Fibrosis or Not? The Journal Of The American Board Of Family Medicine 2018, 31: 151-162. PMID: 29330249, DOI: 10.3122/jabfm.2018.01.170288.Peer-Reviewed Original ResearchConceptsUsual interstitial pneumonitisPulmonary fibrosisInterstitial pneumonitisCorrect diagnosisAccurate diagnosisUIP/IPFChronic hypersensitivity pneumonitisIdiopathic pulmonary fibrosisNonspecific interstitial pneumonitisPulmonary fibrotic diseasesAmerican Thoracic SocietyAntifibrotic medicationsFibrotic sarcoidosisMean life expectancySerologic testingWorse prognosisCareful historyHypersensitivity pneumonitisThoracic SocietyFibrotic pathwaysInvasive proceduresClinician's abilityFibrotic diseasesPneumonitisFibrosis
2017
Elevated serum D-dimer level is associated with an increased risk of acute exacerbation in interstitial lung disease
Ishikawa G, Acquah SO, Salvatore M, Padilla ML. Elevated serum D-dimer level is associated with an increased risk of acute exacerbation in interstitial lung disease. Respiratory Medicine 2017, 128: 78-84. PMID: 28610674, DOI: 10.1016/j.rmed.2017.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlveolitis, Extrinsic AllergicBiomarkersChronic DiseaseDisease ProgressionFemaleFibrin Fibrinogen Degradation ProductsHospitalizationHumansIdiopathic Interstitial PneumoniasIdiopathic Pulmonary FibrosisL-Lactate DehydrogenaseLung Diseases, InterstitialMaleMiddle AgedMortalityOutcome Assessment, Health CarePredictive Value of TestsPrognosisPulmonary EmphysemaRetrospective StudiesRisk FactorsVenous ThromboembolismConceptsElevated serum D-dimer levelsSerum D-dimer levelsInterstitial lung diseaseD-dimer levelsAcute exacerbationRespiratory-related hospitalizationsSerum D-dimerD-dimer measurementVenous thromboembolismCause hospitalizationCause mortalityD-dimerLung diseaseOutcome measuresElevated serum D-dimerCollagen tissue diseasesSubsequent acute exacerbationChronic hypersensitivity pneumonitisSecondary outcome measuresHome oxygen therapyIdiopathic interstitial pneumoniaIdiopathic pulmonary fibrosisPrimary outcome measureSerum lactate dehydrogenaseInterstitial pneumonia