Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner
Wamsley JJ, Gary C, Biktasova A, Hajek M, Bellinger G, Virk R, Issaeva N, Yarbrough WG. Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner. Oncogenesis 2017, 6: e314-e314. PMID: 28394357, PMCID: PMC5520489, DOI: 10.1038/oncsis.2017.12.Peer-Reviewed Original ResearchDNA damage-induced cell deathDamage-induced cell deathSide effectsDNA damageDNA damaging treatmentsMutant p53Cell lung cancerSerious side effectsWild-type p53 cellsP53-dependent mannerCommon cancer therapiesMajority of cancersCell fateProtein bindsSensitivity of cellsLung cancerP53 regulatorsCellular DNACell deathDamage DNAMutation statusHuman cancersDamaging treatmentsAnticancer effectsType p53