1996
Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil
Yao G, Liu S, Chou E, Kukhanova M, Chu C, Cheng Y. Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil. Biochemical Pharmacology 1996, 51: 941-947. PMID: 8651944, DOI: 10.1016/0006-2952(96)00049-4.Peer-Reviewed Original ResearchConceptsEpstein-Barr virus replicationL-FMAUNovel L-nucleoside analogVirus replicationEBV DNA polymeraseMechanism of actionL-nucleoside analoguesEBV agentsPotent inhibitory activityAntiviral activityEBVVirus productionInhibitory concentrationViral productionHuman DNA polymerase alphaSelective inhibitorViral DNAInhibitory activityMetabolism studiesCell growthCellsInhibitionDNA polymerase alphaCellular DNANon-producing cells
1993
Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification
Yao G, Grill S, Egan W, Cheng Y. Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification. Antimicrobial Agents And Chemotherapy 1993, 37: 1420-1425. PMID: 8395789, PMCID: PMC187987, DOI: 10.1128/aac.37.7.1420.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEpstein-Barr virus genesEBV DNA synthesisMechanism of actionEBV DNAEBV replicationS-oligoDrug exposureEBV agentsInhibitory doseViral DNA polymeraseVirus productionDosePotent inhibitionPhosphorothioate oligodeoxynucleotidePotent inhibitorInhibitionCell growthCell culturesDNA synthesisVirus genes