1995
A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder
McDougle C, Kresch L, Goodman W, Naylor S, Volkmar F, Cohen D, Price L. A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. American Journal Of Psychiatry 1995, 152: 772-777. PMID: 7726318, DOI: 10.1176/ajp.152.5.772.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRepetitive thoughtsAutistic disorderAutistic groupSex-matched adultsSymptom ChecklistObsessive-compulsive groupDirect discriminant function analysisYale-Brown Obsessive Compulsive Scale Symptom ChecklistYale-Brown Obsessive Compulsive ScaleObsessive-compulsive symptomsCompulsive Scale Symptom ChecklistObsessive Compulsive ScaleAutistic patientsCase-control studyNeurobiological underpinningsSelf-mutilating behaviorCompulsive ScaleDiscriminant function analysisSomatic contentCounting behaviorConsecutive patientsPrimary diagnosisDisorders ClinicTreatment response
1992
Clomipramine in Autism: Preliminary Evidence of Efficacy
MCDOUGLE C, PRICE L, VOLKMAR F, GOODMAN W, WARD-O'BRIEN D, NIELSEN J, BREGMAN J, COHEN D. Clomipramine in Autism: Preliminary Evidence of Efficacy. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 746-750. PMID: 1644740, DOI: 10.1097/00004583-199207000-00025.Peer-Reviewed Original ResearchConceptsAutistic disorderPreliminary evidenceObsessive-compulsive symptomsSocial relatednessImpulsive behaviorCompulsive symptomsEfficacy of clomipramineYoung adultsPrevious evidenceClomipramine treatmentSerotonin neurotransmissionDisordersAutismClomipramineSymptomsTreatmentEfficacySignificant improvementAdultsEvidenceOutpatientsPathophysiologyNeurotransmissionRelatednessFindings