2003
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice
Chakrabarti S, Kobayashi KS, Flavell RA, Marks CB, Miyake K, Liston DR, Fowler KT, Gorelick FS, Andrews NW. Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice. Journal Of Cell Biology 2003, 162: 543-549. PMID: 12925704, PMCID: PMC2173791, DOI: 10.1083/jcb.200305131.Peer-Reviewed Original ResearchConceptsVII-deficient miceAntinuclear antibody responseInflammatory autoimmune diseasePolymyositis/dermatomyositisProgressive muscle weaknessCreatine kinase releaseInflammatory myopathiesAutoimmune myositisMuscle weaknessAutoimmune diseasesAutoimmune disordersExtensive fibrosisAntibody responseCollagen depositionDefective plasma membrane repairMembrane repairTrypanosoma cruzi invasionSkeletal muscleMiceExocytosis of lysosomesCruzi invasionInvasionPlasma membrane repairMouse tissuesLysosomal exocytosis
2001
Synapsin I is expressed in epithelial cells: localization to a unique trans-Golgi compartment.
Bustos R, Kolen E, Braiterman L, Baines A, Gorelick F, Hubbard A. Synapsin I is expressed in epithelial cells: localization to a unique trans-Golgi compartment. Journal Of Cell Science 2001, 114: 3695-704. PMID: 11707521, DOI: 10.1242/jcs.114.20.3695.Peer-Reviewed Original ResearchConceptsSynapsin ITrans-Golgi compartmentSynaptic vesicle exocytosisProtein kinase ANon-neuronal cell linesBrain synapsin IEpithelial cellsNorthern blot analysisTrafficking pathwaysVesicle exocytosisVesicular compartmentsKinase AMyosin IIGolgi complexLimited proteolysisAnti-synapsin antibodiesPre-synaptic terminalsPeptide mapsBlot analysisCell linesCompartmentsCellsNeural tissueLiver cellsCytoskeleton