2017
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models
Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z, Gukovsky I, Gukovskaya AS. Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models. Gastroenterology 2017, 154: 689-703. PMID: 29074451, PMCID: PMC6369139, DOI: 10.1053/j.gastro.2017.10.012.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsArginineAutophagyBile Acids and SaltsCalcium SignalingCeruletideCholine DeficiencyCyclophilin DCyclophilinsDisease Models, AnimalEndoplasmic Reticulum StressEthionineGenetic Predisposition to DiseaseHumansLipid MetabolismMembrane Potential, MitochondrialMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial Proton-Translocating ATPasesPancreasPancreatitisPhenotypeRatsTime FactorsTrehaloseConceptsDevelopment of APAcute pancreatitisEndoplasmic reticulum stressLipid metabolismImpaired autophagyMitochondrial dysfunctionAnimal modelsL-arginine-induced pancreatitisTreatment of APCyclophilin D knockout micePathogenesis of APAdministration of trehalosePancreatic ER stressParameters of pancreatitisReticulum stressSevere acute pancreatitisPancreas of miceDifferent animal modelsER stressPrincipal downstream effectorPancreatic injuryPathologic responsePancreatitis tissuesCyclophilin DNormal pancreas
1993
Influence of Chloroquine on Diet-Induced Pancreatitis
Leach S, Bilchik A, Karapetian O, Gorelick F, Modlin I. Influence of Chloroquine on Diet-Induced Pancreatitis. Pancreas 1993, 8: 64-69. PMID: 7678327, DOI: 10.1097/00006676-199301000-00013.Peer-Reviewed Original ResearchConceptsHigh-dose chloroquineAcidic subcellular compartmentsDiet-induced pancreatitisEthionine-supplemented dietRegular laboratory chowYoung female miceInfluence of chloroquineIntracellular zymogen activationCDE dietAcute pancreatitisContinuous infusionFemale miceLaboratory chowControl animalsPancreatitisExperimental pancreatitisAdditional potential effectsLow-pH compartmentsTrypsinogen contentPancreatic aciniChloroquineAcinar cellsTryptic activityAnimalsDigestive zymogens