Genetic and pharmacologic manipulation of vacuolar ATPase: Effects on zymogen activation in pancreatic acini
Kolodecik T, Gorelick F, Thrower E. Genetic and pharmacologic manipulation of vacuolar ATPase: Effects on zymogen activation in pancreatic acini. Open Access Animal Physiology 2009, Volume 1: 1-11. PMID: 21572923, PMCID: PMC3092382, DOI: 10.2147/oaap.s7252.Peer-Reviewed Original ResearchZymogen activationVacuolar ATPaseATP-dependent proton pumpTreatment of cellsGenetic approachesE subunitAcinar cellsProton pumpPancreatic acinar cellsPancreatitis responsesDigestive enzymesAcute pancreatitisPremature activationVATPaseSiRNAATPaseActivationSalicylihalamideCellsRecent studiesOrthologuesBaseline levelsHigh dosesPharmacologic manipulationAmylase secretion