2015
Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells
Messenger SW, Thomas D, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE. Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells. Cellular And Molecular Gastroenterology And Hepatology 2015, 1: 695-709. PMID: 26618189, PMCID: PMC4657148, DOI: 10.1016/j.jcmgh.2015.08.002.Peer-Reviewed Original ResearchEarly endosomesRecycling endosomesEndosomal traffickingLate endosomesDominant-negative Rab11a mutantCellular damage responseAssociated membrane proteinLysosome-Associated Membrane ProteinsPIKfyve inhibitionApical traffickingPIKfyve activityEndosomal systemCCK-8Damage responseMembrane proteinsPlasma membraneAcinar cellsPIKfyvePharmacological inhibitorsPancreatic acinar cellsTraffickingEndosomesZymogen activationAdenoviral overexpressionCellular death
1998
Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis
Otani T, Chepilko S, Grendell J, Gorelick F. Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis. American Journal Of Physiology 1998, 275: g999-g1009. PMID: 9815030, DOI: 10.1152/ajpgi.1998.275.5.g999.Peer-Reviewed Original ResearchConceptsAcinar cell compartmentNumber of vesiclesRecycling endosomesSupranuclear compartmentPancreatic acinar cellsTime-dependent mannerProcessing siteCell compartmentTrypsinogen processingPhysiological levelsZymogen granulesImmunofluorescence studiesCaerulein-induced pancreatitisAcinar cellsActivation peptideTrypsinogen activation peptidePathological activationCompartmentsActivation