Distribution of a Synthetic Protease Inhibitor in Rat Pancreatic Acini After Supramaximal Secretagogue Stimulation
Otani T, Atomi Y, Kuroda A, Muto T, Tamura M, Fukuda S, Akao S, Gorelick F. Distribution of a Synthetic Protease Inhibitor in Rat Pancreatic Acini After Supramaximal Secretagogue Stimulation. Pancreas 1997, 14: 142-149. PMID: 9057186, DOI: 10.1097/00006676-199703000-00006.Peer-Reviewed Original ResearchConceptsAcinar cellsPancreatic aciniProtease inhibitorsLow molecular weight protease inhibitorSynthetic protease inhibitorLarge cytoplasmic vacuolesIsolated pancreatic aciniRat pancreatic aciniAcute pancreatitisWeight protease inhibitorsZymogen granulesCerulein treatmentE3123Supramaximal secretagogue stimulationVivo modelElectron microscopic autoradiographyBeneficial effectsMin of incubationUnstimulated controlsMicroscopic autoradiographyInhibition of proteasesCytoplasmic vacuolesAciniPancreatitisFormation of vacuoles