2010
T1837 The Vacuolar ATPase Associates With CFTR in Apical Endocytic and Recycling Vesicles and Undergoes cAMP Regulated Trafficking in Intestinal Epithelial Cells
Collaco A, Jakab R, Gorelick F, Ameen N. T1837 The Vacuolar ATPase Associates With CFTR in Apical Endocytic and Recycling Vesicles and Undergoes cAMP Regulated Trafficking in Intestinal Epithelial Cells. Gastroenterology 2010, 138: s-589. DOI: 10.1016/s0016-5085(10)62715-1.Peer-Reviewed Original Research
2001
Synapsin I is expressed in epithelial cells: localization to a unique trans-Golgi compartment.
Bustos R, Kolen E, Braiterman L, Baines A, Gorelick F, Hubbard A. Synapsin I is expressed in epithelial cells: localization to a unique trans-Golgi compartment. Journal Of Cell Science 2001, 114: 3695-704. PMID: 11707521, DOI: 10.1242/jcs.114.20.3695.Peer-Reviewed Original ResearchConceptsSynapsin ITrans-Golgi compartmentSynaptic vesicle exocytosisProtein kinase ANon-neuronal cell linesBrain synapsin IEpithelial cellsNorthern blot analysisTrafficking pathwaysVesicle exocytosisVesicular compartmentsKinase AMyosin IIGolgi complexLimited proteolysisAnti-synapsin antibodiesPre-synaptic terminalsPeptide mapsBlot analysisCell linesCompartmentsCellsNeural tissueLiver cellsCytoskeleton
1993
Distribution of calcium/calmodulin-dependent protein kinase II in rat ileal enterocytes
Matovcik LM, Haimowitz B, Goldenring JR, Czernik AJ, Gorelick FS. Distribution of calcium/calmodulin-dependent protein kinase II in rat ileal enterocytes. American Journal Of Physiology 1993, 264: c1029-c1036. PMID: 8386447, DOI: 10.1152/ajpcell.1993.264.4.c1029.Peer-Reviewed Original ResearchConceptsProtein kinase IIDependent protein kinase IIKinase IICalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIDependent kinase activityRelative molecular massSpecific peptide inhibitorWide tissue distributionTerminal web regionIntestinal epithelial cellsEpithelial cytoskeletonKinase activityMyosin IISoluble subcellular fractionMolecular massRat ilealRat ileumMultiple substratesEnterocyte cytoskeletonImmunoreactive proteinMajor effectorPeptide inhibitorEpithelial cellsTissue distribution
1991
Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.
Marino CR, Matovcik LM, Gorelick FS, Cohn JA. Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. Journal Of Clinical Investigation 1991, 88: 712-716. PMID: 1713921, PMCID: PMC295422, DOI: 10.1172/jci115358.Peer-Reviewed Original ResearchConceptsCF transmembrane conductance regulatorCystic fibrosisTransmembrane conductance regulatorCFTR peptidesPancreatic secretory functionDouble-label immunofluorescence studiesConductance regulatorDuct epithelial cellsCystic fibrosis transmembrane conductance regulatorFibrosis transmembrane conductance regulatorPancreatic insufficiencyIntralobular duct cellsSecretory functionHuman pancreasCFTR moleculesChloride transportMonoclonal antibodiesApical domainDuct cellsAntibodiesEpithelial cellsAcinar cellsCFTR proteinImmunofluorescence studiesProtein products
1988
Development of Secretagogue Responsiveness in the Pancreas
Jamieson JD, Gorelick FS, Chang A. Development of Secretagogue Responsiveness in the Pancreas. Scandinavian Journal Of Gastroenterology 1988, 23: 98-103. PMID: 2852401, DOI: 10.3109/00365528809095920.Peer-Reviewed Original ResearchConceptsSecretory pathwaySecretory proteinsPancreatic acinar cellsEpithelial cell polarityDependent protein kinase IIRegulated secretory pathwayConstitutive secretory pathwayAcinar cellsProtein kinase IICell polarityMembrane proteinsPhosphorylated substratesRegulated secretionBasolateral domainCell biologyPlasmalemmal domainsPlasma membraneKinase IISecond messengerSecretagogue responsivenessFunctional specializationProteinEpithelial cellsPathwayZymogen granules