Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice
Chakrabarti S, Kobayashi KS, Flavell RA, Marks CB, Miyake K, Liston DR, Fowler KT, Gorelick FS, Andrews NW. Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice. Journal Of Cell Biology 2003, 162: 543-549. PMID: 12925704, PMCID: PMC2173791, DOI: 10.1083/jcb.200305131.Peer-Reviewed Original ResearchConceptsVII-deficient miceAntinuclear antibody responseInflammatory autoimmune diseasePolymyositis/dermatomyositisProgressive muscle weaknessCreatine kinase releaseInflammatory myopathiesAutoimmune myositisMuscle weaknessAutoimmune diseasesAutoimmune disordersExtensive fibrosisAntibody responseCollagen depositionDefective plasma membrane repairMembrane repairTrypanosoma cruzi invasionSkeletal muscleMiceExocytosis of lysosomesCruzi invasionInvasionPlasma membrane repairMouse tissuesLysosomal exocytosis