1996
Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells.
Matovcik LM, Maranto AR, Soroka CJ, Gorelick FS, Smith J, Goldenring JR. Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells. Journal Of Histochemistry & Cytochemistry 1996, 44: 1243-1250. PMID: 8918899, DOI: 10.1177/44.11.8918899.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium ChannelsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesCell PolarityDigestive SystemFluorescent Antibody Technique, IndirectInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIntestinal MucosaMaleRabbitsRatsRats, Sprague-DawleyReceptors, Cytoplasmic and NuclearConceptsType 3 InsP3 receptorCaM kinase IICalmodulin-dependent protein kinase IIKinase IIProtein kinase IIInsP3 receptorPotential phosphorylation sitesCalcium/calmodulin-dependent protein kinase IIType 3 inositolPhosphorylation sitesApical domainSubcellular localizationCytoskeletal domainTrisphosphate receptorPancreatic acinar cellsImmunofluorescence microscopyPhysiologic substratesGastrointestinal tissuesRabbit gastric glandsF-actin domainsGastrointestinal mucosal cellsIntestinal enterocytesApical regionAcinar cellsInositol
1991
Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.
Marino CR, Matovcik LM, Gorelick FS, Cohn JA. Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. Journal Of Clinical Investigation 1991, 88: 712-716. PMID: 1713921, PMCID: PMC295422, DOI: 10.1172/jci115358.Peer-Reviewed Original ResearchConceptsCF transmembrane conductance regulatorCystic fibrosisTransmembrane conductance regulatorCFTR peptidesPancreatic secretory functionDouble-label immunofluorescence studiesConductance regulatorDuct epithelial cellsCystic fibrosis transmembrane conductance regulatorFibrosis transmembrane conductance regulatorPancreatic insufficiencyIntralobular duct cellsSecretory functionHuman pancreasCFTR moleculesChloride transportMonoclonal antibodiesApical domainDuct cellsAntibodiesEpithelial cellsAcinar cellsCFTR proteinImmunofluorescence studiesProtein products