2021
Ketamine and xylazine effects in murine model of acute pancreatitis
Wang M, Gorelick FS. Ketamine and xylazine effects in murine model of acute pancreatitis. AJP Gastrointestinal And Liver Physiology 2021, 320: g1111-g1122. PMID: 33881355, PMCID: PMC8285583, DOI: 10.1152/ajpgi.00023.2021.Peer-Reviewed Original ResearchConceptsKet/XylAcute pancreatitis inductionPancreatitis inductionNeural pathwaysAcute pancreatitisPancreatitis severityAnesthetic agent administrationPancreatitis responsesMild acute pancreatitisExperimental animal modelsAcute pancreatitis severityAcute pancreatitis outcomesMarkers of autophagyXylazine effectsHourly injectionsC57BL/6 miceFuture studiesAnesthetic agentsAnesthetic combinationMurine modelVivo effectsAnesthesia administrationDisease processAnimal modelsAgent administration
2020
Zinc: Roles in pancreatic physiology and disease
Wang M, Phadke M, Packard D, Yadav D, Gorelick F. Zinc: Roles in pancreatic physiology and disease. Pancreatology 2020, 20: 1413-1420. PMID: 32917512, PMCID: PMC7572834, DOI: 10.1016/j.pan.2020.08.016.Peer-Reviewed Original ResearchConceptsZinc deficiencyReduced zinc levelsPancreatic injuryChronic pancreatitisAcute pancreatitisIL-1βInflammatory cytokinesGastrointestinal diseasesPancreatic diseaseIntestinal absorptionAnimal modelsMacrophage activationCalcium homeostasisNutritional deficienciesBiologic effectsPancreatic physiologyZinc levelsCellular changesDiseasePreliminary dataPancreatitisInflammationEssential trace elementDeficiencyCytokines
2017
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models
Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z, Gukovsky I, Gukovskaya AS. Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models. Gastroenterology 2017, 154: 689-703. PMID: 29074451, PMCID: PMC6369139, DOI: 10.1053/j.gastro.2017.10.012.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsArginineAutophagyBile Acids and SaltsCalcium SignalingCeruletideCholine DeficiencyCyclophilin DCyclophilinsDisease Models, AnimalEndoplasmic Reticulum StressEthionineGenetic Predisposition to DiseaseHumansLipid MetabolismMembrane Potential, MitochondrialMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial Proton-Translocating ATPasesPancreasPancreatitisPhenotypeRatsTime FactorsTrehaloseConceptsDevelopment of APAcute pancreatitisEndoplasmic reticulum stressLipid metabolismImpaired autophagyMitochondrial dysfunctionAnimal modelsL-arginine-induced pancreatitisTreatment of APCyclophilin D knockout micePathogenesis of APAdministration of trehalosePancreatic ER stressParameters of pancreatitisReticulum stressSevere acute pancreatitisPancreas of miceDifferent animal modelsER stressPrincipal downstream effectorPancreatic injuryPathologic responsePancreatitis tissuesCyclophilin DNormal pancreasDo Animal Models of Acute Pancreatitis Reproduce Human Disease?
Gorelick FS, Lerch MM. Do Animal Models of Acute Pancreatitis Reproduce Human Disease? Cellular And Molecular Gastroenterology And Hepatology 2017, 4: 251-262. PMID: 28752114, PMCID: PMC5518169, DOI: 10.1016/j.jcmgh.2017.05.007.Peer-Reviewed Original ResearchAcute pancreatitisBiological disease mechanismsNonmalignant gastrointestinal diseasesPathophysiological disease mechanismsDisease mechanismsPotential therapeutic targetPaucity of dataHospital admissionCommon causeExperimental pancreatitis modelGastrointestinal diseasesPancreatitis modelTherapeutic targetAnimal modelsNatural historySpecific causesDiseaseDisease modelsPancreatitisDisease developmentUnderlying cellMolecular mechanismsHuman diseasesCauseLimited information
2013
Models of Acute and Chronic Pancreatitis
Lerch MM, Gorelick FS. Models of Acute and Chronic Pancreatitis. Gastroenterology 2013, 144: 1180-1193. PMID: 23622127, DOI: 10.1053/j.gastro.2012.12.043.Peer-Reviewed Original ResearchConceptsChronic pancreatitisModels of AcuteInfluence of inflammationAutoimmune chronic pancreatitisChronic ethanol feedingCombination of lipopolysaccharideMechanisms of pathogenesisAcinar cell responsesHuman diseasesPancreatic cancerSevere diseaseRodent modelsEthanol feedingSupraphysiologic concentrationsPancreatitisPancreatitis modelAnimal modelsTherapeutic interventionsCell responsesDiseaseFurther characterizationEarly stagesAcuteInflammationCholecystokinin
2011
Investigating the Pathobiology of Alcoholic Pancreatitis
Pandol SJ, Lugea A, Mareninova OA, Smoot D, Gorelick FS, Gukovskaya AS, Gukovsky I. Investigating the Pathobiology of Alcoholic Pancreatitis. Alcohol Clinical And Experimental Research 2011, 35: 830-837. PMID: 21284675, PMCID: PMC3083481, DOI: 10.1111/j.1530-0277.2010.01408.x.Peer-Reviewed Original ResearchConceptsAlcoholic pancreatitisAlcohol-induced pancreatitisPotential therapeutic strategyDuration of drinkingKey cellular organellesEffects of alcoholCigarette smokingClinical benefitDietary factorsCommon causeEpidemiologic studiesPancreatitisTherapeutic strategiesAlcohol abuseAnimal modelsHeavy drinkersDisease initiationPathobiologic processesAlcohol effectsCellular organellesMolecular mechanismsEndoplasmic reticulumRecent findingsCurrent studySmoking
2008
Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator
Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ, Gorelick F. Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator. Gastroenterology 2008, 136: 331-340.e2. PMID: 18996124, PMCID: PMC2833423, DOI: 10.1053/j.gastro.2008.09.065.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorEthanol-induced hepatic steatosisEthanol-induced steatosisMMP-2/9 activityPEDF levelsHepatic steatosisEthanol feedingLoss of PEDFAnimal modelsTriglyceride contentRecombinant pigment epithelium-derived factorNovel lipid regulatorLiver triglyceride contentLiver biopsy specimensEpithelium-derived factorEthanol fed animalsNormal liver samplesAccumulation of lipidsHistologic steatosisBiopsy specimensClinical studiesEthanol exposureHepatocellular carcinomaSteatosisPigment epitheliumMolecular basis for pancreatitis
Thrower E, Husain S, Gorelick F. Molecular basis for pancreatitis. Current Opinion In Gastroenterology 2008, 24: 580-585. PMID: 19122498, PMCID: PMC3030809, DOI: 10.1097/mog.0b013e32830b10e6.Peer-Reviewed Original ResearchConceptsChronic pancreatitisAcute pancreatitisPain responseAnimal modelsToll-like receptor 4Transient receptor potential vanilloid subtype 1Specific neural receptorsSevere acute pancreatitisBasic science studiesChymotrypsin CShock protein 70Neural receptorsReceptor 4Chronic diseasesPancreatitisAlcohol abuseReceptor 2Subtype 1Potential treatmentPilot studyProtective mechanismAcinar cellsProtein 70Genetic factorsYear findings
2002
Acute pancreatitis
Nagar AB, Gorelick FS. Acute pancreatitis. Current Opinion In Gastroenterology 2002, 18: 552-557. PMID: 17033332, DOI: 10.1097/00001574-200209000-00005.Peer-Reviewed Original ResearchSystemic inflammatory responseAcute pancreatitisInflammatory responseDistant organ failureMultiple inciting factorsEndoscopic retrograde cholangiopancreatography (ERCP) resultsSpecific inflammatory mediatorsAcute pancreatic injuryHuman acute pancreatitisExperimental acute pancreatitisIntra-acinar activationRelease of cytokinesClinical acute pancreatitisMultiorgan failurePancreatic injuryOrgan failureProinflammatory mediatorsInflammatory mediatorsCascade of eventsClinical syndromePancreatitisAnimal modelsInciting factorsMajor determinantMediators