2009
How to Identify the Asymptomatic High-Risk Patient?
Schuijf J, Achenbach S, Zoghbi W, Boersma E, Raggi P, Weber M, Nagel E, Narula J, Wackers F, Poldermans D, Bax J. How to Identify the Asymptomatic High-Risk Patient? Current Problems In Cardiology 2009, 34: 539-577. PMID: 19804855, DOI: 10.1016/j.cpcardiol.2009.07.001.Peer-Reviewed Original ResearchConceptsElevated riskAsymptomatic high-risk patientsCardiovascular disease eventsHigh-risk patientsCause of mortalityUse of biomarkersNoninvasive imaging modalityIntermediate riskAsymptomatic individualsCardiovascular diseaseHigh riskDisease eventsPreventive measuresImaging modalitiesSubstantial proportionMorbidityPatientsRisk assessmentAdditional strategiesRiskMortalityTraditional risk assessmentLarge proportionGreat benefitIndividualsDetection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging
Senior R, Monaghan M, Main M, Zamorano J, Tiemann K, Agati L, Weissman N, Klein A, Marwick T, Ahmad M, DeMaria A, Zabalgoitia M, Becher H, Kaul S, Udelson J, Wackers F, Walovitch R, Picard M. Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. European Heart Journal - Cardiovascular Imaging 2009, 10: 26-35. PMID: 19131498, DOI: 10.1093/ejechocard/jen321.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overArea Under CurveContrast MediaCoronary Artery DiseaseDipyridamoleEchocardiography, StressFemaleFluorocarbonsGated Blood-Pool ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedInternational CooperationMaleMiddle AgedObserver VariationROC CurveSensitivity and SpecificityStatistics, NonparametricTomography, Emission-Computed, Single-PhotonYoung AdultConceptsChest pain patientsPain patientsStress echocardiographyPerfusion imagingNon-inferior sensitivityPhase 3 trialCoronary artery diseaseCoronary artery disease detectionQuantitative coronary angiographyNon-inferiority analysisRadionuclide perfusion imagingSingle photon emissionAdverse eventsArtery diseaseCoronary angiographyBlinded cardiologistsClinical reviewDipyridamole stressMyocardial perfusionSPECT perfusionInternational trialRAMP 1Diagnostic performanceSPECTCharacteristic curve
2008
Different manifestations of coronary artery disease by stress SPECT myocardial perfusion imaging, coronary calcium scoring, and multislice CT coronary angiography in asymptomatic patients with type 2 diabetes mellitus
Scholte A, Schuijf J, Kharagjitsingh A, Dibbets-Schneider P, Stokkel M, Jukema J, van der Wall E, Bax J, Wackers F. Different manifestations of coronary artery disease by stress SPECT myocardial perfusion imaging, coronary calcium scoring, and multislice CT coronary angiography in asymptomatic patients with type 2 diabetes mellitus. Journal Of Nuclear Cardiology 2008, 15: 503-509. PMID: 18674717, DOI: 10.1016/j.nuclcard.2008.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCalcinosisComorbidityCoronary Artery DiseaseDiabetes Mellitus, Type 2FemaleHumansIncidenceMaleMiddle AgedNetherlandsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedVentricular Dysfunction, LeftConceptsType 2 diabetes mellitusCoronary artery diseaseMSCT coronary angiographyAsymptomatic patientsCoronary angiographyDiabetes mellitusPositive CAC scoreMyocardial perfusion imagingCAC scoreCoronary atherosclerosisArtery diseaseCAC scoringCalcium scoringPerfusion imagingAbnormal diagnostic test resultsSilent coronary artery diseaseStress single-photon emissionCoronary artery calcium scoringMultislice CT coronary angiographyTomography myocardial perfusion imagingStress SPECT myocardial perfusion imagingSilent coronary atherosclerosisSPECT myocardial perfusion imagingRelative prognostic valueTomographic coronary angiography
2006
Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging
Papaioannou GI, Kasapis C, Seip RL, Grey NJ, Katten D, Wackers FJ, Inzucchi SE, Engel S, Taylor A, Young LH, Chyun DA, Davey JA, Iskandrian AE, Ratner RE, Robinson EC, Carolan S, Heller GV. Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging. Journal Of Nuclear Cardiology 2006, 13: 362-368. PMID: 16750781, DOI: 10.1016/j.nuclcard.2006.01.022.Peer-Reviewed Original ResearchConceptsEndothelium-dependent vasodilationEndothelium-independent vasodilationCoronary artery diseaseMyocardial perfusion imagingRelative myocardial ischemiaAsymptomatic patientsEndothelial functionNegative predictive valueMyocardial ischemiaAsymptomatic type 2 diabetic patientsExclusion of CADPredictive valueAdenosine myocardial perfusion imagingPeripheral vascular endothelial functionType 2 diabetic patientsType 2 diabetes mellitusHigh negative predictive valueAsymptomatic Diabetics (DIAD) studyBrachial artery ultrasonographyVascular endothelial functionDetection of ischemiaEDV responseRelative ischemiaEndothelial dysfunctionOvert atherosclerosisTo the editor
Venkataraman R, Al-Shaer M, Wackers F. To the editor. Journal Of Nuclear Cardiology 2006, 13: 300-300. DOI: 10.1007/bf02971255.Peer-Reviewed Original ResearchAdultAgedBlood Flow VelocityBrachial ArteryCoronary Artery DiseaseData Interpretation, StatisticalEndothelium, VascularExercise TestFemaleHumansIncidenceMaleRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySeverity of Illness IndexThalliumUltrasonographyLetter to the Editor
Venkataraman R, Al-Shaer M, Wackers F. Letter to the Editor. Journal Of Nuclear Cardiology 2006, 13: 300. PMID: 16580967, DOI: 10.1016/j.nuclcard.2006.01.009.Peer-Reviewed Original ResearchAdultAgedBlood Flow VelocityBrachial ArteryCoronary Artery DiseaseData Interpretation, StatisticalEndothelium, VascularExercise TestFemaleHumansIncidenceMaleRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySeverity of Illness IndexThalliumUltrasonography
2005
A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Intravenous MCC-135 as an Adjunct to Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction: Rationale and Design of the Evaluation of MCC-135 for Left Ventricular Salvage in Acute MI (EVOLVE) Study
Jang I, Pettigrew V, Picard M, Kowey P, Demmel V, Zile M, Tatsuno J, Wackers F, Hibberd M. A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Intravenous MCC-135 as an Adjunct to Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction: Rationale and Design of the Evaluation of MCC-135 for Left Ventricular Salvage in Acute MI (EVOLVE) Study. Journal Of Thrombosis And Thrombolysis 2005, 20: 147-153. PMID: 16261287, DOI: 10.1007/s11239-005-3267-4.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultAngioplasty, Balloon, CoronaryBenzenesulfonatesCalciumDouble-Blind MethodEchocardiographyHumansMaleMiddle AgedMuscle CellsMyocardial InfarctionMyocardial Reperfusion InjuryNecrosisPiperazinesRadiographyTomography, Emission-Computed, Single-PhotonVentricular Function, LeftConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionLeft Ventricular SalvageElevation myocardial infarctionPlacebo-controlled clinical trialMCC-135Percutaneous coronary interventionIntracellular calcium overloadMyocardial infarctionPost-myocardial infarctionVentricular functionCalcium overloadEVOLVE studyCoronary interventionAdjunct therapyInfarct sizeClinical trialsPrimary PCIAcute ST-elevation myocardial infarctionMI studiesVentricular ejection fractionSerum cardiac markersAcute myocardial infarctionEarly clinical studiesMyocardial infarction sizeNew hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation
Liu YH, Sinusas AJ, Khaimov D, Gebuza BI, Wackers FJ. New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation. Journal Of Nuclear Cardiology 2005, 12: 55-65. PMID: 15682366, DOI: 10.1016/j.nuclcard.2004.09.015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsElectrocardiographyFemaleGated Blood-Pool ImagingHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexStroke VolumeTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, Left
2003
Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction
Navare SM, Wackers FJ, Liu YH. Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction. European Journal Of Nuclear Medicine And Molecular Imaging 2003, 30: 1330-1337. PMID: 12838373, DOI: 10.1007/s00259-003-1231-0.Peer-Reviewed Original ResearchConceptsSingle photon emission tomographyEnd-diastolic volumeEnd-systolic volumePerfusion defectsEjection fractionMyocardial perfusionSPET imagesLV volumesLeft ventricular end-diastolic volumeVentricular end-diastolic volumeSmaller end-systolic volumeLarger end-diastolic volumeSignificant perfusion defectsMyocardial perfusion defectsRadiotracer doseHigher LVEFVentricular functionLow doseVentricular volumeEmission tomographyLV parametersDoseLVEFECG gatingPatients
2001
Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients
Russell R, Chyun D, Song S, Sherwin R, Tamborlane W, Lee F, Pfeifer M, Rife F, Wackers F, Young L. Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients. AJP Endocrinology And Metabolism 2001, 281: e1029-e1036. PMID: 11595660, DOI: 10.1152/ajpendo.2001.281.5.e1029.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiac OutputCatecholaminesChemical PrecipitationDiabetes Mellitus, Type 1DiastoleEpinephrineFatty Acids, NonesterifiedFemaleGlucagonGlucose Clamp TechniqueHeartHeart RateHumansHydrocortisoneHypoglycemiaInsulinLactic AcidMaleNorepinephrinePolyethylene GlycolsStroke VolumeSystoleVentricular Function, LeftConceptsType 1 diabetic patientsInsulin-induced hypoglycemiaNondiabetic groupType 1 diabetesDiabetic subjectsEuglycemic hyperinsulinemiaDiabetic patientsNondiabetic subjectsCardiac responseLeft ventricular systolicHealthy nondiabetic subjectsEquilibrium radionuclide angiographyDiabetic groupDiastolic functionVentricular systolicCardiovascular consequencesVentricular functionBlunted increaseCardiac outputGlucagon concentrationsPlasma catecholaminesRadionuclide angiographyInsulin infusionEuglycemic conditionsHypoglycemiaSelective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center
Abbott B, Abdel-Aziz I, Nagula S, Monico E, Schriver J, Wackers F. Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center. The American Journal Of Cardiology 2001, 87: 1351-1355. PMID: 11397352, DOI: 10.1016/s0002-9149(01)01551-x.Peer-Reviewed Original ResearchConceptsChest pain centerChest pain patientsCoronary artery diseasePain patientsSingle photon emissionChest painPain centerArtery diseaseMyocardial infarctionEmergency department chest pain centersEmergency department chest pain patientsTomography myocardial perfusion imagingTomography myocardial perfusionAcute myocardial infarctionMyocardial perfusion imagingSelective useCPC patientsNonischemic electrocardiogramHospital dischargeAppropriate patientsHospital admissionFinal diagnosisMyocardial perfusionPatientsPerfusion imagingDobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy
Ramahi T, Longo M, Cadariu A, Rohlfs K, Slade M, Carolan S, Vallejo E, Wackers F. Dobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy. European Heart Journal 2001, 22: 849-856. PMID: 11350094, DOI: 10.1053/euhj.2001.2654.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionTransplant-free survivalEjection fractionHeart failureVentricular end-diastolic volume indexOverall transplant-free survivalPeak exercise oxygen consumptionSevere non-ischaemic cardiomyopathyEnd-diastolic volume indexFunctional classStrongest prognostic variableChronic heart failureHeart failure patientsPrognosis of patientsNon-ischemic cardiomyopathyExercise oxygen consumptionEquilibrium radionuclide ventriculographyVentriculographic variablesExercise capacityFailure patientsPrognostic valueRadionuclide ventriculographyIntravenous infusionDeltaLVEFLeft ventricular inotropic reserve and right ventricular function predict increase of left ventricular ejection fraction after beta-blocker therapy in nonischemic cardiomyopathy
Ramahi T, Longo M, Cadariu A, Rohlfs K, Carolan S, Engle K, Samady H, Wackers F. Left ventricular inotropic reserve and right ventricular function predict increase of left ventricular ejection fraction after beta-blocker therapy in nonischemic cardiomyopathy. Journal Of The American College Of Cardiology 2001, 37: 818-824. PMID: 11693757, DOI: 10.1016/s0735-1097(00)01162-1.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionRight ventricular ejection fractionBeta-blocker therapyVentricular ejection fractionVentricular inotropic reserveNonischemic cardiomyopathyEjection fractionInotropic reserveDobutamine infusionLong-term beta-blocker therapyNormal right ventricular ejection fractionImprovement of LVEFBeta-blocker doseRight ventricular functionSystolic blood pressureIntravenous dobutamine infusionEquilibrium radionuclide ventriculographyVentriculographic variablesLVEF increaseBlood pressureVentricular functionRadionuclide ventriculographyUnderwent assessmentIntravenous infusionBaseline variables
2000
Atypical fatal hypocomplementemic urticarial vasculitis with involvement of native and homograft aortic valves in an African American man
Hong L, Wackers F, Dewar M, Kashgarian M, Askenase P. Atypical fatal hypocomplementemic urticarial vasculitis with involvement of native and homograft aortic valves in an African American man. Journal Of Allergy And Clinical Immunology 2000, 106: 1196-1198. PMID: 11112906, DOI: 10.1067/mai.2000.110805.Peer-Reviewed Original ResearchAssociation of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures
Mattera J, de Leon C, Wackers F, Williams C, Wang Y, Krumholz H. Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures. American Heart Journal 2000, 140: 409-418. PMID: 10966538, DOI: 10.1067/mhj.2000.108518.Peer-Reviewed Original ResearchConceptsGeneral health perceptionHealth-related qualityPhysical functioningHealth perceptionMyocardial perfusion imagingHealth statusExercise testingPerfusion imagingMedical Outcomes Study Short Form SurveyPatients' health-related qualityShort Form SurveyAssociation of patientGeneral health statusImportant outcome measureSuccess of treatmentConsecutive patientsSF-36Metabolic equivalentsNoninvasive testingExercise testPatient outcomesIndividual patientsOutcome measuresForm SurveyPatient's viewpointAssessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography
Vallejo E, Dione D, Sinusas A, Wackers F. Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography. Journal Of Nuclear Cardiology 2000, 7: 461-470. PMID: 11083195, DOI: 10.1067/mnc.2000.107820.Peer-Reviewed Original ResearchConceptsVentricular ejection fractionEjection fractionPatient studiesLeft ventricular ejection fractionExtracardiac activityFirst-pass radionuclide angiographyLarger end-diastolic volumeStress-induced ischemiaEnd-diastolic volumeQuantitative gated SPECTSingle photon emissionAbnormal LVEFNormal LVEFRadionuclide angiographyDiastolic volumeLVEFPerfusion defectsLVEF valuesSame patientHeart sizeLeft ventricleGated SPECTSPECT studiesQGSMean rest
1999
Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome
Samady H, Elefteriades J, Abbott B, Mattera J, McPherson C, Wackers F. Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome. Circulation 1999, 100: 1298-1304. PMID: 10491374, DOI: 10.1161/01.cir.100.12.1298.Peer-Reviewed Original ResearchConceptsVentricular functionIschemic cardiomyopathyGroup AHeart failure scoreLeft ventricular functionIschemic LV dysfunctionPoor patient outcomesB. Group ALack of improvementBaseline LVEFEffective revascularizationImproved LVEFCoronary revascularizationLV dysfunctionConsecutive patientsIntraoperative variablesPostoperative improvementCardiac deathLV functionPoor outcomeViable myocardiumLVEF assessmentIschemic myocardiumPatient outcomesWorse outcomesEjection fraction by radionuclide ventriculography and contrast left ventriculogram A tale of two techniques
Ureña P, Lamas G, Mitchell G, Flaker G, Smith S, Wackers F, McEwan P, Pfeffer M, investigators F. Ejection fraction by radionuclide ventriculography and contrast left ventriculogram A tale of two techniques. Journal Of The American College Of Cardiology 1999, 33: 180-185. PMID: 9935027, DOI: 10.1016/s0735-1097(98)00533-6.Peer-Reviewed Original ResearchConceptsRadionuclide ventriculographyEjection fractionCardiovascular eventsEvent ratesMyocardial infarctionPostinfarct patientsIndependent predictorsRisk stratificationAssess prognosisClinical eventsVentricular performanceClinical impressionPatientsMultivariate analysisPrognosisVentriculographyTercileEF measurementsBest predictorPredictorsComparative abilityCatheterizationInfarctionVentriculograms
1998
Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy
Mattera J, Arain S, Sinusas A, Finta L, Wackers F. Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy. Journal Of Nuclear Cardiology 1998, 5: 498-506. PMID: 9796897, DOI: 10.1016/s1071-3581(98)90181-7.Peer-Reviewed Original ResearchConceptsExercise myocardial perfusion imagingCoronary artery diseaseNormal exercise electrocardiogramMyocardial perfusion imagingNormal myocardial perfusion imagingNormal resting electrocardiogramsExercise electrocardiogramExercise testingArtery diseaseIntermediate likelihoodResting electrocardiogramsAbnormal myocardial perfusion imagingDiagnostic strategiesAbnormal exercise electrocardiogramGroup 3 patientsHard cardiac eventsNonfatal myocardial infarctionNormal baseline electrocardiogramSubsequent coronary revascularizationIncremental diagnostic informationDiagnostic testing strategiesCoronary revascularizationCardiac eventsUnstable anginaConsecutive patients
1997
Effect of left ventricular function on the assessment of myocardial viability by technectium-99m sestamibi and correlation with positron emission tomography in patients with healed myocardial infarcts or stable angina pectoris, or both
Arrighi J, Ng C, Dey H, Wackers F, Soufer R. Effect of left ventricular function on the assessment of myocardial viability by technectium-99m sestamibi and correlation with positron emission tomography in patients with healed myocardial infarcts or stable angina pectoris, or both. The American Journal Of Cardiology 1997, 80: 1007-1013. PMID: 9352969, DOI: 10.1016/s0002-9149(97)00594-8.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePositron emission tomographyLV dysfunctionArtery diseaseGroup 2Myocardial viabilityGroup 1Ejection fractionModerate coronary artery diseaseEmission tomographyModerate LV dysfunctionSevere LV dysfunctionStable angina pectorisLV ejection fractionGlobal LV dysfunctionAccuracy of technetiumSingle photon emissionSemiquantitative SPECTVentricular dysfunctionViability detectionAngina pectorisVentricular functionReduced perfusionSestamibi SPECTMyocardial infarct