1998
Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging.
Wu JC, Yun JJ, Heller EN, Dione DP, DeMan P, Liu YH, Zaret BL, Wackers FJ, Sinusas AJ. Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging. Journal Of Nuclear Medicine 1998, 39: 417-25. PMID: 9529285.Peer-Reviewed Original ResearchConceptsSingle-vessel stenosisMyocardial blood flowDobutamine stressCoronary stenosisTechnetium-99mBlood flowLeft circumflex artery stenosisCircumflex artery stenosisFlow deficitsSingle coronary stenosisCoronary artery diseaseRate-pressure productRegional myocardial blood flowLeft ventricular pressurePeak dobutamine stressOpen-chest dogsNonischemic flowArtery diseaseArtery stenosisPeak dobutamineSestamibi activitySevere stenosisVentricular pressureSestamibi imagingIschemic zone
1995
962-67 Dobutamine Stress has a Limited Value for Enhancing Flow Heterogeneity in the Presence of a Moderate Stenosis When Used in Conjunction with Tc99m-Sestamibi Imaging
Yun J, Wu J, Heller E, Deckelbaum L, Dione D, Liu Y, Wackers F, Sinusas A. 962-67 Dobutamine Stress has a Limited Value for Enhancing Flow Heterogeneity in the Presence of a Moderate Stenosis When Used in Conjunction with Tc99m-Sestamibi Imaging. Journal Of The American College Of Cardiology 1995, 25: 217a. DOI: 10.1016/0735-1097(95)92360-h.Peer-Reviewed Original ResearchMB activityModerate stenosisDOB stressMean aortic pressureOpen-chest dogsSPECT perfusion imagingLCX stenosisProximal LCXPeak dobutamineAortic pressureDobutamine stressMB injectionChest dogsHeart rateNonischemicStenosisDobutamineIschemic regionPerfusion imagingFlow probeRadiolabeled microspheresFlow deficitsMicrosphere flowLimited valueBaseline
1994
Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia.
Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL. Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. Journal Of Nuclear Medicine 1994, 35: 664-71. PMID: 8151391.Peer-Reviewed Original ResearchConceptsTechnetium-99mCanine modelPerfusion tracerMicrosphere flowCoronary artery occlusionInitial myocardial uptakeIntact canine modelOpen-chest dogsMyocardial perfusion imagingMyocardial blood flowDynamic planar imagingArtery occlusionPharmacological vasodilatationPharmacological stressMyocardial perfusion tracersMyocardial uptakeRadiotracer injectionBlood flowMyocardial perfusionPerfusion imagingArterial samplingMyocardial flowBackground activity ratioTetrofosminIschemia
1993
Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size.
Sinusas AJ, Shi Q, Vitols PJ, Fetterman RC, Maniawski P, Zaret BL, Wackers FJ. Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size. Circulation 1993, 88: 2224-2234. PMID: 8222117, DOI: 10.1161/01.cir.88.5.2224.Peer-Reviewed Original ResearchConceptsHours of reperfusionDobutamine stressMyocardial thickeningVentricular geometryDefect magnitudeCoronary artery occlusionLeft ventricular geometryOpen-chest dogsRegional ventricular functionCircumferential profile analysisDefect sizeMIBI defectsArtery occlusionMyocardial salvageVentricular functionVentricular sizePharmacological stressNonviable myocardiumES imagesMyocardial perfusionInfarcted dogsRegional functionReperfusionRisk areasDogs