1995
Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia.
Shi CQ, Sinusas AJ, Dione DP, Singer MJ, Young LH, Heller EN, Rinker BD, Wackers FJ, Zaret BL. Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. Journal Of Nuclear Medicine 1995, 36: 1078-86. PMID: 7769431.Peer-Reviewed Original ResearchConceptsIschemic regionMyocardial ischemiaBlood flowEx vivo SPECTRegional myocardial blood flowPartial coronary occlusionMicrosphere blood flowMyocardial blood flowOpen-chest canine modelVivo SPECT imagesSPECT imagesVivo planarCentral ischemic regionCoronary occlusionDemand ischemiaBMS181321Technetium-99mIntravenous injectionLiver ratioMyocardial imagingCanine modelPositive imagingHepatic clearanceLiver activityArterial sampling
1989
Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging.
Wackers F, Berman D, Maddahi J, Watson D, Beller G, Strauss H, Boucher C, Picard M, Holman B, Fridrich R. Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. Journal Of Nuclear Medicine 1989, 30: 301-11. PMID: 2525610.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseMulticenter phase II clinical trialSignificant coronary artery diseasePhase II clinical trialMulticenter phase IStress imagesMyocardial perfusion imagingNew myocardial imaging agentHuman biodistributionClinical efficacyClinical trialsMyocardial analysisStress imagingMyocardial imaging agentMyocardial uptakeMyocardial segmentsNormal volunteersThallium-201Myocardial imagingPerfusion imagingPatientsPhase IExact concordanceMyocardial images
1988
Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging.
Kayden D, Mattera J, Zaret B, Wackers F. Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging. Journal Of Nuclear Medicine 1988, 29: 1865-7. PMID: 2972815.Peer-Reviewed Original ResearchConceptsThrombolytic therapyMyocardial infarctionRecombinant tissue plasminogen activatorAcute anteroseptal myocardial infarctionSuccess of reperfusionSalvage of myocardiumAcute myocardial infarctionAnteroseptal myocardial infarctionMyocardial perfusion defectsMyocardial perfusion imagingTissue plasminogen activatorEmergency roomRepeat injectionsPerfusion defectsIntravenous injectionMyocardial imagingPerfusion imagingMyocardial redistributionInfarctionNoninvasive meansPlasminogen activatorReperfusionImaging agentTherapyTechnetium
1985
Radionuclide Techniques for Diagnosing and Sizing of Myocardial Infarction
Wackers F. Radionuclide Techniques for Diagnosing and Sizing of Myocardial Infarction. 1985, 179-187. DOI: 10.1007/978-1-4613-3828-4_20.Peer-Reviewed Original ResearchRadionuclide techniquesAcute ischemic heart diseaseEvaluation of patientsIschemic heart diseaseAssessment of rightIll patientsVentricular functionMyocardial infarctionHeart diseaseLittle discomfortMyocardial imagingNew radiotracersPatient's bedsidePatientsNon-invasive natureNuclear cardiologyBedsideInfarctionDiseaseCardiology
1980
Myocardial Imaging with Thallium-201 and Technetium-99m-Pyrophosphate in the Coronary Care Unit: Conclusion
Wackers F, Willerson J. Myocardial Imaging with Thallium-201 and Technetium-99m-Pyrophosphate in the Coronary Care Unit: Conclusion. Developments In Cardiovascular Medicine 1980, 9: 241-244. DOI: 10.1007/978-94-009-8904-7_14.Peer-Reviewed Original ResearchAcute myocardial infarctionMyocardial infarctionMyocar-dial infarctionAcute chest painCoronary care unitChest painCare unitClinical recognitionTechnetium-99mPatient historyThallium-201Myocardial imagingSerum enzymesInfarctionPatientsImaging techniquesSuccessful visualizationFirst reportMultiple reasonsPainMyocardiumDiagnosisThallium-201 Myocardial Imaging in Acute Myocardial Infarction
Wackers F, Lie K, Busemann Sokole E, Wellens H, Samson G, van der Schoot J. Thallium-201 Myocardial Imaging in Acute Myocardial Infarction. Developments In Cardiovascular Medicine 1980, 9: 117-160. DOI: 10.1007/978-94-009-8904-7_6.Peer-Reviewed Original ResearchAcute myocardial infarctionMyocardial infarctionThallium-201 myocardial imagingThallium-201 scintigraphyCoronary care unitMyocardial perfusion abnormalitiesLeft lateral viewIll patientsCare unitPerfusion abnormalitiesMobile gamma cameraMyocardial imagingPatientsInfarctionAnterior viewBed sideOblique viewScintigraphyEarly phaseGamma cameraSensitive techniqueAbnormalitiesThallium-201 Myocardial Imaging
Wackers F. Thallium-201 Myocardial Imaging. Developments In Cardiovascular Medicine 1980, 9: 71-104. DOI: 10.1007/978-94-009-8904-7_4.Peer-Reviewed Original ResearchThallium-201 Myocardial Imaging as a Selection Method for the Coronary Care Unit
Wackers F, Lie K, Busemann Sokole E, Samson G, van der Schoot J. Thallium-201 Myocardial Imaging as a Selection Method for the Coronary Care Unit. Developments In Cardiovascular Medicine 1980, 9: 223-235. DOI: 10.1007/978-94-009-8904-7_12.Peer-Reviewed Original ResearchCoronary care unitAcute myocardial infarctionCare unitMyocardial infarctionThallium-201 myocardial imagingCoronary artery insufficiencyInitial electrocardiogramNondiagnostic electrocardiogramQuestionable historyPatient admissionsMyocardial imagingPatientsInitial evaluationInfarctionSubstantial groupDiagnosisComplaintsElectrocardiogramSignificant numberIschemiaAdmissionHospitalEtiologyInsufficiencyFurther observations
1978
Prevalence of right ventricular involvement in inferior wall infarction assessed with myocardial imaging with thallium-201 and technetium-99m pyrophosphate
Wackers F, Lie K, Sokole E, Res J, Van Der Schoot J, Durrer D. Prevalence of right ventricular involvement in inferior wall infarction assessed with myocardial imaging with thallium-201 and technetium-99m pyrophosphate. The American Journal Of Cardiology 1978, 42: 358-362. PMID: 210648, DOI: 10.1016/0002-9149(78)90928-1.Peer-Reviewed Original ResearchConceptsRight ventricular involvementAcute inferior wall infarctionInferior wall infarctionVentricular involvementThallium-201Myocardial imagingSevere right ventricular failurePump failurePositive pyrophosphate scansSevere pump failureRight ventricular failureSubgroup of patientsThallium-201 defectsPyrophosphate scanCardiogenic shockVentricular dysfunctionVentricular failureConsecutive patientsConsecutive seriesClassic signsPatientsClinical relevanceInfarctionNonivasive methodVolume loading
1975
Noninvasive visualization of acute myocardial infarction in man with thallium-201.
Wackers F, Schoot J, Sokole E, Samson G, Niftrik G, Lie K, Durrer D, Wellens H. Noninvasive visualization of acute myocardial infarction in man with thallium-201. Heart 1975, 37: 741. PMID: 1156481, PMCID: PMC482866, DOI: 10.1136/hrt.37.7.741.Peer-Reviewed Original Research