2017
Physical inactivity and cardiac events: An analysis of the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study
McCarthy M, Wackers F, Davey J, Chyun D. Physical inactivity and cardiac events: An analysis of the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study. Journal Of Clinical & Translational Endocrinology 2017, 9: 8-14. PMID: 29067262, PMCID: PMC5651289, DOI: 10.1016/j.jcte.2017.05.005.Peer-Reviewed Original ResearchCoronary artery diseaseHigher pulse pressurePremature coronary artery diseaseCAD eventsPhysical inactivityPulse pressureDetection of ischemiaPeripheral numbnessDiabetes durationIndependent predictorsHip ratioFamily historyOlder adultsAsymptomatic Diabetics (DIAD) studyCAD event ratesProportional hazard modelingImportant risk factorType 2 diabetesCause of deathAsymptomatic diabeticsInsulin useBaseline characteristicsCardiac eventsArtery diseaseHemoglobin A1c
2010
Hyperglycemia on admission predicts larger infarct size in patients undergoing percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
Cruz-Gonzalez I, Chia S, Raffel O, Sanchez-Ledesma M, Senatore F, Wackers F, Nathan D, Jang I. Hyperglycemia on admission predicts larger infarct size in patients undergoing percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Diabetes Research And Clinical Practice 2010, 88: 97-102. PMID: 20083319, DOI: 10.1016/j.diabres.2010.01.001.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionAcute ST-segment elevation myocardial infarctionPrimary PCILarger infarct sizeElevation myocardial infarctionPercutaneous coronary interventionInfarct sizeCoronary interventionMyocardial infarctionDay 5Final TIMI 3 flowTIMI 3 flowMultivariate linear regression analysisSingle photon emissionAdmission correlateSTEMI patientsBaseline characteristicsDiabetic statusHyperglycemia groupIndependent predictorsHyperglycemiaPatientsLinear regression analysisAdmission
2004
Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study)
Papaioannou GI, Seip RL, Grey NJ, Katten D, Taylor A, Inzucchi SE, Young LH, Chyun DA, Davey JA, Wackers FJ, Iskandrian AE, Ratner RE, Robinson EC, Carolan S, Engel S, Heller GV. Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study). The American Journal Of Cardiology 2004, 94: 294-299. PMID: 15276091, DOI: 10.1016/j.amjcard.2004.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAlbuminuriaBrachial ArteryCoronary Artery DiseaseC-Reactive ProteinDiabetes Mellitus, Type 2Diabetic AngiopathiesEndothelium, VascularFemaleHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisProspective StudiesReference ValuesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSex FactorsUltrasonography, DopplerVasoconstrictionVasodilationConceptsEndothelium-independent vasodilationEndothelium-dependent vasodilationBrachial artery reactivityType 2 diabetes mellitusHormone replacement therapyDiabetes mellitusC-reactive proteinSystemic inflammationAsymptomatic patientsEndothelial dysfunctionIndependent predictorsReplacement therapyNovel atherosclerotic risk factorAsymptomatic Diabetics (DIAD) studyAtherosclerotic risk factorsPresence of microalbuminuriaFuture cardiovascular eventsSimilar baseline characteristicsDetection of ischemiaCardiovascular eventsBaseline characteristicsBrachial arteryVascular dysfunctionEntire cohortRisk factors
1996
Distortion of the Terminal Portion of the QRS on the Admission Electrocardiogram in Acute Myocardial Infarction and Correlation With Infarct Size and Long-Term Prognosis (Thrombolysis In Myocardial Infarction 4 Trial)**This study was supported in part by a grant from SmithKline Beecham, Philadelphia, Pennsylvania.
Birnbaum Y, Kloner R, Sclarovsky S, Cannon C, McCabe C, Davis V, Zaret B, Wackers F, Braunwald E. Distortion of the Terminal Portion of the QRS on the Admission Electrocardiogram in Acute Myocardial Infarction and Correlation With Infarct Size and Long-Term Prognosis (Thrombolysis In Myocardial Infarction 4 Trial)**This study was supported in part by a grant from SmithKline Beecham, Philadelphia, Pennsylvania. The American Journal Of Cardiology 1996, 78: 396-403. PMID: 8752182, DOI: 10.1016/s0002-9149(96)00326-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAngina PectorisCardiac Output, LowCoronary AngiographyCreatine KinaseDouble-Blind MethodElectrocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionPatient AdmissionPrognosisRecurrenceRetrospective StudiesStroke VolumeSurvival RateTechnetium Tc 99m SestamibiThrombolytic TherapyTreatment OutcomeVentricular Function, LeftConceptsAcute myocardial infarctionLong-term prognosisAnterior acute myocardial infarctionCreatine kinase releaseInfarct sizeMyocardial infarctionMyocardial infarction (TIMI) 4 trialAnterior AMI patientsOne-year mortalityCoronary angiographic findingsLarger infarct sizeVentricular ejection fractionAdmission electrocardiogramHospital mortalityPrevious anginaSestamibi defectsAngiographic findingsBaseline characteristicsEjection fractionHeart failureAMI patientsClinical outcomesQRS distortionPatientsEnd point