2021
Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study
Guerrera F, Falcoz PE, Moser B, van Raemdonck D, Bille’ A, Toker A, Spaggiari L, Ampollini L, Filippini C, Thomas PA, Verdonck B, Mendogni P, Aigner C, Voltolini L, Novoa N, Patella M, Mantovani S, Bravio IG, Zisis C, Guirao A, Londero F, Congregado M, Rocco G, Du Pont B, Martucci N, Esch M, Brunelli A, Detterbeck FC, Venuta F, Weder W, Ruffini E, Centers T, Klepetko W, Olland A, Du Pont B, Nonaka D, Ozkan B, Iacono G, Braggio C, Filosso P, Brioude G, van Schil P, Nosotti M, Valdivia D, Bongiolatti S, Inci I, Dimitra R, Sànchez D, Grossi W, Moreno-Merino S, Teschner M. Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study. European Journal Of Cardio-Thoracic Surgery 2021, 60: 881-887. PMID: 34023891, PMCID: PMC10060729, DOI: 10.1093/ejcts/ezab224.Peer-Reviewed Original ResearchConceptsEarly-stage thymomaMyasthenia gravisTT groupST groupPropensity score-adjusted comparisonsNon-MG patientsPathological stage IPostoperative morbidity rateEuropean SocietyRate of complicationsCompleteness of resectionOverall survival rateLong-term outcomesProcedure of choiceMost relevant articlesOncological standpointCurative intentPostoperative complicationsPostoperative lengthTotal thymectomyOverall recurrenceThymic tumorsMorbidity rateSurgical approachThymus glandInvasive thymoma – Which patients benefit from post-operative radiotherapy?
Muslim Z, Baig MZ, Weber JF, Detterbeck FC, Connery CP, Spera JA, Bhora FY. Invasive thymoma – Which patients benefit from post-operative radiotherapy? Asian Cardiovascular And Thoracic Annals 2021, 29: 935-942. PMID: 33975467, DOI: 10.1177/02184923211017094.Peer-Reviewed Original ResearchConceptsPost-operative radiotherapyWorld Health Organization histologyMasaoka-Koga stageStage III thymomaPropensity-matched cohortStage III diseaseClinical pathological factorsEnd Results (SEER) databasePositive prognostic indicatorUnderwent surgerySurgical treatmentThymoma patientsAdvanced thymomaB3 tumorsPrognostic implicationsResults databaseTumor sizeInvasive thymomaPrognostic indicatorSurvival differencesPatientsRadiotherapyThymomaSurgeryTumors
2019
A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases
Zhao J, Bhatnagar V, Ding L, Atay SM, David EA, McFadden PM, Stamnes S, Lechtholz-Zey E, Wightman SC, Detterbeck FC, Kim AW. A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 306-314.e14. PMID: 31982129, DOI: 10.1016/j.jtcvs.2019.11.052.Peer-Reviewed Original ResearchA Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study
Liu H, Gu Z, Qiu B, Detterbeck FC, Roden AC, Ruffini E, Okumura M, Girard N, Xiang Y, Liu Y, Du Z, Hao Y, Fu J, Zhang P, Pang L, Chen K, Wang Y, Yu Z, Mao T, Fang W, Group A. A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study. Journal Of Thoracic Oncology 2019, 15: 448-456. PMID: 31726106, DOI: 10.1016/j.jtho.2019.10.018.Peer-Reviewed Original ResearchConceptsHigh-risk patientsAdjuvant therapyPostoperative yearThymic carcinomaComplete resectionPostoperative managementNeuroendocrine tumorsBootstrap-corrected C-indexChinese AlliancePostoperative adjuvant therapyIndependent predictive factorsLow-risk patientsMultivariate Cox regressionOverall survival rateAppropriate postoperative managementThymic epithelial tumorsHigh-risk groupLow-risk groupIIIA tumorsLocoregional recurrenceDisease recurrenceB3 thymomaHistologic typeNomogram modelT stageReport from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours
Ruffini E, Guerrera F, Brunelli A, Passani S, Pellicano D, Thomas P, Van Raemdonck D, Rocco G, Venuta F, Weder W, Detterbeck F, Falcoz PE. Report from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours. European Journal Of Cardio-Thoracic Surgery 2019, 55: 601-609. PMID: 30649256, DOI: 10.1093/ejcts/ezy448.Peer-Reviewed Original ResearchConceptsNeuroendocrine thymic tumoursThymic tumorsAdjuvant treatmentThymic carcinomaStage IStage IIIB tumorsEuropean SocietyStage IV tumorsOverall recurrence rateInvasive surgical approachNew International AssociationCollaborative global effortIIIB tumorsProspective databaseStage IIIAMetastasis classificationRecurrence rateGroup tumorsRare tumorSurgical approachRetrospective databaseInvasive techniquesStage IIIPatientsTumors
2016
Thymic Carcinoma Management Patterns among International Thymic Malignancy Interest Group (ITMIG) Physicians with Consensus from the Thymic Carcinoma Working Group
Shepherd A, Riely G, Detterbeck F, Simone CB, Ahmad U, Huang J, Korst R, Rajan A, Rimner A. Thymic Carcinoma Management Patterns among International Thymic Malignancy Interest Group (ITMIG) Physicians with Consensus from the Thymic Carcinoma Working Group. Journal Of Thoracic Oncology 2016, 12: 745-751. PMID: 27876674, PMCID: PMC5545114, DOI: 10.1016/j.jtho.2016.11.2219.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupThymic carcinomaAreas of controversyResectable diseaseMultimodality therapyClinical practiceFirst-line chemotherapy regimenDefinitive surgical resectionRare epithelial malignancyManagement of patientsCurrent clinical practiceFit patientsAdjuvant therapyChemotherapy regimenSurgical resectionThymic malignanciesHistologic confirmationTreatment courseTreatment strategiesEpithelial malignanciesGreat vesselsMultidisciplinary discussionGroup physiciansWorking GroupCarcinomaPostoperative Radiation Therapy Is Associated with Longer Overall Survival in Completely Resected Stage II and III Thymoma—An Analysis of the International Thymic Malignancies Interest Group Retrospective Database
Rimner A, Yao X, Huang J, Antonicelli A, Ahmad U, Korst RJ, Detterbeck F, Gomez DR. Postoperative Radiation Therapy Is Associated with Longer Overall Survival in Completely Resected Stage II and III Thymoma—An Analysis of the International Thymic Malignancies Interest Group Retrospective Database. Journal Of Thoracic Oncology 2016, 11: 1785-1792. PMID: 27346413, PMCID: PMC5257334, DOI: 10.1016/j.jtho.2016.06.011.Peer-Reviewed Original ResearchConceptsPostoperative radiation therapyStage IIOS benefitRadiation therapyUse of PORTMasaoka-Koga stage IIInternational Thymic Malignancy Interest GroupStage II thymomaOverall survival benefitPrimary end pointMultivariate Cox modelLonger overall survivalLog-rank testIndividual patient dataImproved OSParaneoplastic syndromeOverall survivalSurvival benefitOS ratesHistologic subtypePatient populationRetrospective databaseUnivariate analysisCox modelThymomaComparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group†
Filosso PL, Yao X, Ruffini E, Ahmad U, Antonicelli A, Huang J, Guerrera F, Venuta F, van Raemdonck D, Travis W, Lucchi M, Rimner A, Thomas P, Weder W, Rocco G, Detterbeck F, Korst R. Comparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group†. European Journal Of Cardio-Thoracic Surgery 2016, 50: 766-771. PMID: 27032473, PMCID: PMC6279171, DOI: 10.1093/ejcts/ezw107.Peer-Reviewed Original ResearchConceptsNeuroendocrine thymic tumoursRecurrence-free survivalThymic carcinomaOverall survivalSurvival rateThymic tumorsThoracic surgeonsFive-year recurrence-free survivalWorld Health Organization histological classificationRetrospective multicentre cohort studyInternational Thymic Malignancy Interest GroupMedian overall survivalMulticentre cohort studyEuropean SocietyKaplan-Meier methodThymic epithelial tumorsLarge clinical seriesLog-rank testComparison of outcomesGroup of tumorsR0 resectionCohort studyPrognostic factorsNET patientsTC patients
2015
The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes
Marx A, Chan JK, Coindre JM, Detterbeck F, Girard N, Harris NL, Jaffe ES, Kurrer MO, Marom EM, Moreira AL, Mukai K, Orazi A, Ströbel P. The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. Journal Of Thoracic Oncology 2015, 10: 1383-1395. PMID: 26295375, PMCID: PMC4581965, DOI: 10.1097/jto.0000000000000654.Peer-Reviewed Original ResearchConceptsWorld Health Organization classificationThymic epithelial tumorsOrganization classificationEpithelial tumorsThymic squamous cell carcinomaPositron emission tomography/Squamous cell carcinomaGerm cell tumorsNew tumor entityEmission tomography/Soft tissue tumorsClassification of tumorsDendritic cellsMediastinal lymphomaThymic tumorsCell carcinomaCell tumorsThoracic surgeryTomography/Therapeutic decisionsThymus sectionsMyeloid neoplasmsTumor entitiesDiagnostic criteriaClinical relevanceMultimodality therapy for locally advanced thymomas: A propensity score–matched cohort study from the European Society of Thoracic Surgeons Database
Leuzzi G, Rocco G, Ruffini E, Sperduti I, Detterbeck F, Weder W, Venuta F, Van Raemdonck D, Thomas P, Facciolo F, Group E. Multimodality therapy for locally advanced thymomas: A propensity score–matched cohort study from the European Society of Thoracic Surgeons Database. Journal Of Thoracic And Cardiovascular Surgery 2015, 151: 47-57.e1. PMID: 26403869, DOI: 10.1016/j.jtcvs.2015.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAsiaChemotherapy, AdjuvantChi-Square DistributionChildDatabases, FactualDisease ProgressionDisease-Free SurvivalEuropeFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingNorth AmericaPropensity ScoreProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentRisk FactorsSocieties, MedicalThymectomyThymomaThymus NeoplasmsTime FactorsTreatment OutcomeTumor BurdenYoung AdultConceptsRelapse-free survivalAdvanced thymomaMultimodality therapyOverall survivalT classificationPropensity score-matched cohort studyMultivariate Cox proportional hazards modelPropensity score-matched analysisCox proportional hazards modelPathologic T classificationStage III thymomaThoracic Surgeons databaseSignificant survival advantageSpecific pathologic featuresStrong predictive factorProportional hazards modelInduction therapyAdjuvant therapyPT3 tumorsCohort studyIndependent predictorsPrognostic impactMultivariable analysisPathologic featuresPredictive factorsEditorial Commentary: Be Careful about Drawing Big Conclusions from Big Data
Detterbeck FC. Editorial Commentary: Be Careful about Drawing Big Conclusions from Big Data. Seminars In Thoracic And Cardiovascular Surgery 2015, 27: 4-5. PMID: 26074101, DOI: 10.1053/j.semtcvs.2015.02.008.Peer-Reviewed Original ResearchThe Impact of Thymoma Histotype on Prognosis in a Worldwide Database
Weis CA, Yao X, Deng Y, Detterbeck FC, Marino M, Nicholson AG, Huang J, Ströbel P, Antonicelli A, Marx A, Database C. The Impact of Thymoma Histotype on Prognosis in a Worldwide Database. Journal Of Thoracic Oncology 2015, 10: 367-372. PMID: 25616178, PMCID: PMC4318643, DOI: 10.1097/jto.0000000000000393.Peer-Reviewed Original Research
2014
Thymic carcinoma outcomes and prognosis: Results of an international analysis
Ahmad U, Yao X, Detterbeck F, Huang J, Antonicelli A, Filosso PL, Ruffini E, Travis W, Jones DR, Zhan Y, Lucchi M, Rimner A. Thymic carcinoma outcomes and prognosis: Results of an international analysis. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 95-101.e2. PMID: 25524678, DOI: 10.1016/j.jtcvs.2014.09.124.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingPractice Patterns, Physicians'Proportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk FactorsSex FactorsThymectomyThymomaThyroid NeoplasmsTime FactorsTreatment OutcomeConceptsRecurrence-free survivalEarly Masaoka stageR0 resectionOverall survivalRadiation therapyMasaoka stageThymic carcinomaMale genderLonger recurrence-free survivalMedian overall survivalStage IV diseaseAdjuvant radiation therapyMasaoka stage IPreoperative radiation therapyPrimary outcome measureSquamous cell carcinomaPredominant histologic subtypeAdjuvant chemotherapyImproved OSInduction chemotherapyProlonged OSCumulative incidenceHistologic subtypeMultivariable analysisTreatment patternsITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting
Marx A, Ströbel P, Badve SS, Chalabreysse L, Chan JK, Chen G, de Leval L, Detterbeck F, Girard N, Huang J, Kurrer MO, Lauriola L, Marino M, Matsuno Y, Molina TJ, Mukai K, Nicholson AG, Nonaka D, Rieker R, Rosai J, Ruffini E, Travis WD. ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting. Journal Of Thoracic Oncology 2014, 9: 596-611. PMID: 24722150, DOI: 10.1097/jto.0000000000000154.Peer-Reviewed Original ResearchConceptsThymic carcinomaThymic epithelial tumorsB3 thymomaEpithelial tumorsInternational Thymic Malignancy Interest GroupWorld Health Organization classificationPoor interobserver reproducibilityHistological patternOrganization classificationConsensus statementHistological classificationHistological criteriaThymoma subtypesThymomaAtypical typeGrading systemInterobserver reproducibilityTumorsCarcinomaReproducibility studyRefined criteriaMorphological overlapSubtypesVariable proportionsStandard Terms, Defnitions, and Policies for Minimally Invasive Resection of Thymoma
Toker A, Sonett J, Zielinski M, Rea F, Tomulescu V, Detterbeck FC. Standard Terms, Defnitions, and Policies for Minimally Invasive Resection of Thymoma. Chinese Journal Of Lung Cancer 2014, 17: 90-94. PMID: 24581158, PMCID: PMC6131241, DOI: 10.3779/j.issn.1009-3419.2014.02.05.Peer-Reviewed Original ResearchWhich Way is Up? Policies and Procedures for Surgeons and Pathologists Regarding Resection Specimens of Thymic Malignancy
Detterbeck FC, Moran C, Huang J, Suster S, Walsh G, Kaiser L, Wick M. Which Way is Up? Policies and Procedures for Surgeons and Pathologists Regarding Resection Specimens of Thymic Malignancy. Chinese Journal Of Lung Cancer 2014, 17: 95-103. PMID: 24581159, PMCID: PMC6131236, DOI: 10.3779/j.issn.1009-3419.2014.02.06.Peer-Reviewed Original ResearchThe Masaoka-Koga Stage Classifcation for Thymic Malignancies Clarifcation and Defnition of Terms
Detterbeck FC, Nicholson AG, Kondo K, Van Schil P, Moran C. The Masaoka-Koga Stage Classifcation for Thymic Malignancies Clarifcation and Defnition of Terms. Chinese Journal Of Lung Cancer 2014, 17: 75-81. PMID: 24581156, PMCID: PMC6131234, DOI: 10.3779/j.issn.1009-3419.2014.02.03.Peer-Reviewed Original ResearchTumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database
Ruffini E, Detterbeck F, Van Raemdonck D, Rocco G, Thomas P, Weder W, Brunelli A, Evangelista A, Venuta F, Khaled A, Arame A, Refai M, Casadio C, Carbognani P, Cerfolio R, Donati G, Foroulis C, Gebitekin C, de Antonio D, Kernstine K, Keshavjee S, Moser B, Lequaglie C, Liberman M, Lim E, Nicholson A, Lang-Lazdunski L, Mancuso M, Altorki N, Nosotti M, Novoa N, Brioude G, Oliaro A, Filosso P, Saita S, Scarci M, Schützner J, Terzi A, Toker A, Van Veer H, Anile M, Rendina E, Voltolini L, Zurek W. Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database. European Journal Of Cardio-Thoracic Surgery 2014, 46: 361-368. PMID: 24482389, PMCID: PMC4155438, DOI: 10.1093/ejcts/ezt649.Peer-Reviewed Original ResearchConceptsOverall survivalAdjuvant therapyIncomplete resectionComplete resectionThymic tumorsTumor sizeWorld Health Organization histologyTen-year OSDisease-free survivalEuropean SocietyType of resectionClinical pathological characteristicsRisk of recurrenceShorter overall survivalThoracic Surgeons databaseR0 resectionCohort studyCumulative incidenceSecondary outcomesImproved survivalPrimary outcomePrognostic factorsIncident casesPrognostic predictorSurgeons database
2013
Pediatric thymomas: report of two cases and comprehensive review of the literature
Fonseca AL, Ozgediz DE, Christison-Lagay ER, Detterbeck FC, Caty MG. Pediatric thymomas: report of two cases and comprehensive review of the literature. Pediatric Surgery International 2013, 30: 275-286. PMID: 24322668, DOI: 10.1007/s00383-013-3438-x.Peer-Reviewed Original ResearchConceptsStage diseaseSurgical excisionRare pediatric malignancyMasaoka stage IEarly-stage diseaseSlight male predominanceTreatment of thymomaLate-stage diseaseMulti-institutional studyPediatric thymomaAdjuvant therapyClinical courseMyasthenia gravisPrognostic factorsMale predominanceIndolent behaviorPediatric malignanciesRare tumorCase reportReference listsStage IIIThymomaStage IStage IVPubMed databaseThymoma: current diagnosis and treatment.
Detterbeck FC, Zeeshan A. Thymoma: current diagnosis and treatment. Chinese Medical Journal 2013, 126: 2186-91. PMID: 23769581, DOI: 10.3760/cma.j.issn.0366-6999.20130177.Peer-Reviewed Original ResearchConceptsComplete resectionInternational Thymic Malignancy Interest GroupMasaoka-Koga classificationMainstay of treatmentMajor prognostic factorAnterior mediastinal tumorTreatment of thymomaEarly-stage thymomaRare malignant tumorCore needle biopsyStandard diagnostic modalityFine-needle aspirationFormal systematic reviewMajor blood vesselsIVA tumorsPreoperative chemotherapyPrimary surgeryPostoperative radiationPrognostic factorsSurgical resectionThymic malignanciesMediastinal tumorMyasthenia gravisThymoma resectionIntravenous contrast