2021
Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study
Guerrera F, Falcoz PE, Moser B, van Raemdonck D, Bille’ A, Toker A, Spaggiari L, Ampollini L, Filippini C, Thomas PA, Verdonck B, Mendogni P, Aigner C, Voltolini L, Novoa N, Patella M, Mantovani S, Bravio IG, Zisis C, Guirao A, Londero F, Congregado M, Rocco G, Du Pont B, Martucci N, Esch M, Brunelli A, Detterbeck FC, Venuta F, Weder W, Ruffini E, Centers T, Klepetko W, Olland A, Du Pont B, Nonaka D, Ozkan B, Iacono G, Braggio C, Filosso P, Brioude G, van Schil P, Nosotti M, Valdivia D, Bongiolatti S, Inci I, Dimitra R, Sànchez D, Grossi W, Moreno-Merino S, Teschner M. Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study. European Journal Of Cardio-Thoracic Surgery 2021, 60: 881-887. PMID: 34023891, PMCID: PMC10060729, DOI: 10.1093/ejcts/ezab224.Peer-Reviewed Original ResearchConceptsEarly-stage thymomaMyasthenia gravisTT groupST groupPropensity score-adjusted comparisonsNon-MG patientsPathological stage IPostoperative morbidity rateEuropean SocietyRate of complicationsCompleteness of resectionOverall survival rateLong-term outcomesProcedure of choiceMost relevant articlesOncological standpointCurative intentPostoperative complicationsPostoperative lengthTotal thymectomyOverall recurrenceThymic tumorsMorbidity rateSurgical approachThymus gland
2019
The International Association for the Study of Lung Cancer Thymic Tumors Staging Project: The Impact of the Eighth Edition of the Union for International Cancer Control and American Joint Committee on Cancer TNM Stage Classification of Thymic Tumors
Ruffini E, Fang W, Guerrera F, Huang J, Okumura M, Kim DK, Girard N, Billè A, Boubia S, Cangir AK, Detterbeck F, Falkson C, Filosso PL, Giaccone G, Kondo K, Infante M, Lucchi M, Marino M, Marom EM, Nicholson AG, Rimner A, Rami-Porta R, Asamura H, Committee S, Subcommittee S, Subcommittees S, Boards M. The International Association for the Study of Lung Cancer Thymic Tumors Staging Project: The Impact of the Eighth Edition of the Union for International Cancer Control and American Joint Committee on Cancer TNM Stage Classification of Thymic Tumors. Journal Of Thoracic Oncology 2019, 15: 436-447. PMID: 31783179, DOI: 10.1016/j.jtho.2019.11.013.Peer-Reviewed Original ResearchConceptsTNM stage classificationAmerican Joint CommitteeThymic tumorsStaging systemT categoryN categoryJoint CommitteeInternational Cancer Control/American Joint CommitteeMasaoka-Koga staging systemMediastinal pleural involvementLymph node dissectionWeb-based cross-sectional surveyLung cancer stagingInternational Cancer ControlCross-sectional surveyNode dissectionPleural involvementThymic carcinomaTNM classificationTNM systemCancer controlCancer stagingThoracic communityWeb-based questionnaireStage classificationReport from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours
Ruffini E, Guerrera F, Brunelli A, Passani S, Pellicano D, Thomas P, Van Raemdonck D, Rocco G, Venuta F, Weder W, Detterbeck F, Falcoz PE. Report from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours. European Journal Of Cardio-Thoracic Surgery 2019, 55: 601-609. PMID: 30649256, DOI: 10.1093/ejcts/ezy448.Peer-Reviewed Original ResearchConceptsNeuroendocrine thymic tumoursThymic tumorsAdjuvant treatmentThymic carcinomaStage IStage IIIB tumorsEuropean SocietyStage IV tumorsOverall recurrence rateInvasive surgical approachNew International AssociationCollaborative global effortIIIB tumorsProspective databaseStage IIIAMetastasis classificationRecurrence rateGroup tumorsRare tumorSurgical approachRetrospective databaseInvasive techniquesStage IIIPatientsTumors
2017
Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database
Korst RJ, Fernando S, Catlin AC, Rutledge JR, Girard N, Huang J, Detterbeck F, Database C. Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database. The Annals Of Thoracic Surgery 2017, 104: 1815-1820. PMID: 29033016, PMCID: PMC5785101, DOI: 10.1016/j.athoracsur.2017.06.053.Peer-Reviewed Original ResearchConceptsPositron emission tomographyInternational Thymic Malignancy Interest GroupHistologic typeThymic malignanciesPretreatment workupPathologic stageEmission tomographyProspective databaseThymic tumorsTumor stageMaximum standardized uptake valueProspective research databaseHistologic tumor typeThymic epithelial tumorsStandardized uptake valueCharacteristic curveAnalysis of receiverClinicopathologic featuresRare tumorEpithelial tumorsLarge cohortResearch DatabaseUptake valueTumor typesPatientsComparison of surgical approach and extent of resection for Masaoka-Koga Stage I and II thymic tumours in Europe, North America and Asia: an International Thymic Malignancy Interest Group retrospective database analysis†
Fang W, Yao X, Antonicelli A, Gu Z, Detterbeck F, Vallières E, Aye RW, Farivar AS, Huang J, Shang Y, Louie BE. Comparison of surgical approach and extent of resection for Masaoka-Koga Stage I and II thymic tumours in Europe, North America and Asia: an International Thymic Malignancy Interest Group retrospective database analysis†. European Journal Of Cardio-Thoracic Surgery 2017, 52: 26-32. PMID: 28329118, PMCID: PMC6279116, DOI: 10.1093/ejcts/ezx042.Peer-Reviewed Original ResearchConceptsExtent of resectionThymic tumorsStage IAsian patientsSurgical approachOnly independent predictive factorMasaoka-Koga stage IMore stage IOutcomes of patientsPathological stage IIndependent predictive factorsIndependent risk factorOverall survival rateCumulative recurrence rateSmaller tumor sizeRetrospective database analysisNorth American patientsPartial thymectomyAdjuvant therapyParaneoplastic syndromeThymic carcinomaOverall survivalPerformance statusComplete resectionMyasthenia gravis
2016
Dataset for reporting of thymic epithelial tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR)
Nicholson AG, Detterbeck F, Marx A, Roden AC, Marchevsky AM, Mukai K, Chen G, Marino M, Bakker M, Yang W, Judge M, Hirschowitz L. Dataset for reporting of thymic epithelial tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR). Histopathology 2016, 70: 522-538. PMID: 27735079, DOI: 10.1111/his.13099.Peer-Reviewed Original ResearchComparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group†
Filosso PL, Yao X, Ruffini E, Ahmad U, Antonicelli A, Huang J, Guerrera F, Venuta F, van Raemdonck D, Travis W, Lucchi M, Rimner A, Thomas P, Weder W, Rocco G, Detterbeck F, Korst R. Comparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group†. European Journal Of Cardio-Thoracic Surgery 2016, 50: 766-771. PMID: 27032473, PMCID: PMC6279171, DOI: 10.1093/ejcts/ezw107.Peer-Reviewed Original ResearchConceptsNeuroendocrine thymic tumoursRecurrence-free survivalThymic carcinomaOverall survivalSurvival rateThymic tumorsThoracic surgeonsFive-year recurrence-free survivalWorld Health Organization histological classificationRetrospective multicentre cohort studyInternational Thymic Malignancy Interest GroupMedian overall survivalMulticentre cohort studyEuropean SocietyKaplan-Meier methodThymic epithelial tumorsLarge clinical seriesLog-rank testComparison of outcomesGroup of tumorsR0 resectionCohort studyPrognostic factorsNET patientsTC patients
2015
The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes
Marx A, Chan JK, Coindre JM, Detterbeck F, Girard N, Harris NL, Jaffe ES, Kurrer MO, Marom EM, Moreira AL, Mukai K, Orazi A, Ströbel P. The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. Journal Of Thoracic Oncology 2015, 10: 1383-1395. PMID: 26295375, PMCID: PMC4581965, DOI: 10.1097/jto.0000000000000654.Peer-Reviewed Original ResearchConceptsWorld Health Organization classificationThymic epithelial tumorsOrganization classificationEpithelial tumorsThymic squamous cell carcinomaPositron emission tomography/Squamous cell carcinomaGerm cell tumorsNew tumor entityEmission tomography/Soft tissue tumorsClassification of tumorsDendritic cellsMediastinal lymphomaThymic tumorsCell carcinomaCell tumorsThoracic surgeryTomography/Therapeutic decisionsThymus sectionsMyeloid neoplasmsTumor entitiesDiagnostic criteriaClinical relevance
2014
Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database
Ruffini E, Detterbeck F, Van Raemdonck D, Rocco G, Thomas P, Weder W, Brunelli A, Evangelista A, Venuta F, Khaled A, Arame A, Refai M, Casadio C, Carbognani P, Cerfolio R, Donati G, Foroulis C, Gebitekin C, de Antonio D, Kernstine K, Keshavjee S, Moser B, Lequaglie C, Liberman M, Lim E, Nicholson A, Lang-Lazdunski L, Mancuso M, Altorki N, Nosotti M, Novoa N, Brioude G, Oliaro A, Filosso P, Saita S, Scarci M, Schützner J, Terzi A, Toker A, Van Veer H, Anile M, Rendina E, Voltolini L, Zurek W. Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database. European Journal Of Cardio-Thoracic Surgery 2014, 46: 361-368. PMID: 24482389, PMCID: PMC4155438, DOI: 10.1093/ejcts/ezt649.Peer-Reviewed Original ResearchConceptsOverall survivalAdjuvant therapyIncomplete resectionComplete resectionThymic tumorsTumor sizeWorld Health Organization histologyTen-year OSDisease-free survivalEuropean SocietyType of resectionClinical pathological characteristicsRisk of recurrenceShorter overall survivalThoracic Surgeons databaseR0 resectionCohort studyCumulative incidenceSecondary outcomesImproved survivalPrimary outcomePrognostic factorsIncident casesPrognostic predictorSurgeons database
2013
The international thymic malignancy interest group.
Detterbeck FC. The international thymic malignancy interest group. Journal Of The National Comprehensive Cancer Network 2013, 11: 589-93. PMID: 23667208, DOI: 10.6004/jnccn.2013.0074.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupNCCN Clinical Practice GuidelinesMore evidence-based guidelinesSeries of patientsClinical practice guidelinesEvidence-based guidelinesSignificant clinical valueThymic tumorsTreatment recommendationsPractice guidelinesClinical valueOrphan diseaseGuidelinesPatientsGroupTumorsDiseaseOncology
2011
Management of Thymic Tumors: A Survey of Current Practice among Members of the European Society of Thoracic Surgeons
Ruffini E, Van Raemdonck D, Detterbeck F, Rocco G, Thomas P, Venuta F, Group T. Management of Thymic Tumors: A Survey of Current Practice among Members of the European Society of Thoracic Surgeons. Journal Of Thoracic Oncology 2011, 6: 614-623. PMID: 21266921, DOI: 10.1097/jto.0b013e318207cd74.Peer-Reviewed Original ResearchConceptsThymic tumorsPreoperative assessmentTomography scanThoracic surgeonsPositron emission tomography scanWorld Health Organization classificationRole of surgeryStage IVA thymomaEuropean SocietyEmission tomography scanManagement of thymomasESTS membersReliable staging systemType C thymomasAreas of controversyIVA thymomaExtrapleural pneumonectomyExtended resectionRecurrent diseasePostoperative treatmentThymic malignanciesHistologic confirmationStaging systemOrganization classificationObservational study
2004
Thymic tumors
Detterbeck FC, Parsons AM. Thymic tumors. The Annals Of Thoracic Surgery 2004, 77: 1860-1869. PMID: 15111216, DOI: 10.1016/j.athoracsur.2003.10.001.Peer-Reviewed Original ResearchConceptsComplete resectionThymic tumorsMainstay of treatmentSurvival of patientsIVA thymomaPostoperative radiotherapyThymic carcinomaPreoperative chemotherapyIndolent coursePartial resectionStage IIIResectionThymomaPatientsAggressive behaviorTumorsLittle benefitSuch casesChemotherapyCarcinomaRadiotherapyMainstay