2017
Interobserver Variation among Pathologists and Refinement of Criteria in Distinguishing Separate Primary Tumors from Intrapulmonary Metastases in Lung
Nicholson AG, Torkko K, Viola P, Duhig E, Geisinger K, Borczuk AC, Hiroshima K, Tsao MS, Warth A, Lantuejoul S, Russell PA, Thunnissen E, Marchevsky A, Mino-Kenudson M, Beasley MB, Botling J, Dacic S, Yatabe Y, Noguchi M, Travis WD, Kerr K, Hirsch FR, Chirieac LR, Wistuba II, Moreira A, Chung JH, Chou TY, Bubendorf L, Chen G, Pelosi G, Poleri C, Detterbeck FC, Franklin WA. Interobserver Variation among Pathologists and Refinement of Criteria in Distinguishing Separate Primary Tumors from Intrapulmonary Metastases in Lung. Journal Of Thoracic Oncology 2017, 13: 205-217. PMID: 29127023, PMCID: PMC6276791, DOI: 10.1016/j.jtho.2017.10.019.Peer-Reviewed Original ResearchConceptsSecond primary lung cancerIntrapulmonary metastasesComprehensive histologic assessmentHistologic featuresHistologic patternLung pathologistsHistologic assessmentNuclear pleomorphismMitotic rateSeparate primary tumorsPrimary lung cancerMain histologic typesPredominant patternDistinctive histologic featuresMultiple tumor nodulesClear cell changeRefinement of criteriaLepidic growthHistologic subtypeHistologic typeVascular invasionPrimary tumorLung cancerTumor extentLung tumors
2016
The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Detterbeck FC, Franklin WA, Nicholson AG, Girard N, Arenberg DA, Travis WD, Mazzone PJ, Marom EM, Donington JS, Tanoue LT, Rusch VW, Asamura H, Rami-Porta R, Committee I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Boards A, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Workgroup M, Flieder D, Godoy M, Goo J, Goodman L, Jett J, de Leyn P, Marchevsky A, MacMahon H, Naidich D, Okada M, Perlman M, Powell C, van Schil P, Warth A. The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 651-665. PMID: 26944304, DOI: 10.1016/j.jtho.2016.01.025.Peer-Reviewed Original ResearchConceptsPrimary lung cancerSecond primary lung cancerSeparate primary lung cancersLung cancerIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectForthcoming Eighth EditionOutcomes of patientsMultidisciplinary tumor boardLung cancer stagingComprehensive histologic assessmentHistologic cancer typesAbsence of biomarkersMechanisms of metastasisPrognostic Factors CommitteeNodal involvementTNM classificationMetastatic fociPathologic criteriaPulmonary sitesSecond primaryHistologic assessmentTumor boardCancer stagingLung tumors
2012
Stereotactic Body Radiotherapy for Central Lung Tumors
Rowe BP, Boffa DJ, Wilson LD, Kim AW, Detterbeck FC, Decker RH. Stereotactic Body Radiotherapy for Central Lung Tumors. Journal Of Thoracic Oncology 2012, 7: 1394-1399. PMID: 22843088, DOI: 10.1097/jto.0b013e3182614bf3.Peer-Reviewed Original ResearchConceptsStereotactic body radiotherapyCentral lung tumorsBiological equivalent doseLocal recurrenceTracheobronchial treeLung tumorsBody radiotherapyCentral lesionsEquivalent doseGrade 3Baseline pulmonary function testsLarger maximum tumor diameterMedian biological equivalent doseChest wall painGrade 3 dyspneaYale Cancer CenterGrade 2 toxicityLocal control ratePrimary lung cancerPulmonary function testsHigh-grade toxicityMajority of patientsVolume of lungMaximum tumor diameterMaximum point dose
2004
Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation
Maygarden SJ, Detterbeck FC, Funkhouser WK. Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation. Modern Pathology 2004, 17: 1080-1086. PMID: 15133477, DOI: 10.1038/modpathol.3800154.Peer-Reviewed Original ResearchConceptsPositive marginsSite of tumorBronchial marginGross tumorFrozen sectionsWedge resectionCell carcinomaGross evaluationSalivary gland-type tumorsCentral lung tumorsPositive margin casesLung cancer resectionNonsmall cell carcinomaFrozen section evaluationSmall cell carcinomaFalse-negative casesTrue positive casesCancer resectionMucosal tumorsMargin positivityNegative marginsIntramucosal carcinomaTumor distanceUNC HospitalsLung tumors